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ONTOLOGY REPORT - ANNOTATIONS

Term:uniplex complex
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Accession:GO:1990246 term browser browse the term
Definition:A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
Synonyms:exact_synonym: mitochondrial uniporter complex;   mitochondrial uniporter holocomplex


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uniplex complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000066493 part_of IEA GO_REF:0000104
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 Ensembl chr19:39,079,782...39,080,340 JBrowse link
G Mcu mitochondrial calcium uniporter part_of ISO
IBA
IEA		 (PMID:24231807), (PMID:24560927), (PMID:31080062), (PMID:32315830), (PMID:32494073), (PMID:32762847), (PMID:32862359)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:24231807 PMID:24560927 PMID:31080062 PMID:32315830 PMID:32494073 More... GO_REF:0000033 GO_REF:0000107 NCBI chr20:27,960,520...28,123,103
Ensembl chr20:27,417,526...27,580,110 		JBrowse link
G Mcub mitochondrial calcium uniporter dominant negative subunit beta part_of ISO
IBA
IEA		 (PMID:24231807)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:24231807 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:221,153,525...221,223,814
Ensembl chr 2:218,479,301...218,549,593 		JBrowse link
G Micu1 mitochondrial calcium uptake 1 part_of ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:24231807), (PMID:24560927), (PMID:32494073), (PMID:32667285), (PMID:32762847), (PMID:32862359)		 UniProt
Ensembl
GO_Central
RGD		 PMID:24231807 PMID:24560927 PMID:32494073 PMID:32667285 PMID:32762847 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:28,211,774...28,357,928
Ensembl chr20:27,668,747...27,814,964 		JBrowse link
G Micu2 mitochondrial calcium uptake 2 part_of IEA
ISS
IBA
ISO		 GO_REF:0000107
GO_REF:0000024
GO_REF:0000033
(PMID:24231807), (PMID:24560927), (PMID:32494073), (PMID:32667285), (PMID:32762847), (PMID:32862359)		 Ensembl
UniProt
GO_Central
RGD		 PMID:24231807 PMID:24560927 PMID:32494073 PMID:32667285 PMID:32762847 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr15:36,180,413...36,262,429
Ensembl chr15:32,064,875...32,147,094 		JBrowse link
G Micu3 mitochondrial calcium uptake family, member 3 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:58,624,702...58,714,302
Ensembl chr16:51,925,225...52,010,613 		JBrowse link
G Smdt1 single-pass membrane protein with aspartate-rich tail 1 part_of ISO
IBA
IEA		 (PMID:24231807), (PMID:27642048), (PMID:31080062), (PMID:32315830), (PMID:32494073), (PMID:32762847), (PMID:32862359)
GO_REF:0000033
GO_REF:0000104
GO_REF:0000002		 RGD
GO_Central
UniProt
InterPro		 PMID:24231807 PMID:27642048 PMID:31080062 PMID:32315830 PMID:32494073 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 7:115,742,240...115,745,323
Ensembl chr 7:113,860,611...113,865,226 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21366
    protein-containing complex 6834
      mitochondrial protein-containing complex 183
        inner mitochondrial membrane protein complex 55
          uniplex complex 7
Path 2
Term Annotations click to browse term
  cellular_component 21366
    cellular anatomical structure 21071
      intracellular anatomical structure 15592
        intracellular organelle 13882
          intracellular membrane-bounded organelle 12309
            mitochondrion 2010
              mitochondrial envelope 839
                mitochondrial membrane 783
                  mitochondrial inner membrane 485
                    inner mitochondrial membrane protein complex 55
                      uniplex complex 7
paths to the root