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ONTOLOGY REPORT - ANNOTATIONS

Term:P-type transmembrane transporter activity
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Accession:GO:0140358 term browser browse the term
Definition:Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
Synonyms:exact_synonym: E1-E2 ATPase;   P-type ATPase
 xref: TC:3.A.3;   Wikipedia:P-type_ATPase


show annotations for term's descendants           Sort by:
P-type transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a3 ATPase 13A3 enables ISO (PMID:33310703) RGD PMID:33310703 NCBI chr11:70,364,998...70,442,005
Ensembl chr11:70,365,322...70,441,235 		JBrowse link
G Atp13a4 ATPase 13A4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:71,222,196...71,359,933
Ensembl chr11:71,226,161...71,359,933 		JBrowse link
G Atp13a5 ATPase 13A5 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:71,376,388...71,515,789
Ensembl chr11:71,376,422...71,515,789 		JBrowse link
P-type calcium transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07005775.1 enables IEA GO_REF:0000002
GO_REF:0000107		 InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107
G Anxa5 annexin A5 IDA RGD PMID:9299392 RGD:10053703 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 enables IDA
IBA
IEA
ISS
ISO		 GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
PMID:9887021
GO_REF:0000024
(PMID:1329967)
(PMID:8729696)
PMID:9843705		 GO_Central
Ensembl
InterPro
UniProt
RGD		 PMID:1329967 PMID:8729696 PMID:12222829 PMID:9887021 PMID:9843705 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:727704, RGD:8554277, RGD:14995324, RGD:724593 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 enables IDA
IEA
ISO		 PMID:9851937
GO_REF:0000107
(PMID:12756243), (PMID:29475982), (PMID:31819041), (PMID:9887021)
(PMID:16402920)		 Ensembl
RGD		 PMID:9887021 PMID:12756243 PMID:16402920 PMID:29475982 PMID:31819041 More... GO_REF:0000107, RGD:724593, RGD:10047146, RGD:6904139 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 enables IEA
IBA
IDA
ISO		 GO_REF:0000003
GO_REF:0000033
PMID:9843705
(PMID:9843705)
GO_REF:0000116		 UniProt
GO_Central
RGD
RHEA		 PMID:9843705 PMID:9843705 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116, RGD:14995324 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 enables IC
IBA
IEA
TAS		 GO_REF:0000033
GO_REF:0000002
Reactome:R-RNO-9664221		 GO_Central
InterPro
Reactome
RGD		 PMID:9227424 GO_REF:0000002 GO_REF:0000033 Reactome:R-RNO-9664221, RGD:2317732 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 enables IDA
IBA
IEA
ISO
TAS
ISS		 GO_REF:0000033
GO_REF:0000002
(PMID:7929331)
GO_REF:0000116
GO_REF:0000003
Reactome:R-RNO-9664232
GO_REF:0000024		 GO_Central
InterPro
RGD
RHEA
UniProt
Reactome		 PMID:7929331 PMID:2837461 PMID:2837461 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 Reactome:R-RNO-9664232, RGD:631720, RGD:631720 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr  X:151,216,483...151,289,069
Ensembl chr  X:151,216,507...151,286,775 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 enables IDA
IBA
IEA
ISO
IC		 GO_REF:0000033
GO_REF:0000002
(PMID:8530416)		 GO_Central
InterPro
RGD		 PMID:8530416 PMID:11779484 PMID:9227424 GO_REF:0000002 GO_REF:0000033, RGD:628395, RGD:2317732 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 enables
NOT|enables		 IDA
IBA
IEA
ISO
ISS		 GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
(PMID:16192278)
(PMID:12707275)
GO_REF:0000024
(PMID:10615129), (PMID:12810057)
GO_REF:0000116
GO_REF:0000003		 GO_Central
Ensembl
InterPro
RGD
UniProt
RHEA		 PMID:10615129 PMID:12707275 PMID:12810057 PMID:16192278 PMID:15328051 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:1581800, RGD:7241224 NCBI chr 8:106,034,777...106,155,854
Ensembl chr 8:106,034,636...106,156,006 		JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 enables IEA
