ONTOLOGY REPORT - ANNOTATIONS
Term: ligand-modulated transcription factor activity
Accession: GO:0098531
browse the term
Definition: A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.
Comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
Synonyms: exact_synonym: direct ligand regulated sequence-specific DNA binding transcription factor activity
narrow_synonym: ligand-activated transcription factor activity
GViewer not supported for the selected species.
G
Bach1
BTB domain and CNC homolog 1
enables
ISO
(PMID:21555518)
UniProt
PMID:21555518
NCBI chrNW_004955407:28,678,181...28,701,115
Ensembl chrNW_004955407:28,678,181...28,701,399
G
Rora
RAR related orphan receptor A
enables
ISO
(PMID:19965867)
UniProt
PMID:19965867
NCBI chrNW_004955450:14,262,199...14,434,611
Ensembl chrNW_004955450:14,262,190...14,425,233
G
Rorc
RAR related orphan receptor C
enables
ISO
(PMID:19965867)
UniProt
PMID:19965867
NCBI chrNW_004955589:590,653...616,784
Ensembl chrNW_004955589:590,743...616,694
G
Nr1h4
nuclear receptor subfamily 1 group H member 4
enables
ISO
PMID:12718893 (PMID:21757002) PMID:10334992 (PMID:10334992), (PMID:21757002), (PMID:23767959)
UniProt BHF-UCL ParkinsonsUK-UCL
PMID:10334992 PMID:12718893 PMID:21757002 PMID:23767959
RGD:15090836 RGD:1625198
NCBI chrNW_004955405:36,160,360...36,236,258
Ensembl chrNW_004955405:36,160,049...36,237,751
G
Vdr
vitamin D receptor
enables
ISO
(PMID:12016314), (PMID:32354638)
UniProt
PMID:12016314 PMID:32354638
NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
G
Esr1
estrogen receptor 1
enables
ISO
(PMID:15831516), (PMID:9338790), (PMID:9841876)
CAFA
PMID:9338790 PMID:9841876 PMID:15831516
NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
G
Esr2
estrogen receptor 2
enables
ISO
(PMID:19126643), (PMID:24033289) (PMID:29261182), (PMID:30113650)
ParkinsonsUK-UCL UniProt
PMID:19126643 PMID:24033289 PMID:29261182 PMID:30113650
NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
G
Gper1
G protein-coupled estrogen receptor 1
enables
ISO
(PMID:23545157) (PMID:15539556), (PMID:15705806)
UniProt
PMID:15539556 PMID:15705806 PMID:23545157
NCBI chrNW_004955460:8,790,798...8,794,902
Ensembl chrNW_004955460:8,790,798...8,794,902
G
Pde3a
phosphodiesterase 3A
enables
ISO
(PMID:31420216), (PMID:35104454)
UniProt
PMID:31420216 PMID:35104454
NCBI chrNW_004955413:16,340,827...16,642,731
Ensembl chrNW_004955413:16,340,918...16,643,214
G
Nr3c1
nuclear receptor subfamily 3 group C member 1
enables
ISO
(PMID:15199138), (PMID:7914432), (PMID:9237103)
MGI
PMID:7914432 PMID:9237103 PMID:15199138
NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221
G
Ahr
aryl hydrocarbon receptor
enables contributes_to
ISO
PMID:7812217 (PMID:1314586), (PMID:33436590) (PMID:10395741), (PMID:28602820), (PMID:32818467), (PMID:32866000) (PMID:34521881)
UniProt
PMID:1314586 PMID:7812217 PMID:10395741 PMID:28602820 PMID:32818467 PMID:32866000 PMID:33436590 PMID:34521881 More...
RGD:8553947
NCBI chrNW_004955410:20,428,531...20,459,482
Ensembl chrNW_004955410:20,428,546...20,456,836
G
Ar
androgen receptor
enables NOT|enables
ISO
(PMID:12799378), (PMID:17277772), (PMID:19886863), (PMID:20048160), (PMID:25091737) (PMID:12145204), (PMID:15199138), (PMID:18761815), (PMID:23786676) (PMID:19345326) (PMID:19244107)
BHF-UCL MGI UniProt RGD
PMID:2341409 PMID:12145204 PMID:12799378 PMID:15199138 PMID:17277772 PMID:18761815 PMID:19244107 PMID:19345326 PMID:19886863 PMID:20048160 PMID:23786676 PMID:25091737 More...
