ONTOLOGY REPORT - ANNOTATIONS
Term: ligand-modulated transcription factor activity
Accession: GO:0098531
browse the term
Definition: A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.
Comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
Synonyms: exact_synonym: direct ligand regulated sequence-specific DNA binding transcription factor activity
narrow_synonym: ligand-activated transcription factor activity
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BACH1
BTB domain and CNC homolog 1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr31:24,269,310...24,310,369
Ensembl chr31:24,269,280...24,381,454
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RORA
RAR related orphan receptor A
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr30:25,315,974...26,026,708
Ensembl chr30:25,325,275...26,026,623
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RORC
RAR related orphan receptor C
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr17:60,821,498...60,842,485
Ensembl chr17:60,821,981...60,842,453
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NR1H4
nuclear receptor subfamily 1 group H member 4
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr15:39,497,313...39,608,120
Ensembl chr15:39,536,290...39,608,116
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VDR
vitamin D receptor
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470
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ESR1
estrogen receptor 1
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
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ESR2
estrogen receptor 2
enables
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691
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GPER1
G protein-coupled estrogen receptor 1
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 6:15,792,072...15,796,922
Ensembl chr 6:15,792,897...15,794,051
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PDE3A
phosphodiesterase 3A
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr27:26,555,558...26,878,624
Ensembl chr27:26,560,547...26,878,913
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NR3C1
nuclear receptor subfamily 3 group C member 1
enables
IEA
InterPro Ensembl
GO_REF:0000002 GO_REF:0000107
NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755
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AHR
aryl hydrocarbon receptor
contributes_to enables
ISO IBA IEA
(PMID:34521881)
UniProt GO_Central UniProt Ensembl
PMID:34521881
GO_REF:0000033 GO_REF:0000107 GO_REF:0000117
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
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AHRR
aryl hydrocarbon receptor repressor
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr34:11,820,119...11,865,681
Ensembl chr34:11,820,473...11,867,821
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AR
androgen receptor
NOT|enables
ISO IBA IEA ISS
(PMID:19244107)
UniProt GO_Central Ensembl InterPro BHF-UCL RGD
PMID:2341409 PMID:19244107
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:1298681
NCBI chr24:34,713,390...34,731,461 NCBI chr X:51,969,785...52,167,450
Ensembl chr X:51,969,785...52,151,912
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ARNT
aryl hydrocarbon receptor nuclear translocator
enables contributes_to
IEA ISO
(PMID:11043581) (PMID:34521881)
Ensembl MGI UniProt
PMID:11043581 PMID:34521881
GO_REF:0000107
Ensembl chr17:59,941,353...60,010,867 Ensembl chr17:59,941,353...60,010,867
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ESR1
estrogen receptor 1
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
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ESR2
estrogen receptor 2
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691
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ESRRA
estrogen related receptor alpha
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr18:52,755,547...52,762,938
Ensembl chr18:52,756,344...52,763,355
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ESRRB
estrogen related receptor beta
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 8:49,253,877...49,424,148
Ensembl chr 8:49,253,332...49,421,332
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ESRRG
estrogen related receptor gamma
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr38:11,825,055...12,439,143
Ensembl chr38:11,823,520...12,256,028
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HNF4A
hepatocyte nuclear factor 4 alpha
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr24:31,847,864...31,908,337
Ensembl chr24:31,847,961...31,905,916