IBA
ISO
ISS		 GO_REF:0000116
GO_REF:0000033
(PMID:15677451), (PMID:15831496)
GO_REF:0000024
GO_REF:0000003		 RHEA
GO_Central
RGD
UniProt		 PMID:15677451 PMID:15831496 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 NCBI chr19:47,754,120...47,811,369
Ensembl chr19:47,754,120...47,811,368 		JBrowse link
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 enables ISO
ISS
IBA		 (PMID:28890335)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:28890335 GO_REF:0000024 GO_REF:0000033 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 enables ISO (PMID:7929331) RGD PMID:7929331 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 enables ISO
IEA		 (PMID:18029012)
GO_REF:0000107		 RGD
Ensembl		 PMID:18029012 GO_REF:0000107 NCBI chr  X:151,216,483...151,289,069
Ensembl chr  X:151,216,507...151,286,775 		JBrowse link
P-type divalent copper transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha enables IBA
ISO		 GO_REF:0000033
(PMID:15634671)		 GO_Central
RGD		 PMID:15634671 GO_REF:0000033 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp7b ATPase copper transporting beta enables ISO
IBA
IEA
ISS		 (PMID:9837819)
MGI:1856220 (PMID:11237756), (PMID:15634671)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:9837819 PMID:11237756 PMID:15634671 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
P-type ion transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a1 ATPase 13A1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:19,615,156...19,631,546
Ensembl chr16:19,615,160...19,631,214 		JBrowse link
G Atp13a2 ATPase cation transporting 13A2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139 		JBrowse link
G Atp13a3 ATPase 13A3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:70,364,998...70,442,005
Ensembl chr11:70,365,322...70,441,235 		JBrowse link
G Atp13a4 ATPase 13A4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:71,222,196...71,359,933
Ensembl chr11:71,226,161...71,359,933 		JBrowse link
G Atp13a5 ATPase 13A5 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:71,376,388...71,515,789
Ensembl chr11:71,376,422...71,515,789 		JBrowse link
P-type magnesium transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmem94 transmembrane protein 94 enables ISO (PMID:38513662) RGD PMID:38513662 NCBI chr10:100,991,523...101,027,046
Ensembl chr10:100,991,573...101,027,394 		JBrowse link
P-type manganese transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000116
(PMID:21187401)		 UniProt
Ensembl
RHEA
RGD		 PMID:21187401 GO_REF:0000024 GO_REF:0000107 GO_REF:0000116 NCBI chr 8:106,034,777...106,155,854
Ensembl chr 8:106,034,636...106,156,006 		JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 enables ISO
IEA		 (PMID:15831496)
GO_REF:0000116		 RGD
RHEA		 PMID:15831496 GO_REF:0000116 NCBI chr19:47,754,120...47,811,369
Ensembl chr19:47,754,120...47,811,368 		JBrowse link
P-type monovalent copper transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha enables ISS
ISO		 GO_REF:0000024
(PMID:10419525)		 UniProt
RGD		 PMID:10419525 GO_REF:0000024 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp7b ATPase copper transporting beta enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
P-type potassium transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 enables ISO (PMID:23229519) RGD PMID:23229519 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
P-type potassium:proton transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit contributes_to
enables		 IDA
ISO
IEA		 (PMID:8853415)
GO_REF:0000003		 RGD
UniProt		 PMID:8853415 PMID:16046397 GO_REF:0000003, RGD:2301240 NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229 		JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha enables TAS
ISO
IBA
IEA		 (PMID:7762614)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000003		 RGD
GO_Central
InterPro
