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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingolipid mediated signaling pathway
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Accession:GO:0090520 term browser browse the term
Definition:The series of molecular signals mediated by a sphingolipid.
Synonyms:exact_synonym: sphingolipid mediated signal transduction
 narrow_synonym: ceramide 1-phosphate signaling pathway;   ceramide signaling pathway;   sphingosine signaling pathway
 related_synonym: sphingolipid signaling pathway


show annotations for term's descendants           Sort by:
sphingolipid mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 acts_upstream_of_or_within ISO
IEA		 (PMID:23651497)
GO_REF:0000107		 RGD
Ensembl		 PMID:23651497 GO_REF:0000107 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Sphk1 sphingosine kinase 1 acts_upstream_of_or_within ISO (PMID:23651497) RGD PMID:23651497 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
positive regulation of sphingolipid mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klf14 KLF transcription factor 14 acts_upstream_of_or_within ISO
IEA		 MGI:3812953 (PMID:24759103)
GO_REF:0000107		 RGD
Ensembl		 PMID:24759103 GO_REF:0000107 NCBI chr 4:60,521,363...60,524,285
Ensembl chr 4:59,554,011...59,556,933 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:11792700)		 Ensembl
RGD		 PMID:11792700 GO_REF:0000107 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
regulation of sphingolipid mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plpp3 phospholipid phosphatase 3 acts_upstream_of_or_within ISO MGI:2176173|MGI:3723633 (PMID:21319224) RGD PMID:21319224 NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:119,927,085...120,002,205 		JBrowse link
sphingosine-1-phosphate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO
IEA		 (PMID:18558630)
GO_REF:0000107		 RGD
Ensembl		 PMID:18558630 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ezr ezrin involved_in ISO
IEA		 (PMID:23106337)
GO_REF:0000107		 RGD
Ensembl		 PMID:23106337 GO_REF:0000107 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Gpr3 G protein-coupled receptor 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:150,695,406...150,698,526
Ensembl chr 5:145,411,510...145,414,590 		JBrowse link
G Gpr6 G protein-coupled receptor 6 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:46,072,480...46,075,251
Ensembl chr20:44,489,853...44,492,624 		JBrowse link
G Mfsd2b MFSD2 lysolipid transporter B, sphingolipid involved_in ISO (PMID:33785361) RGD PMID:33785361 NCBI chr 6:33,589,623...33,602,477
Ensembl chr 6:27,870,518...27,882,159 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in ISO
IEA		 (PMID:18558630)
UniProtKB:O35904 (PMID:18558630)
GO_REF:0000107		 RGD
Ensembl		 PMID:18558630 GO_REF:0000107 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma involved_in ISO
IEA		 (PMID:18558630)
GO_REF:0000107		 RGD
Ensembl		 PMID:18558630 GO_REF:0000107 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:18558630) RGD PMID:18558630 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(PMID:11032855)
GO_REF:0000033
(PMID:22344443)		 UniProt
Ensembl
RGD
GO_Central		 PMID:11032855 PMID:22344443 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 involved_in ISO
IEA
IBA		 (PMID:23106337)
GO_REF:0000108
GO_REF:0000033		 RGD
GOC
GO_Central		 PMID:23106337 GO_REF:0000033 GO_REF:0000108 NCBI chr 8:27,779,452...27,790,344
Ensembl chr 8:19,502,627...19,523,574 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:13,932,773...13,946,213
Ensembl chr17:13,781,050...13,794,505 		JBrowse link
G S1pr4 sphingosine-1-phosphate receptor 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:8,858,528...8,860,804
Ensembl chr 7:8,208,098...8,211,893 		JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:28,062,841...28,068,013
Ensembl chr 8:19,786,663...19,791,795 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:105,317,332...105,324,985
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:23103166), (PMID:33785361), (PMID:34260944)
MGI:4460276|MGI:5426395 (PMID:22406534), (PMID:23180825)		 GO_Central
Ensembl
RGD		 PMID:22406534 PMID:23103166 PMID:23180825 PMID:33785361 PMID:34260944 GO_REF:0000033 GO_REF:0000107 NCBI chr10:57,565,909...57,604,546
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      signal transduction 7301
        sphingolipid mediated signaling pathway 20
          negative regulation of sphingolipid mediated signaling pathway 0
          positive regulation of sphingolipid mediated signaling pathway 2
          regulation of sphingolipid mediated signaling pathway + 3
          sphingosine-1-phosphate receptor signaling pathway 16
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          signal transduction 7301
            sphingolipid mediated signaling pathway 20
              negative regulation of sphingolipid mediated signaling pathway 0
              positive regulation of sphingolipid mediated signaling pathway 2
              regulation of sphingolipid mediated signaling pathway + 3
              sphingosine-1-phosphate receptor signaling pathway 16
paths to the root