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HNF4G
hepatocyte nuclear factor 4 gamma
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr29:23,683,380...23,801,799
Ensembl chr29:23,732,339...23,801,519
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LOC607038
bile acid receptor-like
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr17:52,517,654...52,537,209
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NKX3-1
NK3 homeobox 1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr25:33,815,343...33,817,465
Ensembl chr25:33,815,095...33,817,474
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NR1D1
nuclear receptor subfamily 1 group D member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 9:22,461,556...22,469,243
Ensembl chr 9:22,461,705...22,469,053
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NR1D2
nuclear receptor subfamily 1 group D member 2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr23:19,758,907...19,787,725
Ensembl chr23:19,762,052...19,787,614
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NR1H2
nuclear receptor subfamily 1 group H member 2
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 1:106,332,691...106,339,168
Ensembl chr 1:106,332,798...106,339,135
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NR1H3
nuclear receptor subfamily 1 group H member 3
enables contributes_to
IEA IBA ISO
(PMID:17107947)
InterPro GO_Central BHF-UCL Ensembl
PMID:17107947
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr18:42,333,173...42,346,152
Ensembl chr18:42,333,202...42,341,236
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NR1H4
nuclear receptor subfamily 1 group H member 4
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr15:39,497,313...39,608,120
Ensembl chr15:39,536,290...39,608,116
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NR1I2
nuclear receptor subfamily 1 group I member 2
enables
ISO IBA IEA
RGD GO_Central Ensembl
PMID:10967130
GO_REF:0000033 GO_REF:0000107 RGD:61490
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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NR1I3
nuclear receptor subfamily 1 group I member 3
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
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NR2C1
nuclear receptor subfamily 2 group C member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr15:35,003,658...35,049,812
Ensembl chr15:35,005,066...35,038,968
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NR2C2
nuclear receptor subfamily 2 group C member 2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr20:5,041,656...5,139,859
Ensembl chr20:5,052,232...5,133,721
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NR2E1
nuclear receptor subfamily 2 group E member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr12:65,209,177...65,230,274
Ensembl chr12:65,209,542...65,228,998
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NR2E3
nuclear receptor subfamily 2 group E member 3
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr30:35,375,181...35,382,398
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NR2F1
nuclear receptor subfamily 2 group F member 1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 3:15,707,198...15,716,875
Ensembl chr 3:15,707,640...15,716,875
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NR2F2
nuclear receptor subfamily 2 group F member 2
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 3:44,135,143...44,148,836
Ensembl chr 3:44,136,463...44,148,524
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NR2F6
nuclear receptor subfamily 2 group F member 6
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr20:45,490,113...45,500,606
Ensembl chr20:45,464,356...45,500,608
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NR3C1
nuclear receptor subfamily 3 group C member 1
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755
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NR3C2
nuclear receptor subfamily 3 group C member 2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr15:46,390,030...46,718,000
Ensembl chr15:46,390,023...46,710,131
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NR4A1
nuclear receptor subfamily 4 group A member 1
enables
IEA
InterPro
GO_REF:0000002
NCBI chr27:2,947,729...2,965,045
Ensembl chr27:2,891,053...2,955,655
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NR4A2
nuclear receptor subfamily 4 group A member 2
enables
IEA
InterPro
GO_REF:0000002
NCBI chr36:2,546,237...2,554,559
Ensembl chr36:2,547,421...2,552,780