UniProt		 PMID:7762614 PMID:3023364 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033, RGD:631722 NCBI chr 1:85,961,607...85,974,972
Ensembl chr 1:85,961,708...85,974,844 		JBrowse link
P-type proton-exporting transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6v1g2 ATPase H+ transporting V1 subunit G2 TAS RGD PMID:11904681 RGD:632223 NCBI chr20:3,587,681...3,591,309
Ensembl chr20:3,587,686...3,590,481 		JBrowse link
P-type sodium:potassium-exchanging transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:9774385)		 UniProt
GO_Central
RGD		 PMID:9774385 GO_REF:0000024 GO_REF:0000033 NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 enables IDA
ISO
IEA
IBA		 (PMID:10360172), (PMID:15485817), (PMID:23229519)
UniProtKB:P05027 (PMID:10636900), (PMID:18052210), (PMID:19542013)
(PMID:18075585), (PMID:19542013)
PMID:17939993
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:10360172 PMID:10636900 PMID:15485817 PMID:18052210 PMID:18075585 More... GO_REF:0000033 GO_REF:0000107, RGD:629542, RGD:1581763, RGD:2302992, RGD:10047180, RGD:8554378 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 enables IDA
IBA
ISO		 GO_REF:0000033
UniProtKB:P05026|UniProtKB:P05027 (PMID:10636900), (PMID:12539047), (PMID:18052210), (PMID:18728015), (PMID:20100892), (PMID:23954377)		 GO_Central
RGD		 PMID:10636900 PMID:12539047 PMID:18052210 PMID:18728015 PMID:20100892 More... GO_REF:0000033, RGD:2302992 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 enables NAS
ISO
IBA
IEA
ISS		 PMID:26224839
(PMID:19666602), (PMID:21418141)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
(PMID:10636900), (PMID:15260953)		 RGD
GO_Central
Ensembl
UniProt		 PMID:10636900 PMID:15260953 PMID:19666602 PMID:21418141 PMID:26224839 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:11576284 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 enables TAS
ISO
IBA
IEA
IDA		 MGI:4941050 (PMID:21187400), (PMID:23229519)
GO_REF:0000033
GO_REF:0000107
PMID:10555956
UniProtKB:P05026|UniProtKB:P54709 (PMID:16861705)		 RGD
GO_Central
Ensembl		 PMID:16861705 PMID:21187400 PMID:23229519 PMID:12112599 PMID:10555956 GO_REF:0000033 GO_REF:0000107, RGD:728364, RGD:8553802 NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 enables IDA
ISO
IEA		 (PMID:19542013)
GO_REF:0000107		 RGD
Ensembl		 PMID:19542013 PMID:16624992 GO_REF:0000107, RGD:2302992 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 IDA RGD PMID:12562669 RGD:631758 NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 IDA
IC
TAS		 RGD PMID:12562669 PMID:16624992 PMID:15327400 PMID:12562669 RGD:631758, RGD:2302992, RGD:2302991, RGD:631758 NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598 		JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:85,961,607...85,974,972
Ensembl chr 1:85,961,708...85,974,844 		JBrowse link
G Myh9 myosin, heavy chain 9 enables ISS PMID:2477373 UniProt PMID:2477373 RGD:8554445 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457 		JBrowse link
P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 enables ISO UniProtKB:A2ASQ1 (MGI:4352602|PMID:19376779)
UniProtKB:A2ASQ1 (PMID:19376779)		 RGD PMID:19376779 MGI:4352602 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    ATP-dependent activity 628
      ATPase-coupled transmembrane transporter activity 117
        P-type transmembrane transporter activity 30
          P-type ion transporter activity + 30
Path 2
Term Annotations click to browse term
  molecular_function 20736
    transporter activity 1234
      transmembrane transporter activity 1136
        active transmembrane transporter activity 443
          primary active transmembrane transporter activity 151
            ATPase-coupled transmembrane transporter activity 117
              P-type transmembrane transporter activity 30
                P-type ion transporter activity + 30
paths to the root