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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid fibril formation
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Accession:GO:1990000 term browser browse the term
Definition:The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: amyloid fibril assembly;   amyloid structure assembly;   amyloid structure formation
 xref: Reactome:R-HSA-977225 "Amyloid fiber formation"


show annotations for term's descendants           Sort by:
amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in IEA
ISO		 GO_REF:0000107
(PMID:25620700), (PMID:26138908), (PMID:9737846)		 Ensembl
RGD		 PMID:9737846 PMID:25620700 PMID:26138908 GO_REF:0000107 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G B2m beta-2 microglobulin involved_in ISO
IEA		 (PMID:28468825)
GO_REF:0000107		 RGD
Ensembl		 PMID:28468825 GO_REF:0000107 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Camp cathelicidin antimicrobial peptide involved_in ISO (PMID:32753597) RGD PMID:32753597 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Cd36 CD36 molecule involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23812099)		 UniProt
Ensembl
RGD		 PMID:23812099 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd36l1 CD36 molecule like 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:12630860) RGD PMID:12630860 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdsn corneodesmosin involved_in ISO (PMID:20448140) RGD PMID:20448140 NCBI chr20:3,179,432...3,184,252
Ensembl chr20:3,179,438...3,184,250 		JBrowse link
G Cstb cystatin B involved_in ISO (PMID:16155205) RGD PMID:16155205 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526 		JBrowse link
G Emd emerin involved_in ISO (PMID:26415001) RGD PMID:26415001 NCBI chr  X:152,038,990...152,042,190
Ensembl chr  X:152,038,998...152,045,807 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:18346205) RGD PMID:18346205 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fus Fus RNA binding protein involved_in ISO (PMID:22579281), (PMID:28942918) RGD PMID:22579281 PMID:28942918 NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414 		JBrowse link
G Gsn gelsolin involved_in ISO
IEA		 (PMID:19904968), (PMID:24601799)
GO_REF:0000107		 RGD
Ensembl		 PMID:19904968 PMID:24601799 GO_REF:0000107 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Iapp islet amyloid polypeptide involved_in ISO (PMID:22944668) RGD PMID:22944668 NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G LOC134486712 platelet glycoprotein 4-like involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024
G Mapt microtubule-associated protein tau involved_in ISO (PMID:14769047), (PMID:7929085) RGD PMID:7929085 PMID:14769047 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:12630860) RGD PMID:12630860 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Nup153 nucleoporin 153 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P49790 (PMID:23238392)		 Ensembl
RGD		 PMID:23238392 GO_REF:0000107 NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO
ISS		 (PMID:22817896)
GO_REF:0000024		 RGD
UniProt		 PMID:22817896 GO_REF:0000024 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO
ISS
IEA		 (PMID:22817896)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22817896 GO_REF:0000024 GO_REF:0000107 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Serf1 small EDRK-rich factor 1 involved_in ISO (PMID:22854022), (PMID:31034892) RGD PMID:22854022 PMID:31034892 NCBI chr 2:31,475,902...31,482,030
Ensembl chr 2:31,475,703...31,482,032 		JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:8901511) RGD PMID:8901511 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Tardbp TAR DNA binding protein involved_in ISO (PMID:26735904) RGD PMID:26735904 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor involved_in ISO (PMID:34431623) RGD PMID:34431623 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISS
ISO		 GO_REF:0000024
(PMID:14741101)		 UniProt
RGD		 PMID:14741101 GO_REF:0000024 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Clu clusterin involved_in ISO
ISS
IEA		 (PMID:22179788)
(PMID:14741101)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:14741101 PMID:22179788 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cryab crystallin, alpha B involved_in ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 involved_in ISO UniProtKB:P05067-PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (PMID:20005821)		 Ensembl
RGD		 PMID:20005821 GO_REF:0000107 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mir31 microRNA 31 acts_upstream_of ISO UniProtKB:P05067 (PMID:32069773) RGD PMID:32069773 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Pfdn1 prefoldin subunit 1 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064 		JBrowse link
G Pfdn2 prefoldin subunit 2 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504 		JBrowse link
G Pfdn4 prefoldin subunit 4 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 3:159,303,173...159,311,221
Ensembl chr 3:159,303,071...159,311,219 		JBrowse link
G Pfdn5 prefoldin subunit 5 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516 		JBrowse link
G Pfdn6 prefoldin subunit 6 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30617257) RGD PMID:30617257 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Vbp1 VHL binding protein 1 involved_in ISO (PMID:23614719) RGD PMID:23614719
positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO
IEA		 (PMID:19660551)
GO_REF:0000107		 RGD
Ensembl		 PMID:19660551 GO_REF:0000107 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Psen1 presenilin 1 involved_in ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 involved_in ISO (PMID:27444016) RGD PMID:27444016 NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666 		JBrowse link
regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IEA
ISO		 GO_REF:0000107
(PMID:25207746)		 Ensembl
RGD		 PMID:25207746 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:11140685) RGD PMID:11140685 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P05067 (PMID:20164328)		 Ensembl
RGD		 PMID:20164328 GO_REF:0000107 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
Term paths to the root
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  biological_process 20536
    cellular process 19526
      metabolic process 12168
        macromolecule metabolic process 9990
          protein metabolic process 5241
            amyloid fibril formation 39
              negative regulation of amyloid fibril formation 13
              positive regulation of amyloid fibril formation 3
              regulation of amyloid fibril formation + 17
paths to the root