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ONTOLOGY REPORT - ANNOTATIONS

Term:synapse maturation
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Accession:GO:0060074 term browser browse the term
Definition:The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
Synonyms:exact_synonym: synaptic maturation


show annotations for term's descendants           Sort by:
synapse maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase involved_in ISO (PMID:27335408) RGD PMID:27335408 NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Bcan brevican involved_in IEA
ISO		 GO_REF:0000107
(PMID:28712654)		 Ensembl
RGD		 PMID:28712654 GO_REF:0000107 NCBI chr 2:173,454,479...173,467,717
Ensembl chr 2:173,454,482...173,467,460 		JBrowse link
G Ccdc39 coiled-coil domain 39 molecular ruler complex subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:34992132)
GO_REF:0000107		 RGD
Ensembl		 PMID:34992132 GO_REF:0000107 NCBI chr 2:116,665,651...116,703,354
Ensembl chr 2:116,665,261...116,703,350 		JBrowse link
G Chrdl1 chordin-like 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:6315865 (PMID:30344043)		 Ensembl
RGD		 PMID:30344043 GO_REF:0000107 NCBI chr  X:106,889,125...106,992,937
Ensembl chr  X:106,889,125...106,992,921 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in ISO (PMID:24487234) RGD PMID:24487234 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IMP RGD PMID:17521571 PMID:30206770 RGD:2289990, RGD:405650589 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Igsf21 immunoglobin superfamily, member 21 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28864826)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28864826 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:152,287,834...152,512,174
Ensembl chr 5:152,287,835...152,512,174 		JBrowse link
G Lnx1 ligand of numb-protein X 1 involved_in ISO (PMID:30185604) RGD PMID:30185604 NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 acts_upstream_of ISO (PMID:23407945) RGD PMID:23407945 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nfia nuclear factor I/A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23407945)		 Ensembl
RGD		 PMID:23407945 GO_REF:0000107 NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885 		JBrowse link
G Nlgn1 neuroligin 1 involved_in NAS PMID:16242404 ComplexPortal PMID:16242404 RGD:151356616 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nrxn1 neurexin 1 involved_in NAS PMID:16242404 ComplexPortal PMID:16242404 RGD:151356616 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Palm paralemmin involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:18287537)		 Ensembl
GO_Central
RGD		 PMID:18287537 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,886,634...9,912,389
Ensembl chr 7:9,886,643...9,912,555 		JBrowse link
G Pfn1 profilin 1 involved_in ISO (PMID:26951674) RGD PMID:26951674 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631 		JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:18082964) RGD PMID:18082964 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in ISO (PMID:34686348) RGD PMID:34686348 NCBI chr11:12,528,949...14,096,726
Ensembl chr11:12,528,951...13,041,536 		JBrowse link
G Sez6 seizure related 6 homolog involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1935121|MGI:2385295 (PMID:16814779)		 GO_Central
RGD		 PMID:16814779 GO_REF:0000033 NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671 		JBrowse link
G Sez6l seizure related 6 homolog like involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:104745|MGI:2385295 (PMID:16814779)		 GO_Central
RGD		 PMID:16814779 GO_REF:0000033 NCBI chr12:44,064,901...44,221,814
Ensembl chr12:44,064,935...44,219,663 		JBrowse link
G Sez6l2 seizure related 6 homolog like 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:104745|MGI:1935121 (PMID:16814779)		 GO_Central
RGD		 PMID:16814779 GO_REF:0000033 NCBI chr 1:181,557,109...181,577,456
Ensembl chr 1:181,557,109...181,577,456 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 involved_in IDA PMID:18287537 UniProt PMID:18287537 RGD:8553517 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Slit2 slit guidance ligand 2 involved_in NAS
IMP
IDA		 PMID:34686348 SynGO PMID:34686348 PMID:34686348 PMID:34686348 RGD:405650259, RGD:405650259, RGD:405650259 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Sybu syntabulin involved_in IMP
