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ONTOLOGY REPORT - ANNOTATIONS

Term:S-nitrosoglutathione reductase (NADH) activity
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Accession:GO:0080007 term browser browse the term
Definition:Catalysis of the reaction: S-nitrosoglutathione + NADH + H+ = S-(hydroxysulfenamide)glutathione + NAD+.
Comment:S-(hydroxysulfenamide)glutathione (GSNHOH) is an unstable intermediate. At high GSH levels, it is decomposed to glutathione disulfide (GSSG) and hydroxylamine. At low GSH levels, GSNHOH spontaneously converts to glutathione sulfinamid (GSONH2), which can be hydrolyzed to glutathione sulfinic acid (GSOOH) and ammonia. {xref="PMID:30795534"}
Synonyms:xref: MetaCyc:RXN-17884;   RHEA:78371


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S-nitrosoglutathione reductase (NADH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 enables ISO (PMID:31649033) RGD PMID:31649033 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
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  molecular_function 20633
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            S-nitrosoglutathione reductase (NADH) activity 2
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