Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cartilage development
go back to main search page
Accession:GO:0061037 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


show annotations for term's descendants           Sort by:
negative regulation of cartilage development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsk cathepsin K acts_upstream_of_or_within ISO MGI:2182131 (PMID:19834056) RGD PMID:19834056 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Frzb frizzled-related protein acts_upstream_of_or_within ISO MGI:98958 (PMID:18991062) RGD PMID:18991062 NCBI chr 3:85,739,162...85,772,168
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236 (PMID:19834056) RGD PMID:19834056 NCBI chr14:1,175,994...1,203,913
Ensembl chr14:1,032,171...1,046,522 		JBrowse link
G Lep leptin IDA RGD PMID:19876764 RGD:5128612 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:24577233) RGD PMID:24577233 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Nog noggin involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:10684250)		 Ensembl
RGD		 PMID:10684250 GO_REF:0000107 NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Rara retinoic acid receptor, alpha acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rarb retinoic acid receptor, beta acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rarg retinoic acid receptor, gamma acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of_or_within ISO MGI:1888389 (PMID:21780244) RGD PMID:21780244 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Wnt9a Wnt family member 9A acts_upstream_of_or_within ISO (PMID:19047045) RGD PMID:19047045 NCBI chr10:44,593,691...44,620,682
Ensembl chr10:44,094,140...44,121,133 		JBrowse link
negative regulation of chondrocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:90087)
GO_REF:0000107		 RGD
Ensembl		 PMID:90087 GO_REF:0000107 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Rflna refilin A involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1923816 (PMID:24436304)		 GO_Central
RGD		 PMID:24436304 GO_REF:0000033 NCBI chr12:37,294,643...37,323,373
Ensembl chr12:31,633,361...31,642,317 		JBrowse link
G Rflnb refilin B involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1920371 (PMID:24436304)		 GO_Central
RGD		 PMID:24436304 GO_REF:0000033 NCBI chr10:61,391,947...61,398,224
Ensembl chr10:60,893,713...60,899,976 		JBrowse link
negative regulation of chondrocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 involved_in ISO (PMID:22247065) RGD PMID:22247065 NCBI chr 2:61,759,975...62,054,716
Ensembl chr 2:60,032,873...60,327,629 		JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 involved_in ISO (PMID:22247065) RGD PMID:22247065 NCBI chr 8:99,584,529...99,624,132
Ensembl chr 8:90,704,727...90,744,328 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17481601)		 Ensembl
RGD		 PMID:17481601 GO_REF:0000107 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Ccn4 cellular communication network factor 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15331410)		 Ensembl
RGD		 PMID:15331410 GO_REF:0000107 NCBI chr 7:100,534,578...100,566,287
Ensembl chr 7:98,645,182...98,677,248 		JBrowse link
G Chadl chondroadherin-like involved_in ISO (PMID:25451920) RGD PMID:25451920 NCBI chr 7:115,085,447...115,097,565
Ensembl chr 7:113,210,748...113,217,272 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2148591|MGI:2148594|MGI:2446084|MGI:2450929 (PMID:15866163), (PMID:16818445)		 Ensembl
RGD		 PMID:15866163 PMID:16818445 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 involved_in ISO
IEA
ISS		 (PMID:20005202)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20005202 GO_REF:0000024 GO_REF:0000107 NCBI chr14:106,811,769...106,890,961
Ensembl chr14:102,610,908...102,690,018 		JBrowse link
G Gdf5 growth differentiation factor 5 involved_in ISO (PMID:21976273) RGD PMID:21976273 NCBI chr 3:164,914,401...164,918,593
Ensembl chr 3:144,454,338...144,458,612 		JBrowse link
G Gli2 GLI family zinc finger 2 acts_upstream_of_or_within ISO MGI:1857509 (PMID:17328886) RGD PMID:17328886 NCBI chr13:32,499,678...32,716,418
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 acts_upstream_of_or_within ISO MGI:96533 (PMID:16284117) RGD PMID:16284117 NCBI chr17:54,134,064...54,405,198
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:10556075) RGD PMID:10556075 NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Ihh Indian hedgehog signaling molecule acts_upstream_of_or_within ISO MGI:1934258 (PMID:16284117) RGD PMID:16284117 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (PMID:11790802) RGD PMID:11790802 NCBI chr 1:212,458,362...212,475,302
Ensembl chr 1:203,029,877...203,045,975 		JBrowse link
G Mkx mohawk homeobox IMP RGD PMID:27370800 RGD:40924660 NCBI chr17:59,772,113...59,851,160
Ensembl chr17:55,077,540...55,156,124 		JBrowse link
G Nkx3-2 NK3 homeobox 2 involved_in ISO (PMID:16421188) RGD PMID:16421188 NCBI chr14:73,396,198...73,398,585
Ensembl chr14:69,183,820...69,186,061 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:36905926)		 UniProt
RGD		 PMID:36905926 GO_REF:0000024 NCBI chr13:50,865,253...50,985,107
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Pth parathyroid hormone involved_in IMP PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within ISO (PMID:90087)
MGI:2154515|MGI:95728 (PMID:17328886), (PMID:8895385)		 RGD PMID:90087 PMID:8895385 PMID:17328886 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:29644115)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:29644115 GO_REF:0000024 GO_REF:0000107 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rarb retinoic acid receptor, beta acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rarg retinoic acid receptor, gamma acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:19756381) RGD PMID:19756381 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2158693 (PMID:11371614)		 UniProt
RGD		 PMID:11371614 GO_REF:0000024 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19494318)		 Ensembl
RGD		 PMID:19494318 GO_REF:0000107 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Wnt9a Wnt family member 9A acts_upstream_of_or_within ISO MGI:3701350|MGI:88276 (PMID:16818445) RGD PMID:16818445 NCBI chr10:44,593,691...44,620,682
Ensembl chr10:44,094,140...44,121,133 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    negative regulation of biological process 5818
      negative regulation of multicellular organismal process 1358
        negative regulation of cartilage development 35
          negative regulation of chondrocyte differentiation + 27
Path 2
Term Annotations click to browse term
  biological_process 20546
    developmental process 7139
      anatomical structure development 6638
        multicellular organism development 5350
          system development 4630
            skeletal system development 590
              cartilage development 238
                regulation of cartilage development 76
                  negative regulation of cartilage development 35
                    negative regulation of chondrocyte differentiation + 27
paths to the root