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ONTOLOGY REPORT - ANNOTATIONS

Term:granzyme-mediated programmed cell death signaling pathway
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Accession:GO:0140507 term browser browse the term
Definition:The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
Synonyms:broad_synonym: granzyme-mediated cell death signaling pathway


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granzyme-mediated programmed cell death signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07018028.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr15:30,289,611...30,291,562 JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO
IEA		 (PMID:9396766)
GO_REF:0000107		 RGD
Ensembl		 PMID:9396766 GO_REF:0000107 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:31953257), (PMID:32188940) RGD PMID:31953257 PMID:32188940 NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Gzma granzyme A involved_in ISO
IBA
IEA		 (PMID:32299851), (PMID:34022140)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:32299851 PMID:34022140 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
G Gzmb granzyme B involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA		 GO_REF:0000024
(PMID:20038786), (PMID:31953257), (PMID:32188940), (PMID:9852092)
(PMID:35705808)
MGI:1857156 (PMID:15454490), (PMID:16618603)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:9852092 PMID:15454490 PMID:16618603 PMID:20038786 PMID:31953257 More... GO_REF:0000024 GO_REF:0000033 NCBI chr15:34,459,007...34,462,469
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Gzmc-ps2 granzyme C, pseudogene 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:34,359,939...34,370,593
Ensembl chr15:30,240,621...30,251,349
Ensembl chr15:30,240,621...30,251,349 		JBrowse link
G Gzmk granzyme K involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:46,573,997...46,582,015
Ensembl chr 2:44,840,811...44,848,894 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO
IEA		 (PMID:23632890)
GO_REF:0000107		 RGD
Ensembl		 PMID:23632890 GO_REF:0000107 NCBI chr16:83,058,131...83,082,843
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G LOC102553861 granzyme-like protein 1-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr15:30,173,603...30,346,814 JBrowse link
G Nkg7 natural killer cell granule protein 7 involved_in ISO (PMID:33911019) RGD PMID:33911019 NCBI chr 1:102,981,497...102,982,564
Ensembl chr 1:93,844,902...93,845,983 		JBrowse link
G Prf1 perforin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:35705808)		 Ensembl
RGD		 PMID:35705808 GO_REF:0000107 NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Srgn serglycin involved_in ISO
ISS		 (PMID:11911826)
GO_REF:0000024		 RGD
UniProt		 PMID:11911826 GO_REF:0000024 NCBI chr20:30,985,508...31,022,296
Ensembl chr20:30,442,813...30,457,406 		JBrowse link
granzyme-mediated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube4b ubiquitination factor E4B involved_in ISO
IEA		 (PMID:11802788)
GO_REF:0000107		 RGD
Ensembl		 PMID:11802788 GO_REF:0000107 NCBI chr 5:165,049,897...165,153,572
Ensembl chr 5:159,766,829...159,870,509 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      signal transduction 7301
        granzyme-mediated programmed cell death signaling pathway 13
          granzyme-mediated apoptotic signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          signal transduction 7301
            granzyme-mediated programmed cell death signaling pathway 13
              granzyme-mediated apoptotic signaling pathway 1
paths to the root