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ONTOLOGY REPORT - ANNOTATIONS


Term:P-type transmembrane transporter activity
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Accession:GO:0140358 term browser browse the term
Definition:Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
Synonyms:exact_synonym: E1-E2 ATPase;   P-type ATPase
 xref: TC:3.A.3;   Wikipedia:P-type_ATPase


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P-type transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a1 ATPase 13A1 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936596:1,842,469...1,859,379
Ensembl chrNW_004936596:1,842,480...1,859,389
JBrowse link
G Atp13a3 ATPase 13A3 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936711:325,978...400,374
Ensembl chrNW_004936711:354,020...397,145
JBrowse link
G Atp13a4 ATPase 13A4 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936711:1,151,847...1,275,517
Ensembl chrNW_004936711:1,151,943...1,275,518
JBrowse link
G Atp13a5 ATPase 13A5 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936711:1,294,974...1,402,797
Ensembl chrNW_004936711:1,294,892...1,402,793
JBrowse link
P-type calcium transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 ISO RGD PMID:9299392 RGD:10053703 NCBI chrNW_004936662:926,302...959,964
Ensembl chrNW_004936662:925,940...939,451
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 enables ISO
IEA
RGD
UniProt
Ensembl
RHEA
InterPro
PMID:12222829 PMID:12409282 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 RGD:724593 RGD:727704 NCBI chrNW_004936501:11,818,301...11,836,221
Ensembl chrNW_004936501:11,816,585...11,836,231
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 enables ISO
IEA
RGD
Ensembl
UniProt
InterPro
RHEA
PMID:12409282 PMID:21300842 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 RGD:6904139 RGD:724593 NCBI chrNW_004936558:3,300,941...3,357,595
Ensembl chrNW_004936558:3,300,941...3,357,941
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 enables IEA InterPro
UniProt
Ensembl
RHEA
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chrNW_004936677:552,066...585,093
Ensembl chrNW_004936677:551,933...585,114
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 enables IEA UniProt
TreeGrafter
InterPro
RHEA
GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000118 NCBI chrNW_004936507:6,525,302...6,631,003
Ensembl chrNW_004936507:6,523,199...6,630,606
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 enables ISO
IEA
RGD
TreeGrafter
UniProt
RHEA
InterPro
PMID:2837461 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000118 RGD:631720 NCBI chrNW_004936602:2,744,757...3,011,051
Ensembl chrNW_004936602:2,744,759...3,007,940
JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 enables IEA RHEA
TreeGrafter
InterPro
UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000118 NCBI chrNW_004936809:396,883...466,372
Ensembl chrNW_004936809:396,733...466,524
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 enables ISO
IEA
RGD
TreeGrafter
UniProt
InterPro
RHEA
Ensembl
PMID:11779484 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:628395 NCBI chrNW_004936567:944,825...1,039,920
Ensembl chrNW_004936567:950,797...993,245
JBrowse link
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 enables
NOT|enables
ISO
IEA
(PMID:16192278) RGD
InterPro
Ensembl
UniProt
RHEA
UniProt
PMID:15328051 PMID:16192278 PMID:19527224 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 RGD:1581800 RGD:7241224 NCBI chrNW_004936529:4,340,131...4,474,884
Ensembl chrNW_004936529:4,361,424...4,474,436
JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:3,498,693...3,547,968
Ensembl chrNW_004936641:3,498,693...3,547,968
JBrowse link
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:3,300,941...3,357,595
Ensembl chrNW_004936558:3,300,941...3,357,941
JBrowse link
P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936602:2,744,757...3,011,051
Ensembl chrNW_004936602:2,744,759...3,007,940
JBrowse link
P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936809:396,883...466,372
Ensembl chrNW_004936809:396,733...466,524
JBrowse link
P-type divalent copper transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha enables ISO (PMID:15634671) MGI PMID:15634671 NCBI chrNW_004936683:2,874,022...2,936,214
Ensembl chrNW_004936683:2,874,042...2,935,040
JBrowse link
G Atp7b ATPase copper transporting beta enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936565:4,694,294...4,763,661
Ensembl chrNW_004936565:4,694,281...4,763,773
JBrowse link
P-type ion transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a1 ATPase 13A1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936596:1,842,469...1,859,379
Ensembl chrNW_004936596:1,842,480...1,859,389
JBrowse link
G Atp13a2 ATPase cation transporting 13A2 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936474:3,968,216...3,980,821
Ensembl chrNW_004936474:3,968,506...3,980,815
JBrowse link
G Atp13a4 ATPase 13A4 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936711:1,151,847...1,275,517
