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ONTOLOGY REPORT - ANNOTATIONS

Term:mechanosensitive monoatomic cation channel activity
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Accession:GO:0140135 term browser browse the term
Definition:Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress.
Synonyms:exact_synonym: mechanically-gated cation channel activity
 broad_synonym: mechanosensitive cation channel activity
 xref: Reactome:R-HSA-9659380 "Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell";   Reactome:R-HSA-9663363 "Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell";   Reactome:R-HSA-9855089 "PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients"


show annotations for term's descendants           Sort by:
mechanosensitive monoatomic cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Piezo1 piezo-type mechanosensitive ion channel component 1 enables IEA
ISO		 GO_REF:0000107
(PMID:25955826)
(PMID:32142647)		 Ensembl
RGD		 PMID:25955826 PMID:32142647 GO_REF:0000107 NCBI chr19:67,453,120...67,515,347
Ensembl chr19:50,544,582...50,606,501 		JBrowse link
G Tmem150c transmembrane protein 150C enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:27321926)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:27321926 GO_REF:0000024 GO_REF:0000107 NCBI chr14:9,759,028...9,829,588
Ensembl chr14:9,508,515...9,525,298 		JBrowse link
G Tmem63b transmembrane protein 63B enables ISO (PMID:38127458) RGD PMID:38127458 NCBI chr 9:22,810,753...22,838,163
Ensembl chr 9:15,320,432...15,340,720 		JBrowse link
mechanosensitive potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnk10 potassium two pore domain channel subfamily K member 10 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:38605031)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:38605031 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:123,419,778...123,555,820
Ensembl chr 6:117,694,222...117,825,695 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:38605031)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:38605031 GO_REF:0000024 GO_REF:0000107 NCBI chr13:103,297,387...103,494,686
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kcnk4 potassium two pore domain channel subfamily K member 4 enables IDA
ISO
IEA		 PMID:15677687
(PMID:22282805), (PMID:38605031)
GO_REF:0000107		 RGD
Ensembl		 PMID:22282805 PMID:38605031 PMID:15677687 GO_REF:0000107, RGD:10047327 NCBI chr 1:213,547,577...213,558,706
Ensembl chr 1:204,114,572...204,125,925 		JBrowse link
G Tmem87a transmembrane protein 87A NOT|enables ISO (PMID:36373655) RGD PMID:36373655 NCBI chr 3:107,307,726...107,353,571
Ensembl chr 3:107,307,726...107,353,551 		JBrowse link
stretch-activated, monoatomic cation-selective, calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nalf1 NALCN channel auxiliary factor 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:86,415,540...86,938,150
Ensembl chr16:79,713,724...80,235,120 		JBrowse link
G Nalf2 NALCN channel auxiliary factor 2 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:64,925,100...64,951,074
Ensembl chr  X:64,925,051...64,951,077 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 enables ISO
IEA		 (PMID:23136043)
GO_REF:0000107		 RGD
Ensembl		 PMID:23136043 GO_REF:0000107 NCBI chr12:47,599,161...47,638,143
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21102
    transporter activity 1395
      transmembrane transporter activity 1278
        monoatomic ion transmembrane transporter activity 881
          monoatomic ion channel activity 573
            monoatomic cation channel activity 453
              mechanosensitive monoatomic cation channel activity 10
                mechanosensitive potassium channel activity 4
                mechanosensitive voltage-gated sodium channel activity 0
                stretch-activated, monoatomic cation-selective, calcium channel activity + 3
Path 2
Term Annotations click to browse term
  molecular_function 21102
    transporter activity 1395
      transmembrane transporter activity 1278
        passive transmembrane transporter activity 637
          channel activity 637
            monoatomic ion channel activity 573
              mechanosensitive monoatomic ion channel activity 20
                mechanosensitive monoatomic cation channel activity 10
                  mechanosensitive potassium channel activity 4
                  mechanosensitive voltage-gated sodium channel activity 0
                  stretch-activated, monoatomic cation-selective, calcium channel activity + 3
paths to the root