ONTOLOGY REPORT - ANNOTATIONS
Term: ligand-modulated transcription factor activity
Accession: GO:0098531
browse the term
Definition: A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.
Comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
Synonyms: exact_synonym: direct ligand regulated sequence-specific DNA binding transcription factor activity
narrow_synonym: ligand-activated transcription factor activity
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Bach1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
enables
ISO IEA
GO_Central Ensembl
GO_REF:0000107 GO_REF:0000119
NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234
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Rora
RAR-related orphan receptor alpha
enables
ISO ISS
GO_Central UniProt
GO_REF:0000024 GO_REF:0000119
NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528
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Rorc
RAR-related orphan receptor gamma
enables
ISO
GO_Central
GO_REF:0000119
NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
enables
IMP
(PMID:21757002)
BHF-UCL
PMID:21757002
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
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Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
enables
ISO IEA
GO_Central Ensembl
GO_REF:0000107 GO_REF:0000119
NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
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Esr1
estrogen receptor 1 (alpha)
enables
ISO IEA
GO_Central Ensembl
GO_REF:0000107 GO_REF:0000119
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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Esr2
estrogen receptor 2 (beta)
enables
ISO IEA
GO_Central InterPro
GO_REF:0000002 GO_REF:0000119
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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Gper1
G protein-coupled estrogen receptor 1
enables
ISO IBA IDA
(PMID:23545157)
GO_Central UniProt
PMID:23545157
GO_REF:0000033 GO_REF:0000119
NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555
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Pde3a
phosphodiesterase 3A, cGMP inhibited
enables
IEA ISO
Ensembl GO_Central
GO_REF:0000107 GO_REF:0000119
NCBI chr 6:141,194,995...141,452,588
Ensembl chr 6:141,194,995...141,453,174
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
enables
IDA
(PMID:15199138), (PMID:7914432), (PMID:9237103)
MGI
PMID:7914432 PMID:9237103 PMID:15199138
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Ahr
aryl-hydrocarbon receptor
enables contributes_to
ISO IDA
(PMID:1314586), (PMID:33436590)
GO_Central UniProt
PMID:1314586 PMID:33436590
GO_REF:0000096 GO_REF:0000119
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
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Ahrr
aryl-hydrocarbon receptor repressor
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr13:74,359,237...74,440,450
Ensembl chr13:74,359,237...74,440,450
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Ar
androgen receptor
NOT|enables
ISO ISS IDA IBA
(PMID:19244107) (PMID:12145204), (PMID:15199138), (PMID:18761815), (PMID:23786676)
UniProt RGD UniProt MGI GO_Central
PMID:2341409 PMID:12145204 PMID:15199138 PMID:18761815 PMID:19244107 PMID:23786676 More...
GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1298681
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
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Arnt
aryl hydrocarbon receptor nuclear translocator
contributes_to
IMP ISS ISO
(PMID:11043581)
MGI UniProt GO_Central
PMID:11043581
GO_REF:0000024 GO_REF:0000119
NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551
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Esr1
estrogen receptor 1 (alpha)
enables
IDA IBA ISO
(PMID:15322135)
MGI GO_Central
PMID:15322135
GO_REF:0000008 GO_REF:0000033 GO_REF:0000119
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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Esr2
estrogen receptor 2 (beta)
enables
ISO IBA
GO_Central
GO_REF:0000033 GO_REF:0000119
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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Esrra
estrogen related receptor, alpha
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208
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Esrrb
estrogen related receptor, beta
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr12:86,407,891...86,568,402
Ensembl chr12:86,407,891...86,568,402
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Esrrg
estrogen-related receptor gamma
enables
NAS IBA
(PMID:10072763)
UniProt GO_Central
PMID:10072763
GO_REF:0000033
NCBI chr 1:187,340,707...187,947,082
Ensembl chr 1:187,340,988...187,947,082
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Hnf4a
hepatic nuclear factor 4, alpha
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830
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Hnf4g
hepatocyte nuclear factor 4, gamma
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 3:3,573,090...3,724,863
Ensembl chr 3:3,573,084...3,724,860
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Nkx3-1
NK3 homeobox 1
enables
ISO ISS
GO_Central UniProt
GO_REF:0000024 GO_REF:0000119
NCBI chr14:69,428,141...69,432,107
Ensembl chr14:69,428,087...69,432,111
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159
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Nr1d2
nuclear receptor subfamily 1, group D, member 2
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:4,230,549...4,265,639
Ensembl chr14:4,230,569...4,265,642
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Nr1h2
nuclear receptor subfamily 1, group H, member 2
enables
IDA IBA
(PMID:14739254)
MGI GO_Central
PMID:14739254
GO_REF:0000033
NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
enables contributes_to
IDA ISS
(PMID:14739254) (PMID:17107947)
