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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 acts_upstream_of_or_within ISO (PMID:21881209) RGD PMID:21881209 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G C3 complement C3 involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P05555 (PMID:20199584), (PMID:22438044) 		Ensembl
RGD		 PMID:20199584 PMID:22438044 GO_REF:0000107 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G C5ar1 complement C5a receptor 1 involved_in ISO UniProtKB:P05067 (PMID:19561098) RGD PMID:19561098 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G Clu clusterin involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:27477018)
GO_REF:0000107 		RGD
Ensembl		 PMID:27477018 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Ide insulin degrading enzyme involved_in
acts_upstream_of_or_within 		IMP
IEA
ISO
IGI 		PMID:10684867
GO_REF:0000117
GO_REF:0000107
(PMID:20876579)
(PMID:26637123)
(PMID:10684867), (PMID:16511862)
PMID:19406747 		UniProt
Ensembl
RGD		 PMID:10684867 PMID:16511862 PMID:20876579 PMID:26637123 PMID:10684867 More... GO_REF:0000107 GO_REF:0000117, RGD:1627576, RGD:13210538 NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor involved_in ISO (PMID:19406747) RGD PMID:19406747 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Insr insulin receptor involved_in IMP PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO UniProtKB:P01027 (PMID:20199584), (PMID:22438044) RGD PMID:20199584 PMID:22438044 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:20199584) RGD PMID:20199584 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO
IEA 		UniProtKB:P05067|UniProtKB:P49768 (PMID:20005821)
GO_REF:0000107 		RGD
Ensembl		 PMID:20005821 GO_REF:0000107 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:19098903) RGD PMID:19098903 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in IMP PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:74,597,148...74,754,535 		JBrowse link
G Marco macrophage receptor with collagenous structure involved_in IMP PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chr13:34,169,011...34,210,340
Ensembl chr13:34,169,011...34,201,255 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in IDA
IEA
ISO
IBA 		PMID:19406747
GO_REF:0000117
GO_REF:0000107
UniProtKB:P05067 (PMID:16636059)
UniProtKB:Q61391 (PMID:12657655), (PMID:14749444), (PMID:15100223), (PMID:19057576)
GO_REF:0000033 		UniProt
Ensembl
RGD
GO_Central		 PMID:12657655 PMID:14749444 PMID:15100223 PMID:16636059 PMID:19057576 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:13210538 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463 		JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in IBA
ISO 		GO_REF:0000033
UniProtKB:P01027|UniProtKB:P05555 (PMID:11240025), (PMID:22438044) 		GO_Central
RGD		 PMID:11240025 PMID:22438044 GO_REF:0000033 NCBI chr16:59,421,250...59,507,070
Ensembl chr16:59,421,057...59,507,070 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA 		(PMID:27477018)
GO_REF:0000107 		RGD
Ensembl		 PMID:27477018 GO_REF:0000107 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:27477018)
GO_REF:0000107
(PMID:29859094) 		RGD
Ensembl		 PMID:27477018 PMID:29859094 GO_REF:0000107 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:20,144,334...20,151,779 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:27477018)
GO_REF:0000107 		RGD
Ensembl		 PMID:27477018 GO_REF:0000107 NCBI chr 1:94,800,372...94,804,307
Ensembl chr 1:94,800,117...94,804,299 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO 		GO_REF:0000024
(PMID:27472885) 		UniProt
RGD		 PMID:27472885 GO_REF:0000024 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:10,342,092...10,361,989 		JBrowse link
G Cd36 CD36 molecule involved_in ISO
IBA
IMP 		(PMID:18941241)
GO_REF:0000033 		RGD
GO_Central		 PMID:18941241 PMID:18941241 GO_REF:0000033, RGD:13825436 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cd36l1 CD36 molecule like 1 involved_in IBA
IMP 		GO_REF:0000033
PMID:18941241 		GO_Central PMID:18941241 GO_REF:0000033, RGD:13825436 NCBI chr 4:18,316,806...18,357,863
Ensembl chr 4:18,261,059...18,405,365 		JBrowse link
G Ide insulin degrading enzyme involved_in IMP
IEA
ISO 		PMID:18941241
GO_REF:0000107
(PMID:23525105) 		Ensembl
RGD		 PMID:23525105 PMID:18941241 GO_REF:0000107, RGD:13825436 NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO 		GO_REF:0000107
(PMID:22383525) 		Ensembl
RGD		 PMID:22383525 GO_REF:0000107 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675 		JBrowse link
G LOC134486712 platelet glycoprotein 4-like involved_in IBA
IMP 		GO_REF:0000033
PMID:18941241 		GO_Central PMID:18941241 GO_REF:0000033, RGD:13825436 NCBI chr 4:18,372,301...18,408,431 JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO
IBA
IEA 		(PMID:23152628), (PMID:24305823)
UniProtKB:P05067|UniProtKB:P49768 (PMID:21289173), (PMID:23152628), (PMID:24305823)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:21289173 PMID:23152628 PMID:24305823 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196 		JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in ISO
IEA 		(PMID:18289866)
GO_REF:0000107 		RGD
Ensembl		 PMID:18289866 GO_REF:0000107 NCBI chr 3:97,885,373...97,939,366
Ensembl chr 3:97,885,400...97,939,370 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in ISO
IEA
IMP 		UniProtKB:P05067 (PMID:15100223), (PMID:24825898)
GO_REF:0000107
PMID:18941241 		RGD
Ensembl		 PMID:15100223 PMID:24825898 PMID:18941241 GO_REF:0000107, RGD:13825436 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IEA 		(PMID:33097708)
