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ONTOLOGY REPORT - ANNOTATIONS


Term:ligand-modulated transcription factor activity
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Accession:GO:0098531 term browser browse the term
Definition:A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.
Comment:For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
Synonyms:exact_synonym: direct ligand regulated sequence-specific DNA binding transcription factor activity
 narrow_synonym: ligand-activated transcription factor activity


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ligand-modulated transcription factor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bach1 BTB domain and CNC homolog 1 enables ISO (PMID:21555518) UniProt PMID:21555518 NCBI chrNW_004955407:28,678,181...28,701,115
Ensembl chrNW_004955407:28,678,181...28,701,399
JBrowse link
G Rora RAR related orphan receptor A enables ISO (PMID:19965867) UniProt PMID:19965867 NCBI chrNW_004955450:14,262,199...14,434,611
Ensembl chrNW_004955450:14,262,190...14,425,233
JBrowse link
G Rorc RAR related orphan receptor C enables ISO (PMID:19965867) UniProt PMID:19965867 NCBI chrNW_004955589:590,653...616,784
Ensembl chrNW_004955589:590,743...616,694
JBrowse link
bile acid nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1 group H member 4 enables ISO PMID:12718893
(PMID:21757002)
PMID:10334992
(PMID:10334992), (PMID:21757002), (PMID:23767959)
UniProt
BHF-UCL
ParkinsonsUK-UCL
PMID:10334992 PMID:12718893 PMID:21757002 PMID:23767959 RGD:15090836 RGD:1625198 NCBI chrNW_004955405:36,160,360...36,236,258
Ensembl chrNW_004955405:36,160,049...36,237,751
JBrowse link
G Vdr vitamin D receptor enables ISO (PMID:12016314), (PMID:32354638) UniProt PMID:12016314 PMID:32354638 NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
JBrowse link
nuclear estrogen receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 enables ISO (PMID:15831516), (PMID:9338790), (PMID:9841876) CAFA PMID:9338790 PMID:9841876 PMID:15831516 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
JBrowse link
G Esr2 estrogen receptor 2 enables ISO (PMID:19126643), (PMID:24033289)
(PMID:29261182), (PMID:30113650)
ParkinsonsUK-UCL
UniProt
PMID:19126643 PMID:24033289 PMID:29261182 PMID:30113650 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 enables ISO (PMID:23545157)
(PMID:15539556), (PMID:15705806)
UniProt PMID:15539556 PMID:15705806 PMID:23545157 NCBI chrNW_004955460:8,790,798...8,794,902
Ensembl chrNW_004955460:8,790,798...8,794,902
JBrowse link
G Pde3a phosphodiesterase 3A enables ISO (PMID:31420216), (PMID:35104454) UniProt PMID:31420216 PMID:35104454 NCBI chrNW_004955413:16,340,827...16,642,731
Ensembl chrNW_004955413:16,340,918...16,643,214
JBrowse link
nuclear glucocorticoid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3 group C member 1 enables ISO (PMID:15199138), (PMID:7914432), (PMID:9237103) MGI PMID:7914432 PMID:9237103 PMID:15199138 NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221
JBrowse link
nuclear receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor enables
contributes_to
ISO PMID:7812217
(PMID:1314586), (PMID:33436590)
(PMID:10395741), (PMID:28602820), (PMID:32818467), (PMID:32866000)
(PMID:34521881)
UniProt PMID:1314586 PMID:7812217 PMID:10395741 PMID:28602820 PMID:32818467 More... RGD:8553947 NCBI chrNW_004955410:20,428,531...20,459,482
Ensembl chrNW_004955410:20,428,546...20,456,836
JBrowse link
G Ar androgen receptor enables
NOT|enables
ISO (PMID:12799378), (PMID:17277772), (PMID:19886863), (PMID:20048160), (PMID:25091737)
(PMID:12145204), (PMID:15199138), (PMID:18761815), (PMID:23786676)
(PMID:19345326)
(PMID:19244107)
BHF-UCL
MGI
UniProt
RGD
PMID:2341409 PMID:12145204 PMID:12799378 PMID:15199138 PMID:17277772 More... RGD:1298681 NCBI chrNW_004955475:7,013,960...7,192,473
Ensembl chrNW_004955475:7,013,960...7,186,069
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator contributes_to ISO (PMID:34521881)
(PMID:11043581)
UniProt
MGI
PMID:11043581 PMID:34521881 NCBI chrNW_004955588:159,462...233,047