MGI UniProt BHF-UCL
PMID:14739254 PMID:17107947
GO_REF:0000024
NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
enables
IDA IBA ISO
(PMID:27471003)
MGI GO_Central
PMID:27471003
GO_REF:0000033 GO_REF:0000096 GO_REF:0000119
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
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Nr1h5
nuclear receptor subfamily 1, group H, member 5
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 3:102,846,974...102,871,607
Ensembl chr 3:102,846,974...102,871,449
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
enables
ISO IBA ISS
RGD GO_Central UniProt
PMID:10967130
GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:61490
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
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Nr2c1
nuclear receptor subfamily 2, group C, member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr10:93,983,491...94,033,078
Ensembl chr10:93,983,885...94,033,073
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Nr2c2
nuclear receptor subfamily 2, group C, member 2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 6:92,068,426...92,150,039
Ensembl chr 6:92,068,371...92,151,275
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Nr2e1
nuclear receptor subfamily 2, group E, member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr10:42,437,959...42,459,721
Ensembl chr10:42,437,959...42,459,628
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Nr2e3
nuclear receptor subfamily 2, group E, member 3
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 9:59,850,054...59,868,117
Ensembl chr 9:59,850,054...59,867,942
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Nr2f1
nuclear receptor subfamily 2, group F, member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr13:78,337,090...78,346,954
Ensembl chr13:78,337,092...78,347,876
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Nr2f2
nuclear receptor subfamily 2, group F, member 2
enables
ISO IBA ISS
GO_Central UniProt
GO_REF:0000024 GO_REF:0000033 GO_REF:0000119
NCBI chr 7:70,001,694...70,016,494
Ensembl chr 7:70,001,692...70,016,483
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Nr2f6
nuclear receptor subfamily 2, group F, member 6
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 8:71,826,762...71,834,593
Ensembl chr 8:71,826,767...71,834,604
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
enables
ISS IBA ISO
UniProt GO_Central
GO_REF:0000024 GO_REF:0000033 GO_REF:0000119
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
enables
IEA
InterPro
GO_REF:0000002
NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
enables
TAS
(PMID:9092472)
MGI
PMID:9092472
NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447
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Nr5a1
nuclear receptor subfamily 5, group A, member 1
enables
ISO IEA
GO_Central Ensembl
GO_REF:0000107 GO_REF:0000119
NCBI chr 2:38,582,668...38,604,554
Ensembl chr 2:38,582,668...38,604,554
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Nr5a2
nuclear receptor subfamily 5, group A, member 2
enables
ISO IEA
RGD GO_Central Ensembl
PMID:8668203
GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 RGD:68248
NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186
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Nr6a1
nuclear receptor subfamily 6, group A, member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 2:38,613,381...38,816,464
Ensembl chr 2:38,613,382...38,817,700
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Pgr
progesterone receptor
enables
IMP IBA
(PMID:14681235)
MGI GO_Central
PMID:14681235
GO_REF:0000033
NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
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Ppara
peroxisome proliferator activated receptor alpha
enables
ISO IBA IDA
(PMID:29331071)
RGD GO_Central UniProt
PMID:12189208 PMID:12966092 PMID:29331071
GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1580224 RGD:729665
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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Ppard
peroxisome proliferator activator receptor delta
enables
TAS IBA ISO ISS
(PMID:10866668)
MGI GO_Central UniProt
PMID:10866668
GO_REF:0000024 GO_REF:0000033 GO_REF:0000119
NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448
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Pparg
peroxisome proliferator activated receptor gamma
enables
TAS IBA IDA ISO
(PMID:12163159) (PMID:16239304), (PMID:35710596)
MGI GO_Central UniProt
PMID:12163159 PMID:16239304 PMID:35710596
GO_REF:0000033 GO_REF:0000119
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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Rara
retinoic acid receptor, alpha
enables
IDA IBA ISO
(PMID:15322135), (PMID:15528198)
MGI GO_Central
PMID:15322135 PMID:15528198
GO_REF:0000033 GO_REF:0000119
NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768
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Rarb
retinoic acid receptor, beta
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924
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Rarg
retinoic acid receptor, gamma
enables
ISO IBA IEA
RGD GO_Central Ensembl
PMID:11072095
GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 RGD:1300463
NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952
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Rora
RAR-related orphan receptor alpha
enables
IBA IEA
GO_Central InterPro
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528
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Rorb
RAR-related orphan receptor beta
enables
IBA IEA
GO_Central InterPro
GO_REF:0000002 GO_REF:0000033
NCBI chr19:18,907,966...19,088,560
Ensembl chr19:18,907,969...19,088,560
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Rorc
RAR-related orphan receptor gamma