RGD:1298681
NCBI chrNW_004955475:7,013,960...7,192,473
Ensembl chrNW_004955475:7,013,960...7,186,069
G
Arnt
aryl hydrocarbon receptor nuclear translocator
contributes_to
ISO
(PMID:34521881) (PMID:11043581)
UniProt MGI
PMID:11043581 PMID:34521881
NCBI chrNW_004955588:159,462...233,047
Ensembl chrNW_004955588:159,462...233,047
G
Esr1
estrogen receptor 1
enables
ISO
(PMID:18722177) (PMID:15831516) (PMID:15322135)
MGI BHF-UCL
PMID:15322135 PMID:15831516 PMID:18722177
NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
G
Esr2
estrogen receptor 2
enables
ISO
(PMID:19126643)
ParkinsonsUK-UCL
PMID:19126643
NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
G
Hnf4a
hepatocyte nuclear factor 4 alpha
enables
ISO
(PMID:12193589)
GO_Central
PMID:12193589
NCBI chrNW_004955445:12,925,248...12,962,501
Ensembl chrNW_004955445:12,924,662...12,984,281
G
Nkx3-1
NK3 homeobox 1
enables
ISO
(PMID:19886863)
UniProt
PMID:19886863
NCBI chrNW_004955403:46,807,846...46,809,924
Ensembl chrNW_004955403:46,806,178...46,836,310
G
Nr1h2
nuclear receptor subfamily 1 group H member 2
enables
ISO
(PMID:14739254)
MGI
PMID:14739254
NCBI chrNW_004955559:731,630...736,973
Ensembl chrNW_004955559:730,670...737,505
G
Nr1h3
nuclear receptor subfamily 1 group H member 3
enables contributes_to
ISO
(PMID:19481530) (PMID:14739254) (PMID:17107947)
GO_Central MGI BHF-UCL
PMID:14739254 PMID:17107947 PMID:19481530
NCBI chrNW_004955422:940,310...954,170
Ensembl chrNW_004955422:940,310...949,049
G
Nr1h4
nuclear receptor subfamily 1 group H member 4
enables
ISO
(PMID:27471003) PMID:10334992
MGI UniProt
PMID:10334992 PMID:27471003
RGD:15090836
NCBI chrNW_004955405:36,160,360...36,236,258
Ensembl chrNW_004955405:36,160,049...36,237,751
G
Nr1i2
nuclear receptor subfamily 1 group I member 2
enables
ISO
(PMID:12578355)
UniProt RGD
PMID:10967130 PMID:12578355
RGD:61490
NCBI chrNW_004955427:19,459,936...19,487,276
Ensembl chrNW_004955427:19,459,936...19,487,276
G
Nr1i3
nuclear receptor subfamily 1 group I member 3
enables
ISO
(PMID:9783588)
GO_Central
PMID:9783588
NCBI chrNW_004955468:12,985,105...13,002,850
G
Nr2f2
nuclear receptor subfamily 2 group F member 2
enables
ISO
(PMID:18798693)
UniProt
PMID:18798693
NCBI chrNW_004955416:24,148,052...24,154,406
Ensembl chrNW_004955416:24,141,888...24,168,585
G
Nr3c1
nuclear receptor subfamily 3 group C member 1
enables
ISO
(PMID:17635946)
UniProt
PMID:17635946
NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221
G
Nr5a1
nuclear receptor subfamily 5 group A member 1
enables
ISO
(PMID:23610160), (PMID:8205615)
ParkinsonsUK-UCL
PMID:8205615 PMID:23610160
NCBI chrNW_004955419:3,632,248...3,654,367
Ensembl chrNW_004955419:3,632,220...3,654,375
G
Nr5a2
nuclear receptor subfamily 5 group A member 2
enables
ISO
(PMID:15205472), (PMID:18410128), (PMID:21614002), (PMID:22187462), (PMID:22504882), (PMID:23737522), (PMID:26416531), (PMID:26553876), (PMID:27984042), (PMID:32433991), (PMID:38409506)
RGD UniProt
PMID:8668203 PMID:15205472 PMID:18410128 PMID:21614002 PMID:22187462 PMID:22504882 PMID:23737522 PMID:26416531 PMID:26553876 PMID:27984042 PMID:32433991 PMID:38409506 More...
