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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 17 type immune response
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Accession:GO:0072538 term browser browse the term
Definition:An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22.
Synonyms:exact_synonym: Th17 immune response


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T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il17ra interleukin 17 receptor A involved_in ISO (PMID:28561022) RGD PMID:28561022 NCBI chr 4:155,339,742...155,362,382
Ensembl chr 4:153,667,534...153,690,174 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO
IEA		 (PMID:28561022)
GO_REF:0000107		 RGD
Ensembl		 PMID:28561022 GO_REF:0000107 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Phb1 prohibitin 1 involved_in ISO
ISS		 (PMID:31899195)
GO_REF:0000024		 RGD
UniProt		 PMID:31899195 GO_REF:0000024 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO
IEA		 (PMID:31899195)
GO_REF:0000107		 RGD
Ensembl		 PMID:31899195 GO_REF:0000107 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO (PMID:28561022) RGD PMID:28561022 NCBI chr20:44,565,992...44,609,240
Ensembl chr20:43,011,450...43,054,667 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO
IEA		 (PMID:24463518)
GO_REF:0000107		 RGD
Ensembl		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO
IEA		 (PMID:23169781)
GO_REF:0000107		 RGD
Ensembl		 PMID:23169781 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (PMID:25642768) RGD PMID:25642768 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) RGD PMID:18792410 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Pf4 platelet factor 4 IDA RGD PMID:24986443 RGD:329901907 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO
IEA		 (PMID:25282160)
GO_REF:0000107		 RGD
Ensembl		 PMID:25282160 GO_REF:0000107 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr 3:41,531,319...41,596,496
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO		 GO_REF:0000107
(PMID:25642768)		 Ensembl
RGD		 PMID:25642768 GO_REF:0000107 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO
IEA		 (PMID:21151104)
GO_REF:0000107		 RGD
Ensembl		 PMID:21151104 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO
IEA		 MGI:3530739 (PMID:23034280)
GO_REF:0000107		 RGD
Ensembl		 PMID:23034280 GO_REF:0000107 NCBI chr 2:177,093,569...177,111,894
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:25282160)		 UniProt
Ensembl
RGD		 PMID:25282160 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule involved_in ISO (PMID:24752896) RGD PMID:24752896 NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) RGD PMID:20696842 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lgals1 galectin 1 involved_in ISO
IEA		 (PMID:24752896)
GO_REF:0000107		 RGD
Ensembl		 PMID:24752896 GO_REF:0000107 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO (PMID:28065600) RGD PMID:28065600 NCBI chr 4:117,098,358...117,114,673
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO
IEA		 (PMID:20696842)
GO_REF:0000107		 RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO
IEA		 (PMID:21151104)
GO_REF:0000107		 RGD
Ensembl		 PMID:21151104 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) RGD PMID:24107315 NCBI chr13:76,366,790...76,440,673
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
negative regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27ra interleukin 27 receptor subunit alpha involved_in ISO
IEA		 UniProtKB:P35951 (PMID:22927332)
GO_REF:0000107		 RGD
Ensembl		 PMID:22927332 GO_REF:0000107 NCBI chr19:41,014,730...41,026,740
Ensembl chr19:24,109,972...24,121,938 		JBrowse link
G Smad7 SMAD family member 7 involved_in ISO
IEA		 (PMID:25642768)
GO_REF:0000107		 RGD
Ensembl		 PMID:25642768 GO_REF:0000107 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO
IEA		 (PMID:25282160)
GO_REF:0000107		 RGD
Ensembl		 PMID:25282160 GO_REF:0000107 NCBI chr18:61,212,290...61,266,272
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (PMID:19838199) RGD PMID:19838199 NCBI chr 1:163,266,165...163,266,259
Ensembl chr 1:153,854,029...153,854,123 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr 1:94,808,459...94,824,726
Ensembl chr 1:85,680,861...85,690,447 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO
IEA		 (PMID:26098997)
GO_REF:0000107		 RGD
Ensembl		 PMID:26098997 GO_REF:0000107 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28262505)		 UniProt
Ensembl
RGD		 PMID:28262505 GO_REF:0000024 GO_REF:0000107 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:19501566)		 GO_Central
Ensembl
RGD		 PMID:19501566 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:36171294)		 UniProt
Ensembl
RGD		 PMID:36171294 GO_REF:0000024 GO_REF:0000107 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
positive regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arid5a AT-rich interaction domain 5A involved_in ISO (PMID:27022145) RGD PMID:27022145 NCBI chr 9:46,030,513...46,058,729
Ensembl chr 9:38,534,590...38,547,597 		JBrowse link
