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ONTOLOGY REPORT - ANNOTATIONS

Term:long-term synaptic depression
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Accession:GO:0060292 term browser browse the term
Definition:A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
Synonyms:broad_synonym: long term depression
 related_synonym: LTD


show annotations for term's descendants           Sort by:
long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase acts_upstream_of_or_within ISO (PMID:20657592) RGD PMID:20657592 NCBI chr15:16,859,740...16,907,094
Ensembl chr15:16,859,738...16,906,985 		JBrowse link
G Adora1 adenosine A1 receptor acts_upstream_of ISO MGI:95808 (PMID:24259587) RGD PMID:24259587 NCBI chr13:48,210,922...48,247,826
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Arf1 ARF GTPase 1 involved_in IDA PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Cd38 CD38 molecule IMP RGD PMID:10097163 RGD:2307271 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857158 (PMID:14981263)		 Ensembl
RGD		 PMID:14981263 GO_REF:0000107 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd5 dopamine receptor D5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:13679419)		 Ensembl
RGD		 PMID:13679419 GO_REF:0000107 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:99401 (PMID:24259587)		 Ensembl
RGD		 PMID:24259587 GO_REF:0000107 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grid2ip Grid2 interacting protein acts_upstream_of_or_within ISO MGI:3796575 (PMID:18509461) RGD PMID:18509461 NCBI chr12:11,166,567...11,203,765
Ensembl chr12:11,167,874...11,203,676 		JBrowse link
G Grm2 glutamate metabotropic receptor 2 acts_upstream_of_or_within ISO MGI:1857988 (PMID:8662555) RGD PMID:8662555 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Mgll monoglyceride lipase acts_upstream_of_or_within ISO (PMID:20657592) RGD PMID:20657592 NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179 		JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IDA PMID:21252856 UniProt PMID:21252856 RGD:8554238 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
G Plk2 polo-like kinase 2 involved_in IDA PMID:21382555 UniProt PMID:21382555 RGD:7241548 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Prrt1 proline-rich transmembrane protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:31216424)		 UniProt
RGD		 PMID:31216424 GO_REF:0000024 NCBI chr20:4,117,957...4,121,643
Ensembl chr20:4,117,957...4,121,600 		JBrowse link
G Pten phosphatase and tensin homolog IMP NMDA receptor-dependent RGD PMID:20628354 RGD:4144068 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:20826662 RGD:10041066 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:22699620)		 BHF-UCL
RGD		 PMID:22699620 GO_REF:0000024 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21795692)		 Ensembl
RGD		 PMID:21795692 GO_REF:0000107 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Slc24a1 solute carrier family 24 member 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:65,440,842...65,466,001
Ensembl chr 8:65,440,730...65,466,001 		JBrowse link
G Slc24a2 solute carrier family 24 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:3663782 (PMID:16407245)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:16407245 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:101,497,916...101,741,840
Ensembl chr 5:101,502,278...101,739,337 		JBrowse link
G Sorcs2 sortilin-related VPS10 domain containing receptor 2 involved_in ISO (PMID:27457814) RGD PMID:27457814 NCBI chr14:74,371,089...74,735,943
Ensembl chr14:74,371,415...74,735,943 		JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO MGI:2385465|MGI:2678305 (PMID:16600861) RGD PMID:16600861 NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Stxbp1 syntaxin binding protein 1 acts_upstream_of_or_within ISO MGI:2183278 (PMID:17110441) RGD PMID:17110441 NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Vps13a vacuolar protein sorting 13 homolog A acts_upstream_of_or_within ISO (PMID:37714309) RGD PMID:37714309 NCBI chr 1:213,901,999...214,128,638
Ensembl chr 1:213,901,999...214,128,555 		JBrowse link
negative regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor acts_upstream_of_or_within ISO MGI:95808 (PMID:24259587) RGD PMID:24259587 NCBI chr13:48,210,922...48,247,826
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA		 ComplexPortal:CPX-1134 (PMID:20739563)
GO_REF:0000107		 RGD
Ensembl		 PMID:20739563 GO_REF:0000107 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:11438589)		 UniProt
RGD		 PMID:11438589 GO_REF:0000024 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:19437411 RGD:408345242 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
positive regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy8 adenylate cyclase 8 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:10864938)		 Ensembl
UniProt
RGD		 PMID:10864938 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:98,306,434...98,555,687
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Cbln1 cerebellin 1 precursor involved_in ISO (PMID:27418511) RGD PMID:27418511 NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 IMP RGD PMID:28894415 RGD:38501107 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 involved_in ISO (PMID:27418511) RGD PMID:27418511 NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355 		JBrowse link
G Iqsec2 IQ motif and Sec7 domain ArfGEF 2 IMP RGD PMID:27009485 RGD:11049506 NCBI chr  X:24,734,202...24,816,566
Ensembl chr  X:21,254,914...21,336,584 		JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24494598)		 UniProt
Ensembl
RGD		 PMID:24494598 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194 		JBrowse link
G Mapt microtubule-associated protein tau IMP RGD PMID:24298146 RGD:10412705 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IMP RGD PMID:31329835 RGD:597015744 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pirb paired Ig-like receptor B involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:24052308) RGD PMID:24052308 NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666 		JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:16899074 RGD:10002752 NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907 		JBrowse link
G Stau2 staufen double-stranded RNA binding protein 2 IMP RGD PMID:21508097 RGD:10043164 NCBI chr 5:7,623,528...7,868,206
Ensembl chr 5:2,840,765...3,084,929 		JBrowse link
regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:29264923)		 UniProt
RGD		 PMID:29264923 GO_REF:0000024 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in IMP PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:21187978 RGD:596933102 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Dgki diacylglycerol kinase, iota involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3584141 (PMID:21119615)		 Ensembl
RGD		 PMID:21119615 GO_REF:0000107 NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733 		JBrowse link
G Gnal G protein subunit alpha L IMP RGD PMID:31678405 RGD:150429833 NCBI chr18:62,892,257...63,032,510
Ensembl chr18:60,622,311...60,762,599 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 IMP RGD PMID:16311338 PMID:21187978 PMID:37190555 RGD:596933067, RGD:596933102, RGD:596933068 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B IMP RGD PMID:21187978 RGD:596933102 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Penk proenkephalin involved_in ISO (PMID:35201898) RGD PMID:35201898 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:21795692)		 Ensembl
RGD		 PMID:21795692 PMID:21795692 GO_REF:0000107, RGD:7349315 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 acts_upstream_of_or_within ISO MGI:5562419 (PMID:24069373) RGD PMID:24069373 NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:247,099,408...247,734,027 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    negative regulation of biological process 5818
      negative regulation of signaling 1652
        negative regulation of synaptic transmission 80
          long-term synaptic depression 45
            negative regulation of long-term synaptic depression 4
            positive regulation of long-term synaptic depression 11
            regulation of long-term synaptic depression + 24
Path 2
Term Annotations click to browse term
  biological_process 20546
    biological regulation 13834
      regulation of biological process 13389
        signaling 7822
          cell-cell signaling 1484
            synaptic signaling 1005
              trans-synaptic signaling 961
                anterograde trans-synaptic signaling 953
                  chemical synaptic transmission 953
                    modulation of chemical synaptic transmission 745
                      negative regulation of synaptic transmission 80
                        long-term synaptic depression 45
                          negative regulation of long-term synaptic depression 4
                          positive regulation of long-term synaptic depression 11
                          regulation of long-term synaptic depression + 24
paths to the root