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ONTOLOGY REPORT - ANNOTATIONS

Term:all-trans-retinol dehydrogenase (NADP+) activity
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Accession:GO:0052650 term browser browse the term
Definition:Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.
Synonyms:broad_synonym: all-trans retinal reductase activity;   all-trans-retinol dehydrogenase activity;   retinol dehydrogenase activity
 related_synonym: NADP(H)-dependent retinol dehