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ONTOLOGY REPORT - ANNOTATIONS

Term:thrombin-activated receptor signaling pathway
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Accession:GO:0070493 term browser browse the term
Definition:A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms:exact_synonym: thrombin receptor signaling pathway;   thrombin receptor signalling pathway


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thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:15632189) RGD PMID:15632189 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131 		JBrowse link
G F2 coagulation factor II, thrombin involved_in ISO
IEA		 (PMID:11309392)
GO_REF:0000107		 RGD
Ensembl		 PMID:11309392 GO_REF:0000107 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor involved_in
acts_upstream_of_or_within		 IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
MGI:88380 (PMID:18398001)
(PMID:1672265)		 Ensembl
UniProt
RGD		 PMID:1672265 PMID:18398001 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098 		JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase involved_in IEP PMID:19383433 UniProt PMID:19383433 RGD:8553438 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 involved_in ISO (PMID:12515716) RGD PMID:12515716 NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279 		JBrowse link
G Plek pleckstrin involved_in ISO
IEA		 (PMID:7782310)
(PMID:19190246)
GO_REF:0000107		 RGD
Ensembl		 PMID:7782310 PMID:19190246 GO_REF:0000107 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131 		JBrowse link
G Vps54 VPS54 subunit of GARP complex involved_in IEA
ISO		 GO_REF:0000107
MGI:1857091 (PMID:10952021)		 Ensembl
RGD		 PMID:10952021 GO_REF:0000107 NCBI chr14:95,378,821...95,455,871
Ensembl chr14:95,378,012...95,455,857 		JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase involved_in ISO
IEA		 (PMID:25198505)
GO_REF:0000107		 RGD
Ensembl		 PMID:25198505 GO_REF:0000107 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Snca synuclein alpha involved_in ISO
IEA		 (PMID:12239163)
GO_REF:0000107		 RGD
Ensembl		 PMID:12239163 GO_REF:0000107 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Stmn1 stathmin 1 involved_in ISO (PMID:25198505) RGD PMID:25198505 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      signal transduction 7183
        G protein-coupled receptor signaling pathway 2447
          thrombin-activated receptor signaling pathway 13
            negative regulation of thrombin-activated receptor signaling pathway 3
            positive regulation of thrombin-activated receptor signaling pathway 0
            regulation of thrombin-activated receptor signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20076
    biological regulation 13559
      regulation of biological process 13136
        signaling 7744
          signal transduction 7183
            G protein-coupled receptor signaling pathway 2447
              thrombin-activated receptor signaling pathway 13
                negative regulation of thrombin-activated receptor signaling pathway 3
                positive regulation of thrombin-activated receptor signaling pathway 0
                regulation of thrombin-activated receptor signaling pathway + 3
paths to the root