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ONTOLOGY REPORT - ANNOTATIONS

Term:replicative senescence
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Accession:GO:0090399 term browser browse the term
Definition:The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening.
Synonyms:only_in_taxon: NCBITaxon:33208 ! Metazoa


show annotations for term's descendants           Sort by:
replicative senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:14720514) RGD PMID:14720514 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Ctc1 CST telomere replication complex component 1 acts_upstream_of_or_within ISO MGI:5427642 (PMID:22531781) RGD PMID:22531781 NCBI chr10:53,714,614...53,735,298
Ensembl chr10:53,714,644...53,735,298 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO MGI:2183944|MGI:2183945 (PMID:17173483), (PMID:9197240) RGD PMID:9197240 PMID:17173483 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in ISO
IEA
ISS		 (PMID:20876573)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20876573 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Pla2r1 phospholipase A2 receptor 1 involved_in ISO
ISS		 (PMID:19197340)
GO_REF:0000024		 RGD
UniProt		 PMID:19197340 GO_REF:0000024 NCBI chr 3:44,883,943...45,013,793
Ensembl chr 3:44,883,943...45,013,660 		JBrowse link
G Romo1 reactive oxygen species modulator 1 involved_in ISO (PMID:18836179) RGD PMID:18836179 NCBI chr 3:144,659,709...144,661,310
Ensembl chr 3:144,659,826...144,661,310 		JBrowse link
G Serpine1 serpin family E member 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:16862142)		 Ensembl
UniProt
RGD		 PMID:16862142 GO_REF:0000024 GO_REF:0000107 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO (PMID:9454332) RGD PMID:9454332 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO
IEA		 (PMID:19951988)
GO_REF:0000107		 RGD
Ensembl		 PMID:19951988 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wnt16 Wnt family member 16 involved_in ISO (PMID:19951988) RGD PMID:19951988 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380 		JBrowse link
G Wrn WRN RecQ like helicase acts_upstream_of_or_within ISO MGI:2386438 (PMID:10757812) RGD PMID:10757812 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
positive regulation of replicative senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir21 microRNA 21 involved_in ISO (PMID:23496142) RGD PMID:23496142 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      cell cycle process 1310
        replicative senescence 15
          negative regulation of replicative senescence 0
          positive regulation of replicative senescence 1
          regulation of replicative senescence + 1
Path 2
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      cell cycle 1637
        cell cycle process 1310
          replicative senescence 15
            negative regulation of replicative senescence 0
            positive regulation of replicative senescence 1
            regulation of replicative senescence + 1
paths to the root