Ensembl chrNW_004955588:159,462...233,047
JBrowse link
G Esr1 estrogen receptor 1 enables ISO (PMID:18722177)
(PMID:15831516)
(PMID:15322135)
MGI
BHF-UCL
PMID:15322135 PMID:15831516 PMID:18722177 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
JBrowse link
G Esr2 estrogen receptor 2 enables ISO (PMID:19126643) ParkinsonsUK-UCL PMID:19126643 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha enables ISO (PMID:12193589) GO_Central PMID:12193589 NCBI chrNW_004955445:12,925,248...12,962,501
Ensembl chrNW_004955445:12,924,662...12,984,281
JBrowse link
G Nkx3-1 NK3 homeobox 1 enables ISO (PMID:19886863) UniProt PMID:19886863 NCBI chrNW_004955403:46,807,846...46,809,924
Ensembl chrNW_004955403:46,806,178...46,836,310
JBrowse link
G Nr1h2 nuclear receptor subfamily 1 group H member 2 enables ISO (PMID:14739254) MGI PMID:14739254 NCBI chrNW_004955559:731,630...736,973
Ensembl chrNW_004955559:730,670...737,505
JBrowse link
G Nr1h3 nuclear receptor subfamily 1 group H member 3 enables
contributes_to
ISO (PMID:19481530)
(PMID:14739254)
(PMID:17107947)
GO_Central
MGI
BHF-UCL
PMID:14739254 PMID:17107947 PMID:19481530 NCBI chrNW_004955422:940,310...954,170
Ensembl chrNW_004955422:940,310...949,049
JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 enables ISO (PMID:27471003)
PMID:10334992
MGI
UniProt
PMID:10334992 PMID:27471003 RGD:15090836 NCBI chrNW_004955405:36,160,360...36,236,258
Ensembl chrNW_004955405:36,160,049...36,237,751
JBrowse link
G Nr1i2 nuclear receptor subfamily 1 group I member 2 enables ISO (PMID:12578355) UniProt
RGD
PMID:10967130 PMID:12578355 RGD:61490 NCBI chrNW_004955427:19,459,936...19,487,276
Ensembl chrNW_004955427:19,459,936...19,487,276
JBrowse link
G Nr1i3 nuclear receptor subfamily 1 group I member 3 enables ISO (PMID:9783588) GO_Central PMID:9783588 NCBI chrNW_004955468:12,985,105...13,002,850 JBrowse link
G Nr2f2 nuclear receptor subfamily 2 group F member 2 enables ISO (PMID:18798693) UniProt PMID:18798693 NCBI chrNW_004955416:24,148,052...24,154,406
Ensembl chrNW_004955416:24,141,888...24,168,585
JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 enables ISO (PMID:17635946) UniProt PMID:17635946 NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221
JBrowse link
G Nr5a1 nuclear receptor subfamily 5 group A member 1 enables ISO (PMID:23610160), (PMID:8205615) ParkinsonsUK-UCL PMID:8205615 PMID:23610160 NCBI chrNW_004955419:3,632,248...3,654,367
Ensembl chrNW_004955419:3,632,220...3,654,375
JBrowse link
G Nr5a2 nuclear receptor subfamily 5 group A member 2 enables ISO (PMID:15205472), (PMID:18410128), (PMID:21614002), (PMID:22187462), (PMID:22504882), (PMID:23737522), (PMID:26416531), (PMID:26553876), (PMID:27984042), (PMID:32433991), (PMID:38409506) RGD
UniProt
PMID:8668203 PMID:15205472 PMID:18410128 PMID:21614002 PMID:22187462 More... RGD:68248 NCBI chrNW_004955406:36,263,257...36,415,494
Ensembl chrNW_004955406:36,263,184...36,415,525
JBrowse link
G Pgr progesterone receptor enables ISO (PMID:14681235) MGI PMID:14681235 NCBI chrNW_004955412:4,643,839...4,693,478 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha enables ISO (PMID:12955147), (PMID:19955185)
(PMID:29331071)
UniProt
RGD
PMID:12189208 PMID:12955147 PMID:12966092 PMID:19955185 PMID:29331071 RGD:1580224 RGD:729665 NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500
JBrowse link
G Ppard peroxisome proliferator activated receptor delta enables ISO (PMID:12955147) UniProt PMID:12955147 NCBI chrNW_004955437:3,285,281...3,354,099
Ensembl chrNW_004955437:3,288,830...3,357,048
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma enables ISO (PMID:16239304), (PMID:35710596)
(PMID:10622252), (PMID:12955147), (PMID:16239304), (PMID:18293083)
UniProt
GO_Central
BHF-UCL
PMID:10622252 PMID:12955147 PMID:16239304 PMID:18293083 PMID:35710596 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387
JBrowse link
G Rara retinoic acid receptor alpha enables ISO (PMID:21131358), (PMID:2825025)
(PMID:15322135), (PMID:15528198)
ARUK-UCL
MGI
PMID:2825025 PMID:15322135 PMID:15528198 PMID:21131358 NCBI chrNW_004955451:14,876,663...14,917,134