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NR4A3
nuclear receptor subfamily 4 group A member 3
enables
IEA
InterPro
GO_REF:0000002
NCBI chr11:56,806,506...56,846,997
Ensembl chr11:56,812,804...56,847,689
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NR5A1
nuclear receptor subfamily 5 group A member 1
enables
IEA
InterPro Ensembl
GO_REF:0000002 GO_REF:0000107
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NR5A2
nuclear receptor subfamily 5 group A member 2
enables
ISO IEA
RGD Ensembl InterPro
PMID:8668203
GO_REF:0000002 GO_REF:0000107 RGD:68248
NCBI chr 7:2,925,915...3,062,118
Ensembl chr 7:2,927,326...3,062,348
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NR6A1
nuclear receptor subfamily 6 group A member 1
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 9:58,385,981...58,485,003
Ensembl chr 9:58,266,726...58,446,000 Ensembl chr 9:58,266,726...58,446,000
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PGR
progesterone receptor
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511
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PPARA
peroxisome proliferator activated receptor alpha
enables
ISO IBA ISS IEA
RGD GO_Central UniProt InterPro
PMID:12189208 PMID:12966092
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 RGD:1580224 RGD:729665
NCBI chr10:19,934,020...20,006,096
Ensembl chr10:19,934,165...20,006,146
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PPARD
peroxisome proliferator activated receptor delta
enables
ISS IBA IEA
UniProt GO_Central Ensembl InterPro
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr12:4,492,867...4,579,340
Ensembl chr12:4,492,672...4,579,340
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PPARG
peroxisome proliferator activated receptor gamma
enables
ISS IBA IEA
UniProt GO_Central InterPro
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033
NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981
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RARA
retinoic acid receptor alpha
enables
IEA IBA
Ensembl GO_Central InterPro
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459
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RARB
retinoic acid receptor beta
enables
IEA
InterPro
GO_REF:0000002
NCBI chr23:18,207,253...18,931,128
Ensembl chr23:18,207,760...18,482,652
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RARG
retinoic acid receptor gamma
enables
ISO IEA
RGD InterPro
PMID:11072095
GO_REF:0000002 RGD:1300463
NCBI chr27:1,958,432...1,978,471
Ensembl chr27:1,958,204...1,978,476
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RORA
RAR related orphan receptor A
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr30:25,315,974...26,026,708
Ensembl chr30:25,325,275...26,026,623
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RORB
RAR related orphan receptor B
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 1:83,470,569...83,666,200
Ensembl chr 1:83,476,816...83,666,061
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RORC
RAR related orphan receptor C
enables
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr17:60,821,498...60,842,485
Ensembl chr17:60,821,981...60,842,453
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RXRA
retinoid X receptor alpha
enables contributes_to
IEA IBA ISO
(PMID:17107947)
Ensembl GO_Central BHF-UCL
PMID:17107947
GO_REF:0000033 GO_REF:0000107
NCBI chr 9:50,525,195...50,575,720
Ensembl chr 9:50,484,567...50,573,119
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RXRB
retinoid X receptor beta
enables
ISO IBA IEA
RGD GO_Central Ensembl
PMID:1662118
GO_REF:0000033 GO_REF:0000107 RGD:729677
NCBI chr12:2,657,058...2,663,648
Ensembl chr12:2,657,792...2,663,706
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RXRG
retinoid X receptor gamma
enables
IEA IBA
Ensembl GO_Central
GO_REF:0000033 GO_REF:0000107
NCBI chr38:17,867,123...17,912,328
Ensembl chr38:17,867,182...17,920,085
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SF1
splicing factor 1
enables
IEA
InterPro
GO_REF:0000002
NCBI chr18:52,380,058...52,393,833
Ensembl chr18:52,380,211...52,393,048
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SREBF1
sterol regulatory element binding transcription factor 1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:41,663,809...41,686,764
Ensembl chr 5:41,663,773...41,686,776
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STAT3
signal transducer and activator of transcription 3
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672
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THRA
thyroid hormone receptor alpha