Ensembl chrNW_004936711:1,151,943...1,275,518
JBrowse link
G Atp13a5 ATPase 13A5 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936711:1,294,974...1,402,797
Ensembl chrNW_004936711:1,294,892...1,402,793
JBrowse link
P-type magnesium transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmem94 transmembrane protein 94 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:695,180...729,723
Ensembl chrNW_004936594:695,175...730,999
JBrowse link
P-type manganese transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 enables IEA RHEA
Ensembl
GO_REF:0000107 GO_REF:0000116 NCBI chrNW_004936529:4,340,131...4,474,884
Ensembl chrNW_004936529:4,361,424...4,474,436
JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:3,498,693...3,547,968
Ensembl chrNW_004936641:3,498,693...3,547,968
JBrowse link
P-type monovalent copper transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha enables IEA UniProt
Ensembl
GO_REF:0000003 GO_REF:0000107 NCBI chrNW_004936683:2,874,022...2,936,214
Ensembl chrNW_004936683:2,874,042...2,935,040
JBrowse link
G Atp7b ATPase copper transporting beta enables IEA UniProt GO_REF:0000003 NCBI chrNW_004936565:4,694,294...4,763,661
Ensembl chrNW_004936565:4,694,281...4,763,773
JBrowse link
P-type potassium transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936720:2,363,933...2,378,426
Ensembl chrNW_004936720:2,363,933...2,378,426
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 enables IEA InterPro
Ensembl
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936740:489,357...514,235
Ensembl chrNW_004936740:488,154...514,308
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936706:476,473...494,659
Ensembl chrNW_004936706:477,107...495,525
JBrowse link
G LOC101966280 sodium/potassium-transporting ATPase subunit alpha-4 enables IEA InterPro GO_REF:0000002 NCBI chrNW_004936740:445,952...478,580
Ensembl chrNW_004936740:445,952...478,532
JBrowse link
P-type potassium:proton transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit contributes_to
enables
ISO
IEA
RGD
UniProt
Ensembl
PMID:16046397 GO_REF:0000003 GO_REF:0000107 RGD:2301240 NCBI chrNW_004936720:2,363,933...2,378,426
Ensembl chrNW_004936720:2,363,933...2,378,426
JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha enables IEA InterPro
TreeGrafter
Ensembl
UniProt
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936570:802,170...815,023
Ensembl chrNW_004936570:802,170...814,056
JBrowse link
P-type sodium:potassium-exchanging transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936720:2,363,933...2,378,426
Ensembl chrNW_004936720:2,363,933...2,378,426
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 enables ISO
IEA
RGD
TreeGrafter
Ensembl
PMID:12531906 PMID:16624992 PMID:16893515 GO_REF:0000107 GO_REF:0000118 RGD:1581763 RGD:2302992 RGD:629542 NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 enables ISO
IEA
RGD
TreeGrafter
Ensembl
PMID:16624992 GO_REF:0000107 GO_REF:0000118 RGD:2302992 NCBI chrNW_004936740:489,357...514,235
Ensembl chrNW_004936740:488,154...514,308
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936706:476,473...494,659
Ensembl chrNW_004936706:477,107...495,525
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 enables ISO
IEA
RGD
Ensembl
PMID:16624992 GO_REF:0000107 RGD:2302992 NCBI chrNW_004936481:17,438,146...17,460,329
Ensembl chrNW_004936481:17,436,270...17,460,348
JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 ISO RGD PMID:12562669 RGD:631758 NCBI chrNW_004936595:908,019...914,426
Ensembl chrNW_004936595:907,919...915,053
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 ISO RGD PMID:12562669 PMID:16624992 RGD:2302992 RGD:631758 NCBI chrNW_004936540:3,621,656...3,640,885 JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936570:802,170...815,023
Ensembl chrNW_004936570:802,170...814,056
JBrowse link
G LOC101966280 sodium/potassium-transporting ATPase subunit alpha-4 enables IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936740:445,952...478,580
Ensembl chrNW_004936740:445,952...478,532
JBrowse link
P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 enables ISO (PMID:19376779) BHF-UCL PMID:19376779 NCBI chrNW_004936706:476,473...494,659
Ensembl chrNW_004936706:477,107...495,525
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17124
    ATP-dependent activity 569
      ATPase-coupled transmembrane transporter activity 105
        P-type transmembrane transporter activity 27
          P-type ion transporter activity + 26
Path 2
Term Annotations click to browse term
  molecular_function 17124
    transporter activity 1142
      transmembrane transporter activity 1050
        active transmembrane transporter activity 386
          primary active transmembrane transporter activity 136
            ATPase-coupled transmembrane transporter activity 105
              P-type transmembrane transporter activity 27
                P-type ion transporter activity + 26
paths to the root