GO_REF:0000117
GO_REF:0000107
(PMID:30617257), (PMID:31134514), (PMID:31980586) 		RGD
UniProt
Ensembl		 PMID:30617257 PMID:31134514 PMID:31980586 PMID:33097708 GO_REF:0000107 GO_REF:0000117 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:20,144,334...20,151,779 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain involved_in ISO
IEA 		(PMID:26005850)
GO_REF:0000107 		RGD
Ensembl		 PMID:26005850 GO_REF:0000107 NCBI chr10:72,014,984...72,073,308
Ensembl chr10:72,014,986...72,070,691 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO
IBA
IEA 		UniProtKB:Q13492 (PMID:26005850)
(PMID:20630619)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:20630619 PMID:26005850 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO
IEA 		(PMID:26005850)
GO_REF:0000107 		RGD
Ensembl		 PMID:26005850 GO_REF:0000107 NCBI chr14:79,876,002...79,888,011
Ensembl chr14:79,875,708...79,890,034 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
IEA 		UniProtKB:Q07954 (PMID:26005850)
UniProtKB:P05067-PRO_0000000092 (PMID:26005850)
GO_REF:0000107 		RGD
Ensembl		 PMID:26005850 GO_REF:0000107 NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:153,469,202...153,550,237 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family involved_in ISO
IEA 		UniProtKB:Q07954|UniProtKB:Q15907 (PMID:26005850)
GO_REF:0000107 		RGD
Ensembl		 PMID:26005850 GO_REF:0000107 NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:74,118,922...74,141,837 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO UniProtKB:P62491|UniProtKB:Q07954 (PMID:26005850) RGD PMID:26005850 NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:15,223,534...15,236,756 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in ISO UniProtKB:Q07954 (PMID:26005850) RGD PMID:26005850 NCBI chr 9:6,720,057...6,749,456
Ensembl chr 9:6,721,122...6,749,447 		JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 involved_in ISO
IEA 		(PMID:20876579)
GO_REF:0000107 		RGD
Ensembl		 PMID:20876579 GO_REF:0000107 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in IEA
ISO 		GO_REF:0000107
(PMID:20876579) 		Ensembl
RGD		 PMID:20876579 GO_REF:0000107 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P06804|UniProtKB:P15261 (PMID:17255335), (PMID:29061364) RGD PMID:17255335 PMID:29061364 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01580|UniProtKB:P06804 (PMID:17255335) RGD PMID:17255335 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in ISO
IEA 		UniProtKB:Q07954 (PMID:19098903)
GO_REF:0000107 		RGD
Ensembl		 PMID:19098903 GO_REF:0000107 NCBI chr14:79,876,002...79,888,011
Ensembl chr14:79,875,708...79,890,034 		JBrowse link
G Myocd myocardin acts_upstream_of ISO (PMID:19098903) RGD PMID:19098903 NCBI chr10:50,332,356...50,426,819
Ensembl chr10:50,332,356...50,426,819 		JBrowse link
G Pla2g3 phospholipase A2, group III acts_upstream_of_or_within ISO
IEA 		(PMID:26637123)
GO_REF:0000107 		RGD
Ensembl		 PMID:26637123 GO_REF:0000107 NCBI chr14:82,589,908...82,597,542
Ensembl chr14:82,591,862...82,597,542 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in ISO
IEA 		(PMID:19098903)
GO_REF:0000107 		RGD
Ensembl		 PMID:19098903 GO_REF:0000107 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
G Srf serum response factor acts_upstream_of ISO
IEA 		(PMID:19098903)
GO_REF:0000107 		RGD
Ensembl		 PMID:19098903 GO_REF:0000107 NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:21,924,076...21,933,337 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO UniProtKB:P01580|UniProtKB:P15261 (PMID:17255335) RGD PMID:17255335 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO 		GO_REF:0000024
(PMID:23467355) 		Alzheimers_University_of_Toronto
RGD		 PMID:23467355 GO_REF:0000024 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:10,342,092...10,361,989 		JBrowse link
G Apoe apolipoprotein E involved_in ISS
ISO 		GO_REF:0000024
(PMID:14741101) 		UniProt
RGD		 PMID:14741101 GO_REF:0000024 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G Il4 interleukin 4 involved_in IDA
ISO
IEA 		PMID:18941241
(PMID:18941241)
GO_REF:0000117 		RGD
UniProt		 PMID:18941241 PMID:18941241 GO_REF:0000117, RGD:13825436 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:26619118) RGD PMID:26619118 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA 		UniProtKB:Q14457 (PMID:27853422)
GO_REF:0000107 		RGD
Ensembl		 PMID:27853422 GO_REF:0000107 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IEA 		(PMID:31235932)
(PMID:26949937), (PMID:28802038), (PMID:30617257), (PMID:31235932)
GO_REF:0000107
GO_REF:0000117 		RGD
Ensembl
UniProt		 PMID:26949937 PMID:28802038 PMID:30617257 PMID:31235932 GO_REF:0000107 GO_REF:0000117 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:20,144,334...20,151,779 		JBrowse link
G Ttpa alpha tocopherol transfer protein acts_upstream_of_or_within ISO MGI:2386172 (PMID:26637123) RGD PMID:26637123 NCBI chr 5:38,294,415...38,315,471
Ensembl chr 5:38,292,665...38,315,804 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO
IEA 		(PMID:24446231)
GO_REF:0000107 		RGD
Ensembl		 PMID:24446231 GO_REF:0000107 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855 		JBrowse link
G App amyloid beta precursor protein acts_upstream_of ISO (PMID:19057576) RGD PMID:19057576 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Clu clusterin involved_in ISO
ISS
IEA 		(PMID:24446231)
GO_REF:0000024
GO_REF:0000107 		RGD
Alzheimers_University_of_Toronto
Ensembl		 PMID:24446231 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
Term paths to the root