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ONTOLOGY REPORT - ANNOTATIONS


Term:modulation of excitatory postsynaptic potential
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Accession:GO:0098815 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.



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modulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO
IEA
UniProtKB:P49582 (PMID:20974225)
ComplexPortal:CPX-1134|UniProtKB:P49582 (PMID:19118188)
GO_REF:0000107
RGD
Ensembl
PMID:19118188 PMID:20974225 GO_REF:0000107 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO
IEA
UniProtKB:P05067 (PMID:20974225)
GO_REF:0000107
RGD
Ensembl
PMID:20974225 GO_REF:0000107 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IMP RGD PMID:30206770 RGD:405650589 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 IMP RGD PMID:12597860 RGD:152995391 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 IMP RGD PMID:12597860 RGD:152995391 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IMP RGD PMID:34233182 RGD:401940191 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Pclo piccolo (presynaptic cytomatrix protein) IMP RGD PMID:31074746 RGD:41408338 NCBI chr 4:19,691,439...20,050,015
Ensembl chr 4:19,695,315...20,049,885
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 IMP RGD PMID:22750032 RGD:13463484 NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716
JBrowse link
G Slc8a2 solute carrier family 8 member A2 acts_upstream_of_or_within ISO
IEA
(PMID:29274751)
GO_REF:0000107
RGD
Ensembl
PMID:29274751 GO_REF:0000107 NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072
JBrowse link
G Slc8a3 solute carrier family 8 member A3 acts_upstream_of_or_within ISO
IEA
(PMID:29274751)
GO_REF:0000107
RGD
Ensembl
PMID:29274751 GO_REF:0000107 NCBI chr 6:106,605,611...106,739,208
Ensembl chr 6:100,874,369...101,007,508
JBrowse link
G Stx1a syntaxin 1A involved_in IMP PMID:18703708 ParkinsonsUK-UCL PMID:18703708 RGD:11535099 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Tmem108 transmembrane protein 108 involved_in ISO
IEA
(PMID:28096412)
GO_REF:0000107
RGD
Ensembl
PMID:28096412 GO_REF:0000107 NCBI chr 8:104,066,081...104,360,172
Ensembl chr 8:104,066,078...104,360,094
JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 IMP RGD PMID:24117785 RGD:8554267 NCBI chr 3:154,528,917...154,629,532
Ensembl chr 3:154,529,043...154,628,463
JBrowse link
negative regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbln1 cerebellin 1 precursor involved_in ISO
IEA
(PMID:27418511)
GO_REF:0000107
RGD
Ensembl
PMID:27418511 GO_REF:0000107 NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572
JBrowse link
G Celf4 CUGBP, Elav-like family member 4 acts_upstream_of_or_within ISO
IEA
MGI:5425630 (PMID:21745337)
GO_REF:0000107
RGD
Ensembl
PMID:21745337 GO_REF:0000107 NCBI chr18:16,786,578...17,065,045
Ensembl chr18:16,786,867...17,064,786
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 IMP RGD PMID:17632064 RGD:10044262 NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO
IEA
(PMID:21307259)
GO_REF:0000107
RGD
Ensembl
PMID:21307259 GO_REF:0000107 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Mtmr2 myotubularin related protein 2 involved_in IMP PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172
JBrowse link
G Nlgn3 neuroligin 3 involved_in ISO (PMID:21808020) RGD PMID:21808020 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876
JBrowse link
G Npy2r neuropeptide Y receptor Y2 IDA RGD PMID:12055128 RGD:1642608 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024
JBrowse link
G Plk2 polo-like kinase 2 IMP RGD PMID:20802490 RGD:152995511 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:19033459 RGD:10413844 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:21411674) RGD PMID:21411674 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 acts_upstream_of_or_within ISO MGI:2180817 (PMID:11553273) RGD PMID:11553273 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
JBrowse link
G Tmem25 transmembrane protein 25 involved_in IBA
IEA
ISO
GO_REF:0000033
GO_REF:0000107
(PMID:31424425)
GO_Central
Ensembl
RGD
PMID:31424425 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:45,107,116...45,112,657
Ensembl chr 8:45,107,121...45,116,389
JBrowse link
negative regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syne1 spectrin repeat containing nuclear envelope protein 1 IMP RGD PMID:24191017 RGD:13209020 NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322
JBrowse link
