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ONTOLOGY REPORT - ANNOTATIONS


Term:protein-containing complex destabilizing activity
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Accession:GO:0140776 term browser browse the term
Definition:A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex.
Synonyms:broad_synonym: protein unfoldase activity



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protein-containing complex destabilizing activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notum NOTUM, palmitoleoyl-protein carboxylesterase enables ISO (PMID:25771893) RGD PMID:25771893 NCBI chr10:105,933,245...105,940,327
Ensembl chr10:105,933,249...105,940,315
JBrowse link
ATP-dependent protein disaggregase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clpb ClpB family mitochondrial disaggregase enables ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:32573439), (PMID:34115842)
UniProt
Ensembl
RGD
PMID:32573439 PMID:34115842 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A enables ISO (PMID:23921388) RGD PMID:23921388 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B enables ISO (PMID:23921388) RGD PMID:23921388 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 enables ISO (PMID:23921388) RGD PMID:23921388 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase enables ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
JBrowse link
microtubule severing ATPase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fign fidgetin, microtubule severing factor enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:48,637,510...48,760,772
Ensembl chr 3:48,642,496...48,760,787
JBrowse link
G Fignl1 fidgetin-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455
JBrowse link
G Katna1 katanin catalytic subunit A1 enables IEA
ISO
GO_REF:0000003
GO_REF:0000107
(PMID:10751153)
UniProt
Ensembl
RGD
PMID:10751153 GO_REF:0000003 GO_REF:0000107 NCBI chr 1:2,202,501...2,244,132
Ensembl chr 1:2,202,490...2,244,131
JBrowse link
G Katnal1 katanin catalytic subunit A1 like 1 enables ISO
ISS
(PMID:26929214)
(PMID:22654668)
GO_REF:0000024
RGD
UniProt
PMID:22654668 PMID:26929214 GO_REF:0000024 NCBI chr12:6,094,663...6,156,114
Ensembl chr12:6,102,836...6,157,553
JBrowse link
G Katnal2 katanin catalytic subunit A1 like 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:70,531,759...70,607,886
Ensembl chr18:70,531,754...70,608,082
JBrowse link
G Spast spastin enables IEA
ISS
ISO
GO_REF:0000003
GO_REF:0000104
GO_REF:0000024
(PMID:15716377), (PMID:16219033), (PMID:17389232), (PMID:23745751), (PMID:26875866)
UniProt
RGD
PMID:15716377 PMID:16219033 PMID:17389232 PMID:23745751 PMID:26875866 GO_REF:0000003 GO_REF:0000024 GO_REF:0000104 NCBI chr 6:21,055,349...21,106,586
Ensembl chr 6:21,055,349...21,107,954
JBrowse link

Term paths to the root
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  molecular_function 20634
    protein-containing complex destabilizing activity 12
      ATP-dependent protein disaggregase activity 5
      actin filament debranching activity 0
      actin filament severing activity 0
      microtubule destablizing activity + 6
paths to the root