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:19828815 GO_REF:0000033, RGD:13217418 NCBI chr 7:75,847,000...75,948,919
Ensembl chr 7:75,847,003...75,948,828 		JBrowse link
G Vezt vezatin, adherens junctions transmembrane protein involved_in ISO (PMID:22745500) RGD PMID:22745500 NCBI chr 7:28,512,214...28,597,429
Ensembl chr 7:28,534,249...28,597,356 		JBrowse link
cell-cell adhesion involved in synapse maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlgn1 neuroligin 1 involved_in NAS PMID:16242404 ComplexPortal PMID:16242404 RGD:151356616 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nrxn1 neurexin 1 involved_in NAS PMID:16242404 ComplexPortal PMID:16242404 RGD:151356616 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
negative regulation of synapse maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef15 Rho guanine nucleotide exchange factor 15 involved_in ISO (PMID:21029865) RGD PMID:21029865 NCBI chr10:53,650,521...53,663,269
Ensembl chr10:53,650,553...53,663,913 		JBrowse link
G Neurod2 neuronal differentiation 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19900895)		 UniProt
Ensembl
RGD		 PMID:19900895 GO_REF:0000024 GO_REF:0000107 NCBI chr10:83,323,801...83,327,986
Ensembl chr10:83,324,442...83,327,986 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 acts_upstream_of_or_within ISO (PMID:23407945) RGD PMID:23407945 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
positive regulation of synapse maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc2 anaphase promoting complex subunit 2 involved_in ISO (PMID:19900895) RGD PMID:19900895 NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta involved_in IMP PMID:12873385 UniProt PMID:12873385 RGD:8553829 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Cdc20 cell division cycle 20 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19900895)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19900895 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:23326475)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23326475 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K IMP RGD PMID:22102872 RGD:10002783 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 involved_in ISO (PMID:22153079) RGD PMID:22153079 NCBI chr 1:246,066,830...246,152,890
Ensembl chr 1:246,067,100...246,152,903 		JBrowse link
G Neurod2 neuronal differentiation 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16504944)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16504944 GO_REF:0000024 GO_REF:0000107 NCBI chr10:83,323,801...83,327,986
Ensembl chr10:83,324,442...83,327,986 		JBrowse link
G Nrxn1 neurexin 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 GO_REF:0000024
(PMID:19567877)
GO_REF:0000107		 BHF-UCL
RGD
Ensembl		 PMID:19567877 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Reln reelin involved_in IEA
ISO		 GO_REF:0000107
(PMID:17229826)		 Ensembl
RGD		 PMID:17229826 GO_REF:0000107 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
protein-containing complex assembly involved in synapse maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrxn1 neurexin 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:12796785)		 BHF-UCL
RGD		 PMID:12796785 GO_REF:0000024 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
regulation of synapse maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb3 adhesion G protein-coupled receptor B3 involved_in ISO (PMID:25611509) RGD PMID:25611509 NCBI chr 9:27,421,168...28,148,979
Ensembl chr 9:27,421,168...28,148,855 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in ISO
IEA		 (PMID:29735530)
GO_REF:0000107		 RGD
Ensembl		 PMID:29735530 GO_REF:0000107 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G C1ql2 complement C1q like 2 involved_in ISO (PMID:25611509) RGD PMID:25611509 NCBI chr13:31,471,150...31,472,685
Ensembl chr13:31,471,150...31,472,689 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta involved_in IDA
IEP
IMP		 PMID:17404223 SynGO PMID:17404223 PMID:17404223 PMID:17404223 RGD:13432239, RGD:13432239, RGD:13432239 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Clstn1 calsyntenin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24966372)		 Ensembl
RGD		 PMID:24966372 GO_REF:0000107 NCBI chr 5:160,031,235...160,094,585
Ensembl chr 5:160,031,308...160,094,583 		JBrowse link
G Cntnap1 contactin associated protein 1 involved_in ISO (PMID:33148880) RGD PMID:33148880 NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611 		JBrowse link
