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ONTOLOGY REPORT - ANNOTATIONS


Term:dendritic spine maintenance
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Accession:GO:0097062 term browser browse the term
Definition:The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.



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dendritic spine maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:23365224) MGI PMID:23365224 NCBI chr 1:154,586,423...154,711,621
Ensembl chr 1:158,280,994...158,313,915
JBrowse link
G CKAP5 cytoskeleton associated protein 5 acts_upstream_of_or_within ISO (PMID:23936366) MGI PMID:23936366 NCBI chr11:46,694,967...46,797,500
Ensembl chr11:47,252,752...47,329,274
JBrowse link
G CNTNAP2 contactin associated protein 2 involved_in ISO (PMID:31141683) MGI PMID:31141683 NCBI chr 7:137,858,607...140,150,820
Ensembl chr 7:150,345,240...152,626,818
JBrowse link
G CTTN cortactin involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23365224) Ensembl
MGI
PMID:23365224 GO_REF:0000107 NCBI chr11:65,500,074...65,539,158
Ensembl chr11:68,794,162...68,823,857
JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974
JBrowse link
G INSR insulin receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chr19:6,393,407...6,578,234
Ensembl chr19:7,260,246...7,414,889
JBrowse link
G ITGA3 integrin subunit alpha 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23595732) Ensembl
MGI
PMID:23595732 GO_REF:0000107 NCBI chr17:44,145,974...44,181,343
Ensembl chr17:49,019,892...49,055,245
JBrowse link
G ITPKA inositol-trisphosphate 3-kinase A acts_upstream_of_or_within ISO PMID:19890013 MGI PMID:19890013 RGD:8553536 NCBI chr15:20,434,532...20,444,389
Ensembl chr15:38,675,600...38,684,779
JBrowse link
G MTMR2 myotubularin related protein 2 involved_in ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr11:90,839,577...90,929,731
Ensembl chr11:94,367,038...94,457,138
JBrowse link
G PICK1 protein interacting with PRKCA 1 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr22:36,796,015...36,814,469 JBrowse link
G POLR2F RNA polymerase II, I and III subunit F involved_in ISO PMID:18297063 UniProt PMID:18297063 RGD:8554748 NCBI chr22:18,868,872...18,988,918
Ensembl chr22:36,796,015...36,814,469
JBrowse link
G TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21068316) Ensembl
MGI
PMID:21068316 GO_REF:0000107 NCBI chr2B:46,251,797...46,521,577
Ensembl chr2B:163,729,504...163,895,940
JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578
JBrowse link
negative regulation of dendritic spine maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E acts_upstream_of_or_within ISO (PMID:24328732) Alzheimers_University_of_Toronto PMID:24328732 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
JBrowse link
G CFL1 cofilin 1 ISO RGD PMID:23974706 RGD:11570553 NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:109,469,750...109,684,086
Ensembl chr 6:113,545,944...113,604,451
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B involved_in ISO (PMID:22820466) ARUK-UCL PMID:22820466 NCBI chr12:13,543,104...13,987,437
Ensembl chr12:13,969,387...14,388,799
JBrowse link
G PRNP prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:4,713,616...4,728,847
Ensembl chr20:4,523,155...4,523,916
JBrowse link
positive regulation of dendritic spine maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:24328732) Alzheimers_University_of_Toronto
Ensembl
PMID:24328732 GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:30206770 RGD:405650589 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 involved_in ISO PMID:17360908 ARUK-UCL PMID:17360908 RGD:12793018 NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382
JBrowse link
G INS insulin involved_in ISO (PMID:19188609) ARUK-UCL PMID:19188609 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,022,321...11,071,747
Ensembl chr 6:11,297,701...11,420,186
JBrowse link
G ZMYND8 zinc finger MYND-type containing 8 ISO RGD PMID:24117785 RGD:8554267 NCBI chr20:43,540,819...43,701,322
Ensembl chr20:44,624,487...44,772,032
JBrowse link
G ZNF804A zinc finger protein 804A involved_in ISO PMID:27837918 UniProt PMID:27837918 RGD:13210564 NCBI chr2B:71,872,807...72,216,720
Ensembl chr2B:189,942,181...190,019,736
JBrowse link
regulation of dendritic spine maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD17B abhydrolase domain containing 17B, depalmitoylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:52,900,834...52,946,917
Ensembl chr 9:70,606,487...70,654,637
JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:23921129) ARUK-UCL PMID:23921129 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
JBrowse link
G FCGR2B Fc gamma receptor IIb involved_in ISO (PMID:23921129) ARUK-UCL PMID:23921129 NCBI chr 1:137,074,342...137,090,962
Ensembl chr 1:140,882,043...140,890,637
JBrowse link
G HOMER1 homer scaffold protein 1 involved_in ISO PMID:19345194 UniProt PMID:19345194 RGD:8553291 NCBI chr 5:35,794,627...35,936,111
Ensembl chr 5:36,064,665...36,205,928
JBrowse link
G VPS35 VPS35 retromer complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:26,924,901...26,954,443
Ensembl chr16:45,817,371...45,846,531
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19444
    cellular process 18997
      cellular component organization or biogenesis 8467
        cellular component organization 8265
          cellular component maintenance 95
            dendritic spine maintenance 29
              negative regulation of dendritic spine maintenance 5
              positive regulation of dendritic spine maintenance 7
              regulation of dendritic spine maintenance + 16
Path 2
Term Annotations click to browse term
  biological_process 19444
    cellular process 18997
      cellular component organization or biogenesis 8467
        cellular component organization 8265
          cell junction organization 920
            synapse organization 671
              postsynapse organization 327
                dendritic spine organization 111
                  dendritic spine maintenance 29
                    negative regulation of dendritic spine maintenance 5
                    positive regulation of dendritic spine maintenance 7
                    regulation of dendritic spine maintenance + 16
paths to the root