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ONTOLOGY REPORT - ANNOTATIONS

Term:autophagosome-lysosome fusion
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Accession:GO:0061909 term browser browse the term
Definition:The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome.
Synonyms:exact_synonym: autophagosome fusion;   autophagosome-vacuole fusion


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autophagosome-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl8b ARF like GTPase 8B involved_in ISO
IEA
ISS		 (PMID:28325809)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28325809 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:141,748,634...141,792,605
Ensembl chr 4:141,748,587...141,792,596 		JBrowse link
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO
IEA
IBA		 (PMID:30538141)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:30538141 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:158,575,727...158,595,157
Ensembl chr 5:153,292,751...153,312,139 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO
IEA		 (PMID:26450516)
GO_REF:0000107		 RGD
Ensembl		 PMID:26450516 GO_REF:0000107 NCBI chr 1:190,586,649...190,600,034
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Diaph3 diaphanous-related formin 3 acts_upstream_of_or_within ISO
IEA		 (PMID:33036023)
GO_REF:0000107		 RGD
Ensembl		 PMID:33036023 GO_REF:0000107 NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975 		JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:29727621)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:29727621 GO_REF:0000024 GO_REF:0000107 NCBI chr17:86,405,080...86,576,597
Ensembl chr17:81,496,670...81,668,029 		JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:29727621)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:29727621 GO_REF:0000024 GO_REF:0000107 NCBI chr10:83,202,379...83,231,292
Ensembl chr10:82,701,098...82,734,938 		JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 involved_in ISO
ISS		 (PMID:28325809)
GO_REF:0000024		 RGD
UniProt		 PMID:28325809 GO_REF:0000024 NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412 		JBrowse link
G Rab2a RAB2A, member RAS oncogene family involved_in ISS
ISO		 GO_REF:0000024
(PMID:37821429)		 UniProt
RGD		 PMID:37821429 GO_REF:0000024 NCBI chr 5:21,676,017...21,740,035
Ensembl chr 5:21,676,129...21,739,899 		JBrowse link
G Rab39a RAB39A, member RAS oncogene family involved_in ISO (PMID:37821429) RGD PMID:37821429 NCBI chr 8:54,088,246...54,105,867
Ensembl chr 8:54,088,129...54,106,483 		JBrowse link
G RGD1359108 similar to RIKEN cDNA 3110043O21 involved_in ISS
ISO		 GO_REF:0000024
(PMID:37821429)		 UniProt
RGD		 PMID:37821429 GO_REF:0000024 NCBI chr 5:54,562,570...54,587,649
Ensembl chr 5:49,766,325...49,791,408 		JBrowse link
G Rubcnl rubicon like autophagy enhancer involved_in ISO
IEA
IBA		 (PMID:28306502)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:28306502 GO_REF:0000033 GO_REF:0000107 NCBI chr15:50,332,458...50,377,494
Ensembl chr15:50,332,418...50,400,849 		JBrowse link
G Stx17 syntaxin 17 involved_in ISS
ISO		 GO_REF:0000024
(PMID:37821429)		 UniProt
RGD		 PMID:37821429 GO_REF:0000024 NCBI chr 5:62,446,138...62,506,108
Ensembl chr 5:62,446,187...62,504,451 		JBrowse link
G Tom1 target of myb1 membrane trafficking protein involved_in ISO
IEA		 (PMID:23023224)
GO_REF:0000107		 RGD
Ensembl		 PMID:23023224 GO_REF:0000107 NCBI chr19:13,405,482...13,440,384
Ensembl chr19:13,405,501...13,440,384 		JBrowse link
G Vps39 VPS39 subunit of HOPS complex involved_in ISO
IEA		 (PMID:33422265)
GO_REF:0000107		 RGD
Ensembl		 PMID:33422265 GO_REF:0000107 NCBI chr 3:107,266,846...107,304,884
Ensembl chr 3:107,267,310...107,304,975 		JBrowse link
positive regulation of autophagosome-lysosome fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Znrf1 zinc and ring finger 1 involved_in ISO
IEA		 FB:FBgn0029911 (PMID:38360932)
GO_REF:0000107		 RGD
Ensembl		 PMID:38360932 GO_REF:0000107 NCBI chr19:56,403,816...56,490,901
Ensembl chr19:39,496,527...39,580,969 		JBrowse link
G Znrf2 zinc and ring finger 2 involved_in ISO FB:FBgn0029911 (PMID:38360932) RGD PMID:38360932 NCBI chr 4:85,274,626...85,358,083
Ensembl chr 4:83,949,309...84,027,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      vesicle-mediated transport 1654
        vesicle fusion 128
          autophagosome-lysosome fusion 16
            positive regulation of autophagosome-lysosome fusion 2
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      cellular component organization or biogenesis 7104
        cellular component organization 6817
          organelle organization 3713
            organelle fusion 180
              organelle membrane fusion 133
                vesicle fusion 128
                  autophagosome-lysosome fusion 16
                    positive regulation of autophagosome-lysosome fusion 2
paths to the root