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ONTOLOGY REPORT - ANNOTATIONS

Term:nonhomologous end joining complex
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Accession:GO:0070419 term browser browse the term
Definition:A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.
Synonyms:exact_synonym: NHEJ complex;   non-homologous end joining complex


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nonhomologous end joining complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dclre1c DNA cross-link repair 1C part_of ISO
IEA
ISS		 (PMID:25941166)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:25941166 GO_REF:0000024 GO_REF:0000107 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Lig4 DNA ligase 4 part_of ISO (PMID:20383123), (PMID:25941166) RGD PMID:20383123 PMID:25941166 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 part_of ISO
ISS		 (PMID:20383123), (PMID:25941166)
GO_REF:0000024		 RGD
UniProt		 PMID:20383123 PMID:25941166 GO_REF:0000024 NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Paxx PAXX, non-homologous end joining factor part_of ISO
IBA		 (PMID:25670504), (PMID:25941166)
GO_REF:0000033		 RGD
GO_Central		 PMID:25670504 PMID:25941166 GO_REF:0000033 NCBI chr 3:8,274,762...8,276,322
Ensembl chr 3:8,274,762...8,276,521 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit part_of ISO (PMID:20383123), (PMID:25941166) RGD PMID:20383123 PMID:25941166 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 part_of ISO (PMID:20383123), (PMID:25941166) RGD PMID:20383123 PMID:25941166 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 part_of ISO (PMID:20383123), (PMID:25941166) RGD PMID:20383123 PMID:25941166 NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 part_of ISO (PMID:20383123), (PMID:25941166) RGD PMID:20383123 PMID:25941166 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
DNA ligase IV complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig4 DNA ligase 4 part_of ISO
IBA		 (PMID:9809069)
GO_REF:0000033		 RGD
GO_Central		 PMID:9809069 GO_REF:0000033 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 part_of ISO
IBA		 (PMID:9242410)
GO_REF:0000033		 RGD
GO_Central		 PMID:9242410 GO_REF:0000033 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
DNA-dependent protein kinase-DNA ligase 4 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig4 DNA ligase 4 part_of ISO
IBA		 (PMID:15194694), (PMID:34352203)
GO_REF:0000033		 RGD
GO_Central		 PMID:15194694 PMID:34352203 GO_REF:0000033 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 part_of IEA
ISO
ISS		 GO_REF:0000107
(PMID:34352203)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:34352203 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit part_of ISO (PMID:15194694), (PMID:34352203) RGD PMID:15194694 PMID:34352203 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 part_of ISO
IBA		 (PMID:15194694), (PMID:34352203)
GO_REF:0000033		 RGD
GO_Central		 PMID:15194694 PMID:34352203 GO_REF:0000033 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 part_of TAS
ISO		 (PMID:34352203) RGD PMID:34352203 PMID:11966321 RGD:727219 NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 part_of ISO (PMID:34352203) RGD PMID:34352203 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20833
    protein-containing complex 6558
      intracellular protein-containing complex 989
        nonhomologous end joining complex 8
          DNA ligase IV complex 3
          DNA-dependent protein kinase-DNA ligase 4 complex 6
          Ku-DNA ligase complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20833
    protein-containing complex 6558
      catalytic complex 1863
        DNA repair complex 23
          nonhomologous end joining complex 8
            DNA ligase IV complex 3
            DNA-dependent protein kinase-DNA ligase 4 complex 6
            Ku-DNA ligase complex 0
paths to the root