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ONTOLOGY REPORT - ANNOTATIONS

Term:all-trans-retinol dehydrogenase (NADP+) activity
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Accession:GO:0052650 term browser browse the term
Definition:Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
Synonyms:broad_synonym: all-trans retinal reductase activity;   all-trans-retinol dehydrogenase activity;   retinol dehydrogenase activity
 related_synonym: NADP(H)-dependent retinol dehydrogenase/reductase activity;   retinol dehydrogenase [NADP+] activity;   retinol:NADP+ oxidoreductase activity
 xref: EC:1.1.1.300;   KEGG_REACTION:R08379;   MetaCyc:RXN-10841;   RHEA:25033;   Reactome:R-HSA-2466861 "Defective RDH12 does not reduce atRAL to atROL";   reactome:R-HSA-2464803 "RDH8 reduces atRAL to atROL";   reactome:R-HSA-2464822 "RDH12 reduces atRAL to atROL";   reactome:R-HSA-2465921 "11cRDH oxidises 11cROL to 11cRAL";   reactome:R-HSA-2465940 "atRAL is reduced to atROL";   reactome:R-HSA-5419165 "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL";   reactome:R-HSA-5615668 "AKR1C3 reduces atRAL to atROL";   reactome:R-HSA-5623643 "RDH13 reduces atRAL to atROL";   reactome:R-HSA-74872 "RDH10,11 oxidise 11cROL to 11cRAL"


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all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 enables IDA
ISO		 (PMID:12732097) RGD PMID:12732097 PMID:20709016 RGD:6903952 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 enables ISO MGI:5007106 (PMID:24005908) RGD PMID:24005908 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Dhrs4 dehydrogenase/reductase 4 enables ISO
ISS		 (PMID:12604222)
GO_REF:0000024		 RGD
UniProt		 PMID:12604222 GO_REF:0000024 NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 enables ISO (PMID:26466768) RGD PMID:26466768 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892 		JBrowse link
G Rdh10 retinol dehydrogenase 10 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
G Rdh11 retinol dehydrogenase 11 enables ISO (PMID:12226107), (PMID:12807874) RGD PMID:12226107 PMID:12807874 NCBI chr 6:97,979,377...97,995,252
Ensembl chr 6:97,979,378...97,995,252 		JBrowse link
G Rdh12 retinol dehydrogenase 12 enables ISO (PMID:12226107) RGD PMID:12226107 NCBI chr 6:98,015,465...98,028,388
Ensembl chr 6:98,015,465...98,028,388 		JBrowse link
G Rdh13 retinol dehydrogenase 13 enables ISO
IBA		 (PMID:18039331)
GO_REF:0000033		 RGD
GO_Central		 PMID:18039331 GO_REF:0000033 NCBI chr 1:69,373,014...69,401,454
Ensembl chr 1:69,373,113...69,400,908 		JBrowse link
G Rdh14 retinol dehydrogenase 14 enables ISO (PMID:12435598)
(PMID:12226107)		 RGD PMID:12226107 PMID:12435598 NCBI chr 6:33,156,569...33,161,712
Ensembl chr 6:33,156,569...33,161,712 		JBrowse link
G Rdh8 retinol dehydrogenase 8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:19,353,191...19,360,462
Ensembl chr 8:19,353,191...19,360,462 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            alcohol dehydrogenase [NAD(P)+] activity 63
              aldo-keto reductase (NADPH) activity 45
                alcohol dehydrogenase (NADP+) activity 41
                  all-trans-retinol dehydrogenase (NADP+) activity 11
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