Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:long-term synaptic depression
go back to main search page
Accession:GO:0060292 term browser browse the term
Definition:A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
Synonyms:broad_synonym: long term depression
 related_synonym: LTD


show annotations for term's descendants           Sort by:
long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD6 abhydrolase domain containing 6, acylglycerol lipase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20657592) Ensembl
MGI		 PMID:20657592 GO_REF:0000107 NCBI chr13:39,982,536...40,055,467
Ensembl chr13:40,009,737...40,060,394 		JBrowse link
G ADORA1 adenosine A1 receptor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:24259587) Ensembl
MGI		 PMID:24259587 GO_REF:0000107 NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,921...113,872,365 		JBrowse link
G ARF1 ADP ribosylation factor 1 involved_in ISO PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr 2:51,219,597...51,237,640
Ensembl chr 2:51,219,667...51,237,639 		JBrowse link
G CD38 CD38 molecule ISO RGD PMID:10097163 RGD:2307271 NCBI chr 8:11,083,682...11,130,783
Ensembl chr 8:11,083,682...11,130,756 		JBrowse link
G DRD1 dopamine receptor D1 acts_upstream_of_or_within ISO (PMID:14981263) MGI PMID:14981263 NCBI chr16:49,189,555...49,193,722
Ensembl chr16:49,189,602...49,191,976 		JBrowse link
G DRD5 dopamine receptor D5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:13679419) Ensembl
MGI		 PMID:13679419 GO_REF:0000107 NCBI chr 8:6,180,221...6,182,575
Ensembl chr 8:6,180,221...6,181,636 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24259587) Ensembl
MGI		 PMID:24259587 GO_REF:0000107 NCBI chr16:69,332,786...69,654,366
Ensembl chr16:69,332,587...69,655,380 		JBrowse link
G GRID2IP Grid2 interacting protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18509461) Ensembl
MGI		 PMID:18509461 GO_REF:0000107 NCBI chr 3:4,667,282...4,699,821
Ensembl chr 3:4,667,916...4,700,037 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8662555) Ensembl
MGI		 PMID:8662555 GO_REF:0000107 NCBI chr13:33,924,303...33,938,279
Ensembl chr13:33,926,804...33,938,269 		JBrowse link
G MGLL monoglyceride lipase acts_upstream_of_or_within ISO (PMID:20657592) MGI PMID:20657592 NCBI chr13:72,480,395...72,568,964
Ensembl chr13:72,480,174...72,568,961 		JBrowse link
G PICK1 protein interacting with PRKCA 1 involved_in ISO PMID:21252856 UniProt PMID:21252856 RGD:8554238 NCBI chr 5:9,808,444...9,829,677
Ensembl chr 5:9,808,451...9,825,539 		JBrowse link
G PLK2 polo like kinase 2 involved_in ISO PMID:21382555 UniProt PMID:21382555 RGD:7241548 NCBI chr16:37,299,116...37,305,114
Ensembl chr16:37,299,119...37,305,114 		JBrowse link
G PRRT1 proline rich transmembrane protein 1 involved_in ISO (PMID:31216424) UniProt PMID:31216424 NCBI chr 7:24,183,557...24,186,892
Ensembl chr 7:24,180,637...24,186,908 		JBrowse link
G PTEN phosphatase and tensin homolog ISO NMDA receptor-dependent RGD PMID:20628354 RGD:4144068 NCBI chr14:99,929,590...100,021,619 JBrowse link
G PTK2B protein tyrosine kinase 2 beta ISO RGD PMID:20826662 RGD:10041066 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192 		JBrowse link
G SHANK2 SH3 and multiple ankyrin repeat domains 2 involved_in ISO (PMID:22699620) BHF-UCL PMID:22699620 NCBI chr 2:2,517,853...3,016,959
Ensembl chr 2:2,864,331...3,015,314 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 involved_in ISO (PMID:21795692) CACAO PMID:21795692 NCBI chr 5:41,376...93,033
Ensembl chr 5:41,786...93,177 		JBrowse link
G SLC24A1 solute carrier family 24 member 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:163,603,223...163,662,071
Ensembl chr 1:163,604,594...163,658,318 		JBrowse link
G SLC24A2 solute carrier family 24 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:16407245) Ensembl
MGI
GO_Central		 PMID:16407245 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:203,059,563...203,336,442
Ensembl chr 1:203,059,588...203,333,781 		JBrowse link
G SORCS2 sortilin related VPS10 domain containing receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:3,207,087...3,715,002
Ensembl chr 8:3,207,098...3,760,393 		JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16600861) Ensembl
MGI		 PMID:16600861 GO_REF:0000107 NCBI chr 7:38,213,300...38,223,686
Ensembl chr 7:38,213,487...38,222,144 		JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17110441) Ensembl
MGI		 PMID:17110441 GO_REF:0000107 NCBI chr 1:268,116,124...268,205,805
Ensembl chr 1:268,116,120...268,205,778 		JBrowse link
G VPS13A vacuolar protein sorting 13 homolog A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:37714309) MGI
Ensembl		 PMID:37714309 GO_REF:0000107 NCBI chr 1:230,069,339...230,331,343
Ensembl chr 1:230,069,368...230,331,200 		JBrowse link
negative regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24259587) Ensembl
MGI		 PMID:24259587 GO_REF:0000107 NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,921...113,872,365 		JBrowse link