enables
IEA IBA
InterPro GO_Central Ensembl
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 9:22,469,466...22,493,445
Ensembl chr 9:22,468,594...22,493,445
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THRB
thyroid hormone receptor beta
enables
ISO IBA IEA
RGD GO_Central Ensembl InterPro
PMID:2457590
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:729962
NCBI chr23:19,278,650...19,648,547
Ensembl chr23:19,277,493...19,660,283
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TSEN2
tRNA splicing endonuclease subunit 2
enables
IEA
InterPro
GO_REF:0000002
NCBI chr20:6,031,295...6,090,938
Ensembl chr20:6,050,357...6,207,981
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VDR
vitamin D receptor
enables
ISO IBA IEA
RGD GO_Central Ensembl InterPro
PMID:9579411
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:70308
NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470
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ABHD2
abhydrolase domain containing 2, acylglycerol lipase
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:52,151,500...52,255,024
Ensembl chr 3:52,151,535...52,249,612
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ESR1
estrogen receptor 1
ISO
17-beta-estradiol (E2)
RGD
PMID:17928626
RGD:5128669
NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
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ESR2
estrogen receptor 2
enables
ISO IEA
17-beta-estradiol (E2)
RGD InterPro
PMID:17928626
GO_REF:0000002 RGD:5128669
NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691
G
ESRRA
estrogen related receptor alpha
enables
IEA
InterPro
GO_REF:0000002
NCBI chr18:52,755,547...52,762,938
Ensembl chr18:52,756,344...52,763,355
G
ESRRB
estrogen related receptor beta
enables
IEA
InterPro
GO_REF:0000002
NCBI chr 8:49,253,877...49,424,148
Ensembl chr 8:49,253,332...49,421,332
G
ESRRG
estrogen related receptor gamma
enables
IEA
InterPro
GO_REF:0000002
NCBI chr38:11,825,055...12,439,143
Ensembl chr38:11,823,520...12,256,028
G
HNF4A
hepatocyte nuclear factor 4 alpha
enables
IEA
InterPro
GO_REF:0000002
NCBI chr24:31,847,864...31,908,337
Ensembl chr24:31,847,961...31,905,916
G
HNF4G
hepatocyte nuclear factor 4 gamma
enables
IEA
InterPro
GO_REF:0000002
NCBI chr29:23,683,380...23,801,799
Ensembl chr29:23,732,339...23,801,519
G
NR3C2
nuclear receptor subfamily 3 group C member 2
ISO
RGD
PMID:17260968
RGD:1600931
NCBI chr15:46,390,030...46,718,000
Ensembl chr15:46,390,023...46,710,131
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OR51E2
olfactory receptor family 51 subfamily E member 2
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr21:27,078,888...27,081,746
Ensembl chr21:27,080,476...27,081,438
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OR51F23
olfactory receptor family 51 subfamily F member 23
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr21:27,089,071...27,090,339
Ensembl chr21:27,089,139...27,090,068
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PAQR7
progestin and adipoQ receptor family member 7
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 2:74,084,915...74,095,633
Ensembl chr 2:74,093,089...74,094,625
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PAQR8
progestin and adipoQ receptor family member 8
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr12:19,968,950...20,059,344
Ensembl chr12:20,020,016...20,056,008
G
PGR
progesterone receptor
enables
ISO IEA
RGD Ensembl InterPro UniProt
PMID:11113338
GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 RGD:1601290
NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511
G
PPARA
peroxisome proliferator activated receptor alpha
enables
ISO
(PMID:19955185)
BHF-UCL
PMID:19955185
NCBI chr10:19,934,020...20,006,096
Ensembl chr10:19,934,165...20,006,146
G
R3HDML
R3H domain containing like
enables
IEA
InterPro
GO_REF:0000002
NCBI chr24:31,829,484...31,839,355
Ensembl chr24:31,830,246...31,839,336
G
RXRA
retinoid X receptor alpha
enables
IEA
InterPro UniProt
GO_REF:0000002 GO_REF:0000104
NCBI chr 9:50,525,195...50,575,720
Ensembl chr 9:50,484,567...50,573,119
G
RXRB
retinoid X receptor beta
enables
IEA
InterPro
GO_REF:0000002
NCBI chr12:2,657,058...2,663,648
Ensembl chr12:2,657,792...2,663,706
G
RXRG
retinoid X receptor gamma
enables
IEA
InterPro UniProt
GO_REF:0000002 GO_REF:0000104
NCBI chr38:17,867,123...17,912,328
Ensembl chr38:17,867,182...17,920,085
G
VDR
vitamin D receptor
enables
ISO
(PMID:10678179), (PMID:12016314), (PMID:17082781)
UniProt
PMID:10678179 PMID:12016314 PMID:17082781
NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all