ONTOLOGY REPORT - ANNOTATIONS
Term: protein-containing complex destabilizing activity
Accession: GO:0140776
browse the term
Definition: A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex.
Synonyms: broad_synonym: protein unfoldase activity
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Notum
NOTUM, palmitoleoyl-protein carboxylesterase
enables
ISO
(PMID:25771893)
RGD
PMID:25771893
NCBI chr10:105,933,245...105,940,327
Ensembl chr10:105,933,249...105,940,315
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Clpb
ClpB family mitochondrial disaggregase
enables
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:32573439), (PMID:34115842)
UniProt Ensembl RGD
PMID:32573439 PMID:34115842
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788
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Hspa1a
heat shock protein family A (Hsp70) member 1A
enables
ISO
(PMID:23921388)
RGD
PMID:23921388
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa1b
heat shock protein family A (Hsp70) member 1B
enables
ISO
(PMID:23921388)
RGD
PMID:23921388
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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Hspa8
heat shock protein family A (Hsp70) member 8
enables
ISO
(PMID:23921388)
RGD
PMID:23921388
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
enables
ISS
GO_REF:0000024
ParkinsonsUK-UCL
GO_REF:0000024
NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
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Fign
fidgetin, microtubule severing factor
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:48,637,510...48,760,772
Ensembl chr 3:48,642,496...48,760,787
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Fignl1
fidgetin-like 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455
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Katna1
katanin catalytic subunit A1
enables
IEA ISO
GO_REF:0000003 GO_REF:0000107 (PMID:10751153)
UniProt Ensembl RGD
PMID:10751153
GO_REF:0000003 GO_REF:0000107
NCBI chr 1:2,202,501...2,244,132
Ensembl chr 1:2,202,490...2,244,131
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Katnal1
katanin catalytic subunit A1 like 1
enables
ISO ISS
(PMID:26929214) (PMID:22654668) GO_REF:0000024
RGD UniProt
PMID:22654668 PMID:26929214
GO_REF:0000024
NCBI chr12:6,094,663...6,156,114
Ensembl chr12:6,102,836...6,157,553
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Katnal2
katanin catalytic subunit A1 like 2
enables
IEA
GO_REF:0000003
UniProt
GO_REF:0000003
NCBI chr18:70,531,759...70,607,886
Ensembl chr18:70,531,754...70,608,082
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Spast
spastin
enables
IEA ISS ISO
GO_REF:0000003 GO_REF:0000104 GO_REF:0000024 (PMID:15716377), (PMID:16219033), (PMID:17389232), (PMID:23745751), (PMID:26875866)
UniProt RGD
PMID:15716377 PMID:16219033 PMID:17389232 PMID:23745751 PMID:26875866
GO_REF:0000003 GO_REF:0000024 GO_REF:0000104
NCBI chr 6:21,055,349...21,106,586
Ensembl chr 6:21,055,349...21,107,954
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