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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid fibril formation
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Accession:GO:1905906 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: regulation of amyloid fibril assembly;   regulation of amyloid structure assembly;   regulation of amyloid structure formation



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regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IEA
ISO
GO_REF:0000107
(PMID:25207746)
Ensembl
RGD
PMID:25207746 GO_REF:0000107 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:11140685) RGD PMID:11140685 NCBI chr11:37,506,207...37,724,351 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107 NCBI chr 1:126,123,425...126,249,181 JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISS
ISO
GO_REF:0000024
(PMID:14741101)
UniProt
RGD
PMID:14741101 GO_REF:0000024 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Clu clusterin involved_in ISO
ISS
IEA
(PMID:22179788)
(PMID:14741101)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:14741101 PMID:22179788 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315 JBrowse link
G Cryab crystallin, alpha B involved_in ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:59,989,885...59,995,532 JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 involved_in ISO UniProtKB:P05067-PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:154,960,818...155,061,971 JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (PMID:20005821)
Ensembl
RGD
PMID:20005821 GO_REF:0000107 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Mir31 microRNA 31 acts_upstream_of ISO UniProtKB:P05067 (PMID:32069773) RGD PMID:32069773 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Pfdn1 prefoldin subunit 1 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr18:28,014,145...28,067,148 JBrowse link
G Pfdn2 prefoldin subunit 2 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr13:83,772,301...83,791,367 JBrowse link
G Pfdn4 prefoldin subunit 4 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 3:159,303,173...159,311,221 JBrowse link
G Pfdn5 prefoldin subunit 5 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 7:133,451,778...133,456,516 JBrowse link
G Pfdn6 prefoldin subunit 6 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr20:4,945,959...4,947,433 JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30617257) RGD PMID:30617257 NCBI chr 9:12,647,605...12,654,190 JBrowse link
G Vbp1 VHL binding protein 1 involved_in ISO (PMID:23614719) RGD PMID:23614719
positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO
IEA
(PMID:19660551)
GO_REF:0000107
RGD
Ensembl
PMID:19660551 GO_REF:0000107 NCBI chr11:37,506,207...37,724,351 JBrowse link
G Psen1 presenilin 1 involved_in ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:109,054,160...109,106,191 JBrowse link
G Usp8 ubiquitin specific peptidase 8 involved_in ISO (PMID:27444016) RGD PMID:27444016 NCBI chr 3:113,962,136...114,009,683 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      regulation of cellular process 13013
        regulation of cellular component organization 2711
          regulation of supramolecular fiber organization 415
            regulation of amyloid fibril formation 17
              negative regulation of amyloid fibril formation 13
              positive regulation of amyloid fibril formation 3
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        regulation of cellular process 13013
          regulation of metabolic process 6834
            regulation of primary metabolic process 5693
              regulation of protein metabolic process 2024
                regulation of amyloid fibril formation 17
                  negative regulation of amyloid fibril formation 13
                  positive regulation of amyloid fibril formation 3
paths to the root