G Dab1 DAB adaptor protein 1 involved_in ISO
IEA		 (PMID:27624722)
GO_REF:0000107		 RGD
Ensembl		 PMID:27624722 GO_REF:0000107 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552 		JBrowse link
G Disc1 DISC1 scaffold protein involved_in ISO (PMID:17825401) RGD PMID:17825401 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778 		JBrowse link
G Dlgap4 DLG associated protein 4 involved_in ISO
IEA		 (PMID:30664629)
GO_REF:0000107		 RGD
Ensembl		 PMID:30664629 GO_REF:0000107 NCBI chr 3:145,124,189...145,271,791
Ensembl chr 3:145,175,479...145,270,490 		JBrowse link
G Fgf22 fibroblast growth factor 22 involved_in ISO (PMID:20505669), (PMID:27627962) RGD PMID:20505669 PMID:27627962 NCBI chr 7:9,947,632...9,956,918
Ensembl chr 7:9,948,071...9,950,486 		JBrowse link
G Fgf7 fibroblast growth factor 7 involved_in ISO
IEA		 (PMID:20505669)
GO_REF:0000107		 RGD
Ensembl		 PMID:20505669 GO_REF:0000107 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Igsf9 immunoglobulin superfamily, member 9 involved_in IMP
IDA		 PMID:15340156 SynGO PMID:15340156 PMID:15340156 RGD:405650278, RGD:405650278 NCBI chr13:84,948,643...84,965,616
Ensembl chr13:84,948,619...84,965,607 		JBrowse link
G Mdga1 MAM domain containing glycosylphosphatidylinositol anchor 1 involved_in IDA
IMP		 PMID:35532105 SynGO PMID:35532105 PMID:35532105 RGD:405650385, RGD:405650385 NCBI chr20:7,900,327...7,964,309
Ensembl chr20:7,904,358...7,963,471 		JBrowse link
G Mdga2 MAM domain containing glycosylphosphatidylinositol anchor 2 involved_in IDA
IMP		 PMID:35532105 SynGO PMID:35532105 PMID:35532105 RGD:405650385, RGD:405650385 NCBI chr 6:84,746,422...85,608,640
Ensembl chr 6:84,761,941...85,608,126 		JBrowse link
G Nefl neurofilament light chain involved_in ISO (PMID:25232125) RGD PMID:25232125 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nrg2 neuregulin 2 involved_in IDA
IMP		 PMID:26674872 SynGO PMID:26674872 PMID:26674872 RGD:11070025, RGD:11070025 NCBI chr18:27,616,542...27,798,505
Ensembl chr18:27,619,661...27,798,505 		JBrowse link
G Nrn1 neuritin 1 involved_in ISO (PMID:22190461) RGD PMID:22190461 NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896 		JBrowse link
G Reln reelin involved_in ISO (PMID:27624722) RGD PMID:27624722 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:30826947)		 Ensembl
RGD		 PMID:30826947 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:30826947) RGD PMID:30826947 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Sdc2 syndecan 2 involved_in IMP
IDA		 PMID:9971750 SynGO PMID:9971750 PMID:9971750 RGD:405650346, RGD:405650346 NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081 		JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) involved_in ISO (PMID:25201975) RGD PMID:25201975 NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536 		JBrowse link
G Snx27 sorting nexin 27 involved_in ISO
IEA		 (PMID:33330482)
GO_REF:0000107		 RGD
Ensembl		 PMID:33330482 GO_REF:0000107 NCBI chr 2:182,135,904...182,218,906
Ensembl chr 2:182,135,905...182,218,906 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26521016) RGD PMID:26521016 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta involved_in ISO
IEA		 (PMID:16959763)
GO_REF:0000107		 RGD
Ensembl		 PMID:16959763 GO_REF:0000107 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20537
    developmental process 7105
      developmental maturation 420
        synapse maturation 55
          cell-cell adhesion involved in synapse maturation 2
          negative regulation of synapse maturation 3
          positive regulation of synapse maturation + 9
          protein-containing complex assembly involved in synapse maturation 1
          regulation of synapse maturation + 34
Path 2
Term Annotations click to browse term
  biological_process 20537
    cellular process 19526
      cellular component organization or biogenesis 7187
        cellular component organization 6903
          cell junction organization 985
            synapse organization 705
              synapse maturation 55
                cell-cell adhesion involved in synapse maturation 2
                negative regulation of synapse maturation 3
                positive regulation of synapse maturation + 9
                protein-containing complex assembly involved in synapse maturation 1
                regulation of synapse maturation + 34
paths to the root