enables
IBA IEA
GO_Central InterPro
GO_REF:0000002 GO_REF:0000033
NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583
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Rxra
retinoid X receptor alpha
enables contributes_to
IDA ISO
(PMID:1312497), (PMID:15322135) (PMID:17107947)
MGI GO_Central BHF-UCL
PMID:1312497 PMID:15322135 PMID:17107947
GO_REF:0000119
NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
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Rxrb
retinoid X receptor beta
enables
ISO IBA
RGD GO_Central
PMID:1662118
GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:729677
NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373
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Rxrg
retinoid X receptor gamma
enables
IDA IBA
(PMID:1312497)
MGI GO_Central
PMID:1312497
GO_REF:0000033
NCBI chr 1:167,425,902...167,467,191
Ensembl chr 1:167,425,953...167,467,192
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Srebf1
sterol regulatory element binding transcription factor 1
enables
IEA ISO
Ensembl GO_Central
GO_REF:0000107 GO_REF:0000119
NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
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Stat3
signal transducer and activator of transcription 3
enables
IEA ISO
Ensembl GO_Central
GO_REF:0000107 GO_REF:0000119
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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Thra
thyroid hormone receptor alpha
enables
IDA IBA ISO ISS TAS
(PMID:15322135) (PMID:9250685)
MGI GO_Central UniProt
PMID:9250685 PMID:15322135
GO_REF:0000024 GO_REF:0000033 GO_REF:0000119
NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832
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Thrb
thyroid hormone receptor beta
enables
ISO IBA ISS IMP TAS
(PMID:20203194) (PMID:10430610), (PMID:8673137), (PMID:9275045), (PMID:9832432), (PMID:9927422)
RGD GO_Central UniProt MGI
PMID:2457590 PMID:8673137 PMID:9275045 PMID:9832432 PMID:9927422 PMID:10430610 PMID:20203194 More...
GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:729962
NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435
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Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
enables
ISO IBA ISS IDA
(PMID:15322135)
RGD GO_Central UniProt MGI
PMID:9579411 PMID:15322135
GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:70308
NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
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Abhd2
abhydrolase domain containing 2
enables
ISS ISO
UniProt GO_Central
GO_REF:0000024 GO_REF:0000119
NCBI chr 7:78,923,002...79,015,257
Ensembl chr 7:78,922,947...79,015,256
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Esr1
estrogen receptor 1 (alpha)
enables
ISO
17-beta-estradiol (E2)
RGD GO_Central
PMID:17928626
GO_REF:0000096 RGD:5128669
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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Esr2
estrogen receptor 2 (beta)
enables
ISO
17-beta-estradiol (E2)
RGD GO_Central
PMID:17928626
GO_REF:0000096 RGD:5128669
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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Esrra
estrogen related receptor, alpha
enables
IEA
InterPro
GO_REF:0000002
NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208
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Esrrb
estrogen related receptor, beta
enables
IEA
InterPro
GO_REF:0000002
NCBI chr12:86,407,891...86,568,402
Ensembl chr12:86,407,891...86,568,402
G
Esrrg
estrogen-related receptor gamma
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 1:187,340,707...187,947,082
Ensembl chr 1:187,340,988...187,947,082
G
Nr3c2
nuclear receptor subfamily 3, group C, member 2
enables
ISO
RGD GO_Central
PMID:17260968
GO_REF:0000096 RGD:1600931
NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641
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Or51e2
olfactory receptor family 51 subfamily E member 2
enables
ISS ISO
UniProt GO_Central
GO_REF:0000024 GO_REF:0000119
NCBI chr 7:102,389,928...102,408,678
Ensembl chr 7:102,387,718...102,408,678
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Paqr7
progestin and adipoQ receptor family member VII
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 4:134,224,315...134,237,548
Ensembl chr 4:134,224,008...134,237,546
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Paqr8
progestin and adipoQ receptor family member VIII
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 1:20,960,772...21,009,874
Ensembl chr 1:20,960,830...21,009,874
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Pgr
progesterone receptor
enables
ISO IDA
(PMID:16176985)
RGD GO_Central MGI
PMID:11113338 PMID:16176985
GO_REF:0000096 RGD:1601290
NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
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Ppara
peroxisome proliferator activated receptor alpha
enables
TAS ISO
(PMID:10377439)
MGI GO_Central
PMID:10377439
GO_REF:0000119
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
G
Rxra
retinoid X receptor alpha
enables
IEA
InterPro UniProt
GO_REF:0000002 GO_REF:0000104
NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969
G
Rxrb
retinoid X receptor beta
enables
IEA
InterPro
GO_REF:0000002
NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373
G
Rxrg
retinoid X receptor gamma
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 1:167,425,902...167,467,191
Ensembl chr 1:167,425,953...167,467,192
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Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
enables
ISO
(PMID:10678179), (PMID:12016314), (PMID:17082781)
UniProt
PMID:10678179 PMID:12016314 PMID:17082781
NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
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