G AGER advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G FMR1 Fragile X messenger ribonucleoprotein 1 involved_in ISO (PMID:11438589) UniProt PMID:11438589 NCBI chr  X:120,361,232...120,400,282
Ensembl chr  X:120,361,367...120,399,831 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:19437411 RGD:408345242 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451 		JBrowse link
positive regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY8 adenylate cyclase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:9,645,398...9,867,065
Ensembl chr 4:9,645,659...9,866,550 		JBrowse link
G CBLN1 cerebellin 1 precursor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:35,516,097...35,518,080
Ensembl chr 6:35,515,754...35,519,517 		JBrowse link
G FMR1 Fragile X messenger ribonucleoprotein 1 ISO RGD PMID:28894415 RGD:38501107 NCBI chr  X:120,361,232...120,400,282
Ensembl chr  X:120,361,367...120,399,831 		JBrowse link
G GRID2 glutamate ionotropic receptor delta type subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:125,821,195...127,130,617
Ensembl chr 8:125,819,951...127,129,763 		JBrowse link
G IQSEC2 IQ motif and Sec7 domain ArfGEF 2 ISO RGD PMID:27009485 RGD:11049506 NCBI chr  X:46,011,386...46,094,978
Ensembl chr  X:46,011,388...46,094,817 		JBrowse link
G KCNB1 potassium voltage-gated channel subfamily B member 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:51,032,163...51,152,566
Ensembl chr17:51,039,987...51,142,644 		JBrowse link
G MAPT microtubule associated protein tau ISO RGD PMID:24298146 RGD:10412705 NCBI chr12:17,098,259...17,211,483
Ensembl chr12:17,095,587...17,211,373 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO RGD PMID:31329835 RGD:597015744 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882 		JBrowse link
G PPP1R9A protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:16899074 RGD:10002752 NCBI chr 9:74,635,285...74,944,050
Ensembl chr 9:74,635,403...74,940,362 		JBrowse link
G STAU2 staufen double-stranded RNA binding protein 2 ISO RGD PMID:21508097 RGD:10043164 NCBI chr 4:62,139,456...62,455,509
Ensembl chr 4:62,139,464...62,455,499 		JBrowse link
regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARC activity regulated cytoskeleton associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:1,517,986...1,521,403
Ensembl chr 4:1,518,180...1,519,370 		JBrowse link
G BCL2L1 BCL2 like 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO RGD PMID:21187978 RGD:596933102 NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,467,835...56,492,602 		JBrowse link
G DGKI diacylglycerol kinase iota involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21119615) Ensembl
MGI		 PMID:21119615 GO_REF:0000107 NCBI chr18:11,705,055...12,187,098
Ensembl chr18:11,705,093...12,177,267 		JBrowse link
G GNAL G protein subunit alpha L ISO RGD PMID:31678405 RGD:150429833 NCBI chr 6:97,342,468...97,429,334
Ensembl chr 6:97,342,474...97,429,364 		JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 ISO RGD PMID:16311338 PMID:21187978 PMID:37190555 RGD:596933067 RGD:596933068 RGD:596933102 NCBI chr 8:46,078,122...46,247,144
Ensembl chr 8:46,078,276...46,241,914 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:21187978 RGD:596933102 NCBI chr 5:58,477,862...58,948,735
Ensembl chr 5:58,480,528...58,927,558 		JBrowse link
G PENK proenkephalin involved_in ISO (PMID:35201898) UniProt PMID:35201898 NCBI chr 4:75,525,497...75,530,403
Ensembl chr 4:75,525,555...75,530,876 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 involved_in ISO (PMID:21795692) BHF-UCL PMID:21795692 NCBI chr 5:41,376...93,033
Ensembl chr 5:41,786...93,177 		JBrowse link
G SORCS3 sortilin related VPS10 domain containing receptor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24069373) Ensembl
MGI		 PMID:24069373 GO_REF:0000107 NCBI chr14:115,587,176...116,202,433
Ensembl chr14:115,587,821...116,198,106 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18943
    negative regulation of biological process 5645
      negative regulation of signaling 1607
        negative regulation of synaptic transmission 78
          long-term synaptic depression 44
            negative regulation of long-term synaptic depression 4
            positive regulation of long-term synaptic depression 10
            regulation of long-term synaptic depression + 23
Path 2
Term Annotations click to browse term
  biological_process 18943
    biological regulation 13022
      regulation of biological process 12639
        signaling 7545
          cell-cell signaling 1431
            synaptic signaling 958
              trans-synaptic signaling 920
                anterograde trans-synaptic signaling 912
                  chemical synaptic transmission 912
                    modulation of chemical synaptic transmission 710
                      negative regulation of synaptic transmission 78
                        long-term synaptic depression 44
                          negative regulation of long-term synaptic depression 4
                          positive regulation of long-term synaptic depression 10
                          regulation of long-term synaptic depression + 23
paths to the root