G Card9 caspase recruitment domain family, member 9 involved_in ISO
IEA		 (PMID:24231284), (PMID:29080677)
GO_REF:0000107
(PMID:24470469), (PMID:32358020)		 RGD
Ensembl		 PMID:24231284 PMID:24470469 PMID:29080677 PMID:32358020 GO_REF:0000107 NCBI chr 3:29,569,907...29,578,402
Ensembl chr 3:9,171,815...9,180,237 		JBrowse link
G Clec4a C-type lectin domain family 4, member A involved_in ISO (PMID:32358020) RGD PMID:32358020 NCBI chr 4:158,026,138...158,119,904
Ensembl chr 4:156,414,688...156,432,402 		JBrowse link
G Clec6a-ps1 C-type lectin domain family 6, member A, pseudogene 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:158,225,100...158,244,722
Ensembl chr 4:156,539,408...156,558,605
Ensembl chr 4:156,539,408...156,558,605 		JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (PMID:32358020) RGD PMID:32358020 NCBI chr 4:164,588,737...164,599,953
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IEA		 (PMID:19501566)
GO_REF:0000107		 RGD
Ensembl		 PMID:19501566 GO_REF:0000107 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923 		JBrowse link
G Mir301a microRNA 301a acts_upstream_of_or_within ISO (PMID:22517757) RGD PMID:22517757 NCBI chr10:72,422,599...72,422,698
Ensembl chr10:71,925,336...71,925,435 		JBrowse link
G Nlrp10 NLR family, pyrin domain containing 10 involved_in ISO
IEA		 (PMID:23071280)
GO_REF:0000107		 RGD
Ensembl		 PMID:23071280 GO_REF:0000107 NCBI chr 1:172,357,648...172,365,205
Ensembl chr 1:162,922,806...162,930,363 		JBrowse link
G Prkcq protein kinase C, theta involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:16493044)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:16493044 GO_REF:0000024 GO_REF:0000107 NCBI chr17:72,156,215...72,288,508
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) RGD PMID:19050256 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) RGD PMID:19050256 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Mir301a microRNA 301a acts_upstream_of_or_within ISO (PMID:22517757) RGD PMID:22517757 NCBI chr10:72,422,599...72,422,698
Ensembl chr10:71,925,336...71,925,435 		JBrowse link
regulation of T-helper 17 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephb2 Eph receptor B2 IDA RGD PMID:33722292 RGD:127285641 NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:25065622) RGD PMID:25065622 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (PMID:25470037) RGD PMID:25470037 NCBI chr  X:17,296,750...17,331,257
Ensembl chr  X:14,626,164...14,659,573 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:20421391), (PMID:21572431)		 UniProt
Ensembl
RGD		 PMID:20421391 PMID:21572431 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in ISO
IEA		 (PMID:23241884)
GO_REF:0000107		 RGD
Ensembl		 PMID:23241884 GO_REF:0000107 NCBI chr 1:252,508,594...252,550,269
Ensembl chr 1:242,559,365...242,601,447 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930 (PMID:20383124) RGD PMID:20383124 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Rora RAR-related orphan receptor A involved_in ISO
IEA		 (PMID:18164222)
GO_REF:0000107		 RGD
Ensembl		 PMID:18164222 GO_REF:0000107 NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Rorc RAR-related orphan receptor C acts_upstream_of_or_within
involved_in		 ISO (PMID:18792410)
(PMID:16990136), (PMID:18164222)
MGI:2386114 (PMID:20383124)		 RGD PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19578362), (PMID:22983707)		 UniProt
Ensembl
RGD		 PMID:19578362 PMID:22983707 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16990136), (PMID:27893700)		 UniProt
RGD		 PMID:16990136 PMID:27893700 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor involved_in ISS
ISO		 GO_REF:0000024
(PMID:27893700)		 UniProt
RGD		 PMID:27893700 GO_REF:0000024 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO
IEA		 (PMID:22983707)
GO_REF:0000107		 RGD
Ensembl		 PMID:22983707 GO_REF:0000107 NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Ly9 lymphocyte antigen 9 involved_in ISO
IEA		 (PMID:22184727)
GO_REF:0000107		 RGD
Ensembl		 PMID:22184727 GO_REF:0000107 NCBI chr13:86,610,762...86,633,314
Ensembl chr13:84,079,458...84,100,823 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (PMID:25470037) RGD PMID:25470037 NCBI chr  X:17,296,750...17,331,257
Ensembl chr  X:14,626,164...14,659,573 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:86,916,956...86,937,697
Ensembl chr13:84,383,742...84,405,300 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28065600)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28065600 GO_REF:0000024 GO_REF:0000107 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    response to stimulus 11067
      immune response 2236
        adaptive immune response 668
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 474
            T-helper 17 type immune response 55
              T-helper 17 cell differentiation + 41
              negative regulation of T-helper 17 type immune response + 18
              positive regulation of T-helper 17 type immune response + 18
              regulation of T-helper 17 type immune response + 41
paths to the root