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ONTOLOGY REPORT - ANNOTATIONS


Term:chaperone-mediated autophagy
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Accession:GO:0061684 term browser browse the term
Definition:The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.
Synonyms:exact_synonym: CASA;   chaperone-assisted selective autophagy
 related_synonym: CMA
 xref: Reactome:R-HSA-9613829 "Chaperone Mediated Autophagy";   Wikipedia:Chaperone-mediated_autophagy



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chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in NAS PMID:18644871 ParkinsonsUK-UCL PMID:18644871 RGD:10412301 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 involved_in NAS PMID:18644871 ParkinsonsUK-UCL PMID:18644871 RGD:10412301 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in
acts_upstream_of_or_within
IDA
IGI
PMID:18644871 ParkinsonsUK-UCL
MGI
PMID:18644871 PMID:18644871 RGD:10412301, RGD:10412301 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in
acts_upstream_of_or_within
IDA
ISO
PMID:11082038
UniProtKB:P13473 (PMID:18644871), (PMID:27628032)
(PMID:18579532)
(PMID:36586411)
(PMID:24880125), (PMID:27628032)
(PMID:8662539)
RGD PMID:8662539 PMID:18579532 PMID:18644871 PMID:24880125 PMID:27628032 More... RGD:1581607 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Synpo2 synaptopodin 2 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr 2:211,217,099...211,371,267
Ensembl chr 2:211,216,783...211,371,267
JBrowse link
negative regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsa cathepsin A involved_in ISO UniProtKB:P10619 (PMID:12505983) RGD PMID:12505983 NCBI chr 3:173,988,443...173,994,320
Ensembl chr 3:153,568,381...153,576,215
JBrowse link
G Snca synuclein alpha involved_in ISO
IEA
(PMID:20697033)
GO_REF:0000107
RGD
Ensembl
PMID:20697033 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
positive regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo-like kinase 3 involved_in ISO (PMID:27344333) RGD PMID:27344333 NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
protein targeting to lysosome involved in chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clu clusterin involved_in ISO
IEA
(PMID:9228033)
GO_REF:0000107
RGD
Ensembl
PMID:9228033 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in ISS
ISO
GO_REF:0000024
(PMID:11559757), (PMID:26212789), (PMID:36586411)
UniProt
RGD
PMID:11559757 PMID:26212789 PMID:36586411 GO_REF:0000024 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in
acts_upstream_of_or_within
ISO
IBA
IEA
IGI
IMP
ISS
(PMID:27628032)
GO_REF:0000033
GO_REF:0000107
PMID:18644871
GO_REF:0000024
RGD
GO_Central
Ensembl
UniProt
PMID:27628032 PMID:18644871 PMID:18644871 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:10412301, RGD:10412301 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfap glial fibrillary acidic protein involved_in ISO
IMP
IBA
(PMID:20797626)
GO_REF:0000033
RGD
GO_Central
PMID:20797626 PMID:20797626 GO_REF:0000033, RGD:10412296 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      process utilizing autophagic mechanism 555
        autophagy 555
          chaperone-mediated autophagy 12
            chaperone-mediated autophagy translocation complex assembly 0
            negative regulation of chaperone-mediated autophagy 2
            positive regulation of chaperone-mediated autophagy 1
            protein targeting to lysosome involved in chaperone-mediated autophagy 3
            regulation of chaperone-mediated autophagy + 4
Path 2
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      metabolic process 12160
        catabolic process 2919
          macromolecule catabolic process 1678
            protein catabolic process 1199
              chaperone-mediated autophagy 12
                chaperone-mediated autophagy translocation complex assembly 0
                negative regulation of chaperone-mediated autophagy 2
                positive regulation of chaperone-mediated autophagy 1
                protein targeting to lysosome involved in chaperone-mediated autophagy 3
                regulation of chaperone-mediated autophagy + 4
paths to the root