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ONTOLOGY REPORT - ANNOTATIONS

Term:3-demethylubiquinol 3-O-methyltransferase activity
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Accession:GO:0061542 term browser browse the term
Definition:Catalysis of the reaction: a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H+.
Comment:Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
Synonyms:exact_synonym: 3-demethylubiquinol-n 3-O-methyltransferase activity
 narrow_synonym: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase;   5-demethylubiquinone-10 methyltransferase;   5-demethylubiquinone-9 methyltransferase
 related_synonym: OMHMB-methyltransferase;   S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase
 xref: EC:2.1.1.64;   RHEA:44380;   Reactome:R-HSA-2162186 "COQ3 methylates DeMQ10H2"


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3-demethylubiquinol 3-O-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coq3 coenzyme Q3 methyltransferase enables ISO
IBA
IEA		 (PMID:10777520)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
GO_REF:0000003
GO_REF:0000104		 RGD
GO_Central
Ensembl
InterPro
UniProt		 PMID:10777520 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 5:40,226,313...40,257,383
Ensembl chr 5:35,429,574...35,460,607 		JBrowse link
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  molecular_function 21100
    catalytic activity 6213
      transferase activity 2476
        transferase activity, transferring one-carbon groups 215
          methyltransferase activity 204
            S-adenosylmethionine-dependent methyltransferase activity 170
              3-demethylubiquinol 3-O-methyltransferase activity 1
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