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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation



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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS
(PMID:26260791)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:9,691,452...9,711,466 JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) RGD PMID:28164773 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO UniProtKB:P05067 (PMID:24499793) RGD PMID:24499793 NCBI chr 3:160,500,748...160,520,492 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
ISO
GO_REF:0000024
(PMID:24577224)
Alzheimers_University_of_Toronto
RGD
PMID:24577224 GO_REF:0000024 NCBI chr 1:144,056,415...144,138,045 JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (PMID:23070049) RGD PMID:23070049 NCBI chr16:18,333,910...18,381,813 JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO
IEA
(PMID:24612608)
GO_REF:0000107
RGD
Ensembl
PMID:24612608 GO_REF:0000107 NCBI chr10:63,424,084...63,445,811 JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:153,245,200...153,245,297 JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,618,334...60,618,414 JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:106,570,371...106,570,451 JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (PMID:17573534) RGD PMID:17573534 NCBI chr 3:139,639,076...139,654,420 JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) RGD PMID:24305806 PMID:27853422 NCBI chr18:1,387,360...1,509,218 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385)
(PMID:18362153)
RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 NCBI chr 8:51,238,713...51,401,458 JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(PMID:18429932), (PMID:23467355), (PMID:27030769)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 NCBI chr 7:9,691,452...9,711,466 JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA
(PMID:24154541)
(PMID:24259049)
GO_REF:0000107
RGD
Ensembl
PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA
(PMID:27179792)
GO_REF:0000107
RGD
Ensembl
PMID:27179792 GO_REF:0000107 NCBI chr18:24,009,731...24,067,267 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:12047389), (PMID:17412999)
Alzheimers_University_of_Toronto
Ensembl
RGD
PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315 JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:100,825,427...100,843,422 JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:85,778,267...85,786,553 JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107
RGD
Ensembl
PMID:27277332 GO_REF:0000107 NCBI chr 7:24,169,608...24,249,446 JBrowse link
G Mir103a1 microRNA 103a-1 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr10:20,244,412...20,244,497 JBrowse link
G Mir103a2 microRNA 103a-2 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr 3:118,510,194...118,510,279 JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:22733824) RGD PMID:22733824 NCBI chr 6:138,163,595...138,163,681 JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:153,245,200...153,245,297 JBrowse link
G Mir16-2 microRNA 16-2 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr 2:153,245,349...153,245,443 JBrowse link
G Mir186 microRNA 186 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr 2:246,582,806...246,582,891 JBrowse link
G Mir24-2 microRNA 24-2 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr19:23,954,683...23,954,790 JBrowse link
G Mir298 microRNA 298 acts_upstream_of ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:163,052,291...163,052,372 JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,618,334...60,618,414 JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:106,570,371...106,570,451 JBrowse link
G Mir339 microRNA 339 acts_upstream_of ISO (PMID:24352696) RGD PMID:24352696 NCBI chr12:15,277,546...15,277,641 JBrowse link
G Mir361 microRNA 361 involved_in ISO (PMID:31601077) RGD PMID:31601077 NCBI chr  X:78,246,206...78,246,275 JBrowse link
G Mir455 microRNA 455 acts_upstream_of ISO (PMID:25100943), (PMID:31181293) RGD PMID:25100943 PMID:31181293 NCBI chr 5:76,689,313...76,689,390 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P05067-4 (PMID:26094765)
Ensembl
RGD
PMID:26094765 GO_REF:0000107 NCBI chr17:5,560,558...5,875,899 JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(PMID:16554819)
RGD PMID:16554819 PMID:25576397 NCBI chr 8:27,465,538...27,477,016 JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (PMID:17573534) RGD PMID:17573534 NCBI chr 3:139,639,076...139,654,420 JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA
(PMID:24305806), (PMID:27853422)
GO_REF:0000107
RGD
Ensembl
PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,387,360...1,509,218 JBrowse link
G Rtn1 reticulon 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15286784)
UniProt
Ensembl
RGD
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:96,499,137...96,719,340 JBrowse link
G Rtn2 reticulon 2 involved_in ISO
ISS
(PMID:15286784)
GO_REF:0000024
RGD
UniProt
PMID:15286784 GO_REF:0000024 NCBI chr 1:78,935,056...78,948,069 JBrowse link
G Rtn3 reticulon 3 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15286784)
UniProt
Ensembl
RGD
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:204,612,675...204,669,212 JBrowse link
G Rtn4 reticulon 4 involved_in ISO
IEA
ISS
(PMID:15286784)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:103,450,074...103,497,687 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:18362153), (PMID:19036982)
(PMID:16174740), (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
RGD PMID:16174740 PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 More... NCBI chr 8:51,238,713...51,401,458 JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:16227578)
Ensembl
RGD
PMID:16227578 GO_REF:0000107 NCBI chr 1:177,363,526...177,662,689 JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) RGD PMID:27179792 NCBI chr18:24,009,731...24,067,267 JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) RGD PMID:16641999 NCBI chr 6:110,722,887...110,757,743 JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO UniProtKB:P56818 (PMID:20704561), (PMID:22086926) RGD PMID:20704561 PMID:22086926 NCBI chr 3:28,642,660...28,662,689 JBrowse link
G Ager advanced glycosylation end product-specific receptor involved_in ISO UniProtKB:P05067-PRO_0000000093 (PMID:22406537) RGD PMID:22406537 NCBI chr20:4,152,758...4,155,956 JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:Q15109 (PMID:22406537) RGD PMID:22406537 NCBI chr11:37,506,207...37,724,351 JBrowse link
G Efna1 ephrin A1 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:174,681,676...174,689,061 JBrowse link
G Efna3 ephrin A3 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:174,729,192...174,738,111 JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827|UniProtKB:P52797 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:86,263,982...86,406,744 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 5:21,437,127...21,553,097 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
ISO
GO_REF:0000024
(PMID:22539346)
Alzheimers_University_of_Toronto
RGD
PMID:22539346 GO_REF:0000024 NCBI chr 1:144,056,415...144,138,045 JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of IGI PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr17:21,220,807...21,303,009 JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:24305806) RGD PMID:24305806 NCBI chr 6:45,407,823...45,502,773 JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:16227578)
Ensembl
RGD
PMID:16227578 GO_REF:0000107 NCBI chr 1:177,363,526...177,662,689 JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
ISO
IEA
IMP
(PMID:22086926)
GO_REF:0000107
RGD
Ensembl
PMID:22086926 PMID:22086926 GO_REF:0000107, RGD:14697726 NCBI chr 3:28,642,660...28,662,689 JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,128,056...9,184,312 JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541 PMID:24259049 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Casp3 caspase 3 involved_in IDA
ISO
PMID:17553422
(PMID:17553422)
RGD PMID:17553422 PMID:17553422 RGD:13825190 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:12145324)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:12145324 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315 JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:112,863,726...112,887,338 JBrowse link
G Efna1 ephrin A1 involved_in ISO
IEA
(PMID:24217950)
GO_REF:0000107
RGD
Ensembl
PMID:24217950 GO_REF:0000107 NCBI chr 2:174,681,676...174,689,061 JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:86,263,982...86,406,744 JBrowse link
G Gsap gamma-secretase activating protein involved_in ISO
IBA
(PMID:20811458)
GO_REF:0000033
RGD
GO_Central
PMID:20811458 GO_REF:0000033 NCBI chr 4:13,813,046...13,907,875 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO
IEA
UniProtKB:P49841 (PMID:12761548)
GO_REF:0000107
RGD
Ensembl
PMID:12761548 GO_REF:0000107 NCBI chr 1:89,943,669...89,953,514 JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (PMID:17255335)
RGD PMID:17255335 PMID:19808651 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01579|UniProtKB:P05067 (PMID:17255335) RGD PMID:17255335 NCBI chr 1:16,152,811...16,171,439 JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within ISO (PMID:17098871) RGD PMID:17098871 NCBI chr20:24,515,627...24,689,669 JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:27277332) RGD PMID:27277332 NCBI chr 9:23,094,249...23,094,332 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
IEA
(PMID:24577224)
(PMID:22539346), (PMID:24577224)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:22539346 PMID:24577224 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:144,056,415...144,138,045 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of ISO (PMID:21329555) RGD PMID:21329555 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO
IEA
(PMID:24305806)
GO_REF:0000107
RGD
Ensembl
PMID:24305806 GO_REF:0000107 NCBI chr 6:45,407,823...45,502,773 JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO UniProtKB:P05067-4 (PMID:26094765) RGD PMID:26094765 NCBI chr 7:122,399,329...122,726,605 JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO (PMID:14701757) RGD PMID:14701757 NCBI chr 7:135,419,864...135,450,513 JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) RGD PMID:17255335 NCBI chr20:3,626,685...3,629,303 JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO UniProtKB:P05067-PRO_0000000092 (PMID:26005850) RGD PMID:26005850 NCBI chr 1:144,056,415...144,138,045 JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO
IEA
ISS
(PMID:16641999)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:16641999 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:110,722,887...110,757,743 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    regulation of biological process 13375
      regulation of cellular process 13013
        regulation of metabolic process 6834
          regulation of macromolecule metabolic process 6302
            regulation of protein metabolic process 2024
              regulation of amyloid precursor protein catabolic process 59
                negative regulation of amyloid precursor protein catabolic process + 34
                positive regulation of amyloid precursor protein catabolic process + 27
                regulation of amyloid-beta formation + 51
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        regulation of cellular process 13013
          regulation of metabolic process 6834
            regulation of primary metabolic process 5693
              regulation of protein metabolic process 2024
                regulation of amyloid precursor protein catabolic process 59
                  negative regulation of amyloid precursor protein catabolic process + 34
                  positive regulation of amyloid precursor protein catabolic process + 27
                  regulation of amyloid-beta formation + 51
paths to the root