positive regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134|UniProtKB:P49582 (PMID:19118188) RGD PMID:19118188 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 IMP RGD PMID:15758177 RGD:9684984 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IMP RGD PMID:22187436 RGD:13514092 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO
GO_REF:0000107
ComplexPortal:CPX-1134|UniProtKB:P05067-PRO_0000000092 (PMID:19118188)
Ensembl
RGD
PMID:19118188 GO_REF:0000107 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Cux2 cut-like homeobox 2 involved_in ISO (PMID:20510857) RGD PMID:20510857 NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
JBrowse link
G Dbn1 drebrin 1 IMP RGD PMID:19174472 RGD:10398809 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 involved_in IDA
IMP
PMID:12930820 BHF-UCL
CACAO
PMID:12930820 PMID:12930820 RGD:8554754, RGD:8554754 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Drd4 dopamine receptor D4 IMP RGD PMID:21622557 RGD:7248611 NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 involved_in IGI PMID:21670302 ParkinsonsUK-UCL PMID:21670302 RGD:10449514 NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 IMP RGD PMID:23345231 RGD:405100730 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 involved_in IDA
ISS
PMID:12930820
PMID:22246434
PMID:19793963
GO_REF:0000114
ComplexPortal PMID:12930820 PMID:22246434 PMID:19793963 GO_REF:0000114, RGD:8554754, RGD:150521639, RGD:150521643 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A involved_in IDA
ISS
IMP
PMID:12930820
PMID:22246434
GO_REF:0000114
ComplexPortal
RGD
PMID:12930820 PMID:22246434 PMID:29339324 GO_REF:0000114, RGD:8554754, RGD:150521639, RGD:401940161 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B involved_in IDA
ISS
IMP
PMID:19793963
GO_REF:0000114
ComplexPortal
RGD
PMID:19793963 PMID:29339324 GO_REF:0000114, RGD:150521643, RGD:401940161 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C involved_in IDA PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,488,431...100,506,427
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D involved_in IDA PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:96,308,365...96,344,793
JBrowse link
G Grip2 glutamate receptor interacting protein 2 involved_in IMP PMID:20083202 UniProt PMID:20083202 RGD:4107359 NCBI chr 4:125,828,609...125,913,693
Ensembl chr 4:124,271,456...124,321,268
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:28975565 RGD:13506836 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:20007479 RGD:4107027 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Neto1 neuropilin and tolloid like 1 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
GO_REF:0000033
MGI:3836584 (PMID:21734292)
GO_REF:0000107
GO_Central
RGD
Ensembl
PMID:21734292 GO_REF:0000033 GO_REF:0000107 NCBI chr18:79,635,633...79,753,913
Ensembl chr18:79,635,633...79,749,030
JBrowse link
G Neto2 neuropilin and tolloid like 2 NOT|acts_upstream_of_or_within ISO MGI:5141222 (PMID:21734292) RGD PMID:21734292 NCBI chr19:21,344,299...21,415,524
Ensembl chr19:21,344,289...21,417,023
JBrowse link
G Ngfr nerve growth factor receptor IMP RGD PMID:23114219 RGD:10414080 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nlgn1 neuroligin 1 involved_in IDA
ISO
IMP
PMID:17582332
PMID:19730411
UniProtKB:Q99K10 (PMID:23143522)
PMID:19628693
(PMID:17582332), (PMID:23143522)
RGD PMID:17582332 PMID:23143522 PMID:17582332 PMID:19730411 PMID:19628693 RGD:8553502, RGD:8554379, RGD:8554760 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464
JBrowse link
G Nlgn2 neuroligin 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15620359)
BHF-UCL
Ensembl
RGD
PMID:15620359 GO_REF:0000024 GO_REF:0000107 NCBI chr10:54,544,461...54,557,854
Ensembl chr10:54,544,588...54,558,434
JBrowse link
G Nlgn3 neuroligin 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:21642956)
BHF-UCL
RGD
PMID:21642956 GO_REF:0000024 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876
JBrowse link
G Nrxn1 neurexin 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19098102)
(PMID:19822762)
BHF-UCL
Ensembl
RGD
PMID:19098102 PMID:19822762 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IMP RGD PMID:31329835 RGD:597015744 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta IMP RGD PMID:33479380 RGD:150519900 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942
JBrowse link
G Prkcz protein kinase C, zeta involved_in IDA PMID:11914719 UniProt PMID:11914719 RGD:8554098 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:18082964) RGD PMID:18082964 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in IMP PMID:11239437 Alzheimers_University_of_Toronto PMID:11239437 RGD:8553497 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Reln reelin involved_in ISO (PMID:17229826), (PMID:20357114), (PMID:21814183) RGD PMID:17229826 PMID:20357114 PMID:21814183 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rgs4 regulator of G-protein signaling 4 IMP RGD PMID:17220354 RGD:13524537 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISS
ISO
GO_REF:0000024
UniProtKB:Q99NE5|UniProtKB:Q9EQZ7 (PMID:21262469)
ParkinsonsUK-UCL
RGD
PMID:21262469 GO_REF:0000024 NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 involved_in ISS
ISO
GO_REF:0000024
UniProtKB:Q99NE5|UniProtKB:Q9EQZ7 (PMID:21262469)
ParkinsonsUK-UCL
RGD
PMID:21262469 GO_REF:0000024 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:18272690)
GO_REF:0000107
BHF-UCL
RGD
Ensembl
PMID:18272690 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in ISS
IEA
ISO
PMID:21795692
GO_REF:0000107
GO_REF:0000024
(PMID:21167025), (PMID:21423165), (PMID:21795692)
Ensembl
BHF-UCL
RGD
PMID:21167025 PMID:21423165 PMID:21795692 PMID:21795692 GO_REF:0000024 GO_REF:0000107, RGD:7349315 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
JBrowse link
G Ssh1 slingshot protein phosphatase 1 IMP RGD PMID:20442266 RGD:11535133 NCBI chr12:42,621,127...42,683,262
Ensembl chr12:42,621,135...42,683,274
JBrowse link
G Stx1a syntaxin 1A involved_in ISO
IEA
UniProtKB:O35526|UniProtKB:P61264 (PMID:24133272)
GO_REF:0000107
RGD
Ensembl
PMID:24133272 GO_REF:0000107 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Stx1b syntaxin 1B involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
UniProtKB:O35526 (PMID:24133272)
ParkinsonsUK-UCL
Ensembl
RGD
PMID:24133272 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:191,846,016...191,864,878
Ensembl chr 1:182,415,546...182,441,280
JBrowse link
G Tbc1d24 TBC1 domain family, member 24 IMP RGD PMID:24469796 RGD:11537391 NCBI chr10:13,205,819...13,236,013
Ensembl chr10:13,209,895...13,236,050
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:30676422 RGD:597976449 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Wnt7a Wnt family member 7A involved_in ISO
IEA
(PMID:21670302)
UniProtKB:Q9WVB9 (PMID:21670302)
GO_REF:0000107
RGD
Ensembl
PMID:21670302 GO_REF:0000107 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
JBrowse link
positive regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 involved_in IEA
ISO
GO_REF:0000107
ComplexPortal:CPX-1070 (PMID:20395454)
Ensembl
RGD
PMID:20395454 GO_REF:0000107 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Afdn afadin, adherens junction formation factor IMP RGD PMID:22948147 RGD:13838731 NCBI chr 1:53,905,344...54,034,216
Ensembl chr 1:53,905,373...54,034,216
JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 involved_in IMP PMID:26595655 UniProt PMID:26595655 RGD:11085699 NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348
JBrowse link
regulation of acetylcholine-gated cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit IMP RGD PMID:11904236 RGD:704387 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmpk DM1 protein kinase acts_upstream_of_or_within ISO
IEA
MGI:2182402 (PMID:11526199)
GO_REF:0000107
RGD
Ensembl
PMID:11526199 GO_REF:0000107 NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    regulation of biological process 13394
      regulation of signaling 3874
        regulation of signal transduction 3310
          modulation of excitatory postsynaptic potential 67
            negative regulation of excitatory postsynaptic potential + 13
            positive regulation of excitatory postsynaptic potential + 45
            regulation of acetylcholine-gated cation channel activity 1
            regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
            regulation of mini excitatory postsynaptic potential + 4
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          cell-cell signaling 1487
            synaptic signaling 1008
              trans-synaptic signaling 964
                anterograde trans-synaptic signaling 956
                  chemical synaptic transmission 956
                    chemical synaptic transmission, postsynaptic 140
                      excitatory postsynaptic potential 126
                        modulation of excitatory postsynaptic potential 67
                          negative regulation of excitatory postsynaptic potential + 13
                          positive regulation of excitatory postsynaptic potential + 45
                          regulation of acetylcholine-gated cation channel activity 1
                          regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
                          regulation of mini excitatory postsynaptic potential + 4
paths to the root