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ONTOLOGY REPORT - ANNOTATIONS


Term:dendritic spine maintenance
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Accession:GO:0097062 term browser browse the term
Definition:The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.


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dendritic spine maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:23365224) MGI PMID:23365224 NCBI chr25:50,106,621...50,244,002
Ensembl chr25:50,216,483...50,241,621
JBrowse link
G CKAP5 cytoskeleton associated protein 5 acts_upstream_of_or_within ISO (PMID:23936366) MGI PMID:23936366 NCBI chr 1:18,504,588...18,584,635
Ensembl chr 1:18,484,372...18,586,623
JBrowse link
G CNTNAP2 contactin associated protein 2 involved_in ISO (PMID:31141683) MGI PMID:31141683 NCBI chr21:114,741,918...116,988,691 JBrowse link
G CTTN cortactin involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23365224) Ensembl
MGI
PMID:23365224 GO_REF:0000107 NCBI chr 1:4,139,045...4,176,962
Ensembl chr 1:4,137,814...4,176,446
JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr29:17,212,206...17,534,036
Ensembl chr29:17,459,404...17,526,930
JBrowse link
G INSR insulin receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr 6:6,625,951...6,803,610
Ensembl chr 6:6,630,777...6,803,592
JBrowse link
G ITGA3 integrin subunit alpha 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:23595732) MGI
Ensembl
PMID:23595732 GO_REF:0000107 NCBI chr16:43,248,341...43,282,045
Ensembl chr16:43,250,435...43,281,670
JBrowse link
G ITPKA inositol-trisphosphate 3-kinase A acts_upstream_of_or_within ISO PMID:19890013 MGI PMID:19890013 RGD:8553536 NCBI chr26:41,502,417...41,512,131 JBrowse link
G MTMR2 myotubularin related protein 2 involved_in ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 1:87,090,401...87,181,057
Ensembl chr 1:87,087,191...87,180,497
JBrowse link
G PICK1 protein interacting with PRKCA 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:20,758,199...20,778,210
Ensembl chr19:20,759,960...20,779,514
JBrowse link
G TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21068316) Ensembl
MGI
PMID:21068316 GO_REF:0000107 NCBI chr10:44,344,779...44,616,653
Ensembl chr10:44,376,139...44,614,987
JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31980586) ARUK-UCL PMID:31980586 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087
JBrowse link
negative regulation of dendritic spine maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E acts_upstream_of_or_within ISO (PMID:24328732) Alzheimers_University_of_Toronto PMID:24328732 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438
JBrowse link
G CFL1 cofilin 1 ISO RGD PMID:23974706 RGD:11570553 NCBI chr 1:8,408,560...8,410,564 JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:61,988,265...62,218,756
Ensembl chr13:62,159,874...62,219,672
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B involved_in ISO (PMID:22820466) ARUK-UCL PMID:22820466 NCBI chr11:13,444,155...13,873,034
Ensembl chr11:13,456,968...13,873,202
JBrowse link
G PRNP prion protein (Kanno blood group) involved_in ISO (PMID:24012003)
(PMID:22820466)
ARUK-UCL PMID:22820466 PMID:24012003 NCBI chr 2:33,368,020...33,384,556
Ensembl chr 2:33,369,629...33,370,366
JBrowse link
positive regulation of dendritic spine maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:24328732) Alzheimers_University_of_Toronto
Ensembl
PMID:24328732 GO_REF:0000107 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:30206770 RGD:405650589 NCBI chr10:97,099,090...98,281,697 JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 involved_in ISO PMID:17360908 ARUK-UCL PMID:17360908 RGD:12793018 NCBI chr12:1,020,556...1,050,568
Ensembl chr12:1,019,263...1,050,231
JBrowse link
G INS insulin involved_in ISO (PMID:19188609) ARUK-UCL PMID:19188609 NCBI chr 1:1,965,128...1,969,090 JBrowse link
G INS insulin involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 1:1,965,200...1,966,613 JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:60,759,411...60,959,558
Ensembl chr17:60,911,264...60,959,603
JBrowse link
G ZMYND8 zinc finger MYND-type containing 8 ISO RGD PMID:24117785 RGD:8554267 NCBI chr 2:16,547,144...16,696,729
Ensembl chr 2:16,622,702...16,696,878
JBrowse link
G ZNF804A zinc finger protein 804A involved_in ISO PMID:27837918 UniProt PMID:27837918 RGD:13210564 NCBI chr10:70,094,213...70,431,682 JBrowse link
regulation of dendritic spine maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD17B abhydrolase domain containing 17B, depalmitoylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:82,937,311...82,985,263
Ensembl chr12:82,937,238...82,985,283
JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:23921129) ARUK-UCL PMID:23921129 NCBI chr 2:66,037,224...66,320,860
Ensembl chr 2:66,037,261...66,321,306
JBrowse link
G HOMER1 homer scaffold protein 1 involved_in ISO PMID:19345194 UniProt PMID:19345194 RGD:8553291 NCBI chr 4:73,591,105...73,729,680
Ensembl chr 4:73,589,495...73,728,353
JBrowse link
G LOC103223672 low affinity immunoglobulin gamma Fc region receptor II-b involved_in ISO (PMID:23921129) ARUK-UCL PMID:23921129 NCBI chr20:2,398,425...2,413,328 JBrowse link
G VPS35 VPS35 retromer complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,509,037...32,539,371
Ensembl chr 5:32,508,580...32,539,343
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19803
    cellular process 19325
      cellular component organization or biogenesis 8843
        cellular component organization 8620
          cellular component maintenance 99
            dendritic spine maintenance 29
              negative regulation of dendritic spine maintenance 5
              positive regulation of dendritic spine maintenance 8
              regulation of dendritic spine maintenance + 17
Path 2
Term Annotations click to browse term
  biological_process 19803
    cellular process 19325
      cellular component organization or biogenesis 8843
        cellular component organization 8620
          cell junction organization 936
            synapse organization 673
              postsynapse organization 325
                dendritic spine organization 113
                  dendritic spine maintenance 29
                    negative regulation of dendritic spine maintenance 5
                    positive regulation of dendritic spine maintenance 8
                    regulation of dendritic spine maintenance + 17
paths to the root