Ensembl chrNW_004955451:14,897,726...14,917,134
JBrowse link
G Rarb retinoic acid receptor beta enables ISO (PMID:2177841) UniProt PMID:2177841 NCBI chrNW_004955430:17,067,536...17,457,558
Ensembl chrNW_004955430:17,295,174...17,460,045
JBrowse link
G Rarg retinoic acid receptor gamma ISO RGD PMID:11072095 RGD:1300463 NCBI chrNW_004955458:480,257...501,172
Ensembl chrNW_004955458:480,070...501,356
JBrowse link
G Rxra retinoid X receptor alpha enables
contributes_to
ISO (PMID:1651173), (PMID:20219900), (PMID:25592151), (PMID:7990953), (PMID:9267036)
(PMID:17107947)
(PMID:1312497), (PMID:15322135)
BHF-UCL
MGI
PMID:1312497 PMID:1651173 PMID:7990953 PMID:9267036 PMID:15322135 More... NCBI chrNW_004955513:3,313,544...3,386,544
Ensembl chrNW_004955513:3,335,897...3,386,994
JBrowse link
G Rxrb retinoid X receptor beta enables ISO (PMID:1662118), (PMID:7990953) GO_Central
RGD
PMID:1662118 PMID:7990953 RGD:729677 NCBI chrNW_004955437:1,767,833...1,774,401
Ensembl chrNW_004955437:1,767,833...1,774,401
JBrowse link
G Rxrg retinoid X receptor gamma enables ISO (PMID:1312497) MGI PMID:1312497 NCBI chrNW_004955462:11,238,963...11,281,905
Ensembl chrNW_004955462:11,238,794...11,281,956
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 enables ISO (PMID:23610160) ParkinsonsUK-UCL PMID:23610160 NCBI chrNW_004955577:171,425...183,669
Ensembl chrNW_004955577:171,425...186,046
JBrowse link
G Stat3 signal transducer and activator of transcription 3 enables ISO (PMID:17324931) BHF-UCL PMID:17324931 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687
JBrowse link
G Thra thyroid hormone receptor alpha enables ISO (PMID:15466465), (PMID:18052923), (PMID:8710870)
(PMID:15322135)
UniProt
MGI
PMID:8710870 PMID:15322135 PMID:15466465 PMID:18052923 NCBI chrNW_004955451:14,731,746...14,743,545
Ensembl chrNW_004955451:14,731,746...14,744,367
JBrowse link
G Thrb thyroid hormone receptor beta enables ISO (PMID:20203194)
(PMID:15466465)
MGI
RGD
UniProt
PMID:2457590 PMID:15466465 PMID:20203194 RGD:729962 NCBI chrNW_004955430:15,992,146...16,322,696
Ensembl chrNW_004955430:15,992,146...16,323,238
JBrowse link
G Vdr vitamin D receptor enables ISO (PMID:16549446), (PMID:17082781)
(PMID:15322135)
(PMID:28698609)
RGD
BHF-UCL
MGI
UniProt
PMID:9579411 PMID:15322135 PMID:16549446 PMID:17082781 PMID:28698609 RGD:70308 NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
JBrowse link
nuclear steroid receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase enables ISO (PMID:26989199) UniProt PMID:26989199 NCBI chrNW_004955416:15,878,972...15,983,322
Ensembl chrNW_004955416:15,884,624...15,983,322
JBrowse link
G Esr1 estrogen receptor 1 ISO 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
JBrowse link
G Esr2 estrogen receptor 2 ISO 17-beta-estradiol (E2) RGD PMID:17928626 RGD:5128669 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946
JBrowse link
G Nr3c2 nuclear receptor subfamily 3 group C member 2 ISO RGD PMID:17260968 RGD:1600931 NCBI chrNW_004955471:3,059,210...3,397,894
Ensembl chrNW_004955471:3,061,735...3,395,520
JBrowse link
G Pgr progesterone receptor enables ISO (PMID:10757795), (PMID:9620806)
(PMID:16176985)
RGD
UniProt
MGI
PMID:9620806 PMID:10757795 PMID:11113338 PMID:16176985 RGD:1601290 NCBI chrNW_004955412:4,643,839...4,693,478 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha enables ISO (PMID:19955185) BHF-UCL PMID:19955185 NCBI chrNW_004955413:30,306,563...30,366,245
Ensembl chrNW_004955413:30,307,219...30,359,500
JBrowse link
G Vdr vitamin D receptor enables ISO (PMID:10678179), (PMID:12016314), (PMID:17082781) UniProt PMID:10678179 PMID:12016314 PMID:17082781 NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14380
    transcription regulator activity 1064
      DNA-binding transcription factor activity 721
        ligand-modulated transcription factor activity 38
          ligand-modulated transcription activator activity 0
          ligand-modulated transcription repressor activity 0
          nuclear receptor activity + 35
paths to the root