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ONTOLOGY REPORT - ANNOTATIONS

Term:N-terminal protein N-methyltransferase activity
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Accession:GO:0071885 term browser browse the term
Definition:Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser.
Synonyms:narrow_synonym: X-Pro-Lys N-terminal methyltransferase
 xref: EC:2.1.1.244


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N-terminal protein N-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ntmt1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 enables ISO
ISS
IBA
IEA		 (PMID:26543159)
GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
GO_REF:0000003		 RGD
UniProt
GO_Central
Ensembl		 PMID:26543159 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:14,093,374...14,110,565
Ensembl chr 3:14,093,977...14,110,663 		JBrowse link
G Ntmt2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 enables ISO
ISS
IBA
IEA		 (PMID:24090352)
GO_REF:0000024
GO_REF:0000033
GO_REF:0000107		 RGD
UniProt
GO_Central
Ensembl		 PMID:24090352 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:76,050,683...76,093,972
Ensembl chr13:76,053,127...76,093,972 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      catalytic activity, acting on a protein 2531
        protein methyltransferase activity 105
          N-terminal protein N-methyltransferase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      transferase activity 2476
        transferase activity, transferring one-carbon groups 215
          methyltransferase activity 204
            protein methyltransferase activity 105
              N-terminal protein N-methyltransferase activity 2
paths to the root