RGD:68248
NCBI chrNW_004955406:36,263,257...36,415,494
Ensembl chrNW_004955406:36,263,184...36,415,525
G
Pgr
progesterone receptor
enables
ISO
(PMID:14681235)
MGI
PMID:14681235
NCBI chrNW_004955412:4,643,839...4,693,478
G
Ppara
peroxisome proliferator activated receptor alpha
enables
ISO
(PMID:12955147), (PMID:19955185) (PMID:29331071)
UniProt RGD
PMID:12189208 PMID:12955147 PMID:12966092 PMID:19955185 PMID:29331071
RGD:1580224 RGD:729665
NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500
G
Ppard
peroxisome proliferator activated receptor delta
enables
ISO
(PMID:12955147)
UniProt
PMID:12955147
NCBI chrNW_004955437:3,285,281...3,354,099
Ensembl chrNW_004955437:3,288,830...3,357,048
G
Pparg
peroxisome proliferator activated receptor gamma
enables
ISO
(PMID:16239304), (PMID:35710596) (PMID:10622252), (PMID:12955147), (PMID:16239304), (PMID:18293083)
UniProt GO_Central BHF-UCL
PMID:10622252 PMID:12955147 PMID:16239304 PMID:18293083 PMID:35710596
NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387
G
Rara
retinoic acid receptor alpha
enables
ISO
(PMID:21131358), (PMID:2825025) (PMID:15322135), (PMID:15528198)
ARUK-UCL MGI
PMID:2825025 PMID:15322135 PMID:15528198 PMID:21131358
NCBI chrNW_004955451:14,876,663...14,917,134
Ensembl chrNW_004955451:14,897,726...14,917,134
G
Rarb
retinoic acid receptor beta
enables
ISO
(PMID:2177841)
UniProt
PMID:2177841
NCBI chrNW_004955430:17,067,536...17,457,558
Ensembl chrNW_004955430:17,295,174...17,460,045
G
Rarg
retinoic acid receptor gamma
ISO
RGD
PMID:11072095
RGD:1300463
NCBI chrNW_004955458:480,257...501,172
Ensembl chrNW_004955458:480,070...501,356
G
Rxra
retinoid X receptor alpha
enables contributes_to
ISO
(PMID:1651173), (PMID:20219900), (PMID:25592151), (PMID:7990953), (PMID:9267036) (PMID:17107947) (PMID:1312497), (PMID:15322135)
BHF-UCL MGI
PMID:1312497 PMID:1651173 PMID:7990953 PMID:9267036 PMID:15322135 PMID:17107947 PMID:20219900 PMID:25592151 More...
NCBI chrNW_004955513:3,313,544...3,386,544
Ensembl chrNW_004955513:3,335,897...3,386,994
G
Rxrb
retinoid X receptor beta
enables
ISO
(PMID:1662118), (PMID:7990953)
GO_Central RGD
PMID:1662118 PMID:7990953
RGD:729677
NCBI chrNW_004955437:1,767,833...1,774,401
Ensembl chrNW_004955437:1,767,833...1,774,401
G
Rxrg
retinoid X receptor gamma
enables
ISO
(PMID:1312497)
MGI
PMID:1312497
NCBI chrNW_004955462:11,238,963...11,281,905
Ensembl chrNW_004955462:11,238,794...11,281,956
G
Srebf1
sterol regulatory element binding transcription factor 1
enables
ISO
(PMID:23610160)
ParkinsonsUK-UCL
PMID:23610160
NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046
G
Stat3
signal transducer and activator of transcription 3
enables
ISO
(PMID:17324931)
BHF-UCL
PMID:17324931
NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687
G
Thra
thyroid hormone receptor alpha
enables
ISO
(PMID:15466465), (PMID:18052923), (PMID:8710870) (PMID:15322135)
UniProt MGI
PMID:8710870 PMID:15322135 PMID:15466465 PMID:18052923
NCBI chrNW_004955451:14,731,746...14,743,545
Ensembl chrNW_004955451:14,731,746...14,744,367
G
Thrb
thyroid hormone receptor beta
enables
ISO
(PMID:20203194) (PMID:15466465)
MGI RGD UniProt
PMID:2457590 PMID:15466465 PMID:20203194
RGD:729962
NCBI chrNW_004955430:15,992,146...16,322,696
Ensembl chrNW_004955430:15,992,146...16,323,238
G
Vdr
vitamin D receptor
enables
ISO
(PMID:16549446), (PMID:17082781) (PMID:15322135) (PMID:28698609)
RGD BHF-UCL MGI UniProt
PMID:9579411 PMID:15322135 PMID:16549446 PMID:17082781 PMID:28698609
RGD:70308
NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
G
Abhd2
abhydrolase domain containing 2, acylglycerol lipase
enables
ISO
(PMID:26989199)
UniProt
PMID:26989199
NCBI chrNW_004955416:15,878,972...15,983,322
Ensembl chrNW_004955416:15,884,624...15,983,322
G
Esr1
estrogen receptor 1
ISO
17-beta-estradiol (E2)
RGD
PMID:17928626
RGD:5128669
NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
G
Esr2
estrogen receptor 2
ISO
17-beta-estradiol (E2)
RGD
PMID:17928626
RGD:5128669
NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
G
Nr3c2
nuclear receptor subfamily 3 group C member 2
ISO
RGD
PMID:17260968
RGD:1600931
NCBI chrNW_004955471:3,059,210...3,397,894
Ensembl chrNW_004955471:3,061,735...3,395,520
G
Pgr
progesterone receptor
enables
ISO
(PMID:10757795), (PMID:9620806) (PMID:16176985)
RGD UniProt MGI
PMID:9620806 PMID:10757795 PMID:11113338 PMID:16176985
RGD:1601290
NCBI chrNW_004955412:4,643,839...4,693,478
G
Ppara
peroxisome proliferator activated receptor alpha
enables
ISO
(PMID:19955185)
BHF-UCL
PMID:19955185
NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500
G
Vdr
vitamin D receptor
enables
ISO
(PMID:10678179), (PMID:12016314), (PMID:17082781)
UniProt
PMID:10678179 PMID:12016314 PMID:17082781
NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all