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ONTOLOGY REPORT - ANNOTATIONS

Term:very-long-chain 3-oxoacyl-CoA reductase activity
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Accession:GO:0141040 term browser browse the term
Definition:Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH. This reaction is the second (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.
Synonyms:xref: EC:1.1.1.330;   MetaCyc:RXN-7698;   RHEA:48680;   Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA"


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very-long-chain 3-oxoacyl-CoA reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 enables ISO (PMID:12482854), (PMID:25003994) RGD PMID:12482854 PMID:25003994 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
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  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            very-long-chain 3-oxoacyl-CoA reductase activity 1
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