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ONTOLOGY REPORT - ANNOTATIONS


Term:ATG2-ATG18 complex
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Accession:GO:0062079 term browser browse the term
Definition:A protein complex essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. Composed of ATG2 and ATG18 in Saccharomyces cerevisiae.



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  cellular_component 21322
    protein-containing complex 6790
      membrane protein complex 1432
        ATG2-ATG18 complex 0
Path 2
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  cellular_component 21322
    cellular anatomical structure 21027
      intracellular anatomical structure 15548
        cytoplasm 12255
          phagophore assembly site 39
            phagophore assembly site membrane 21
              ATG2-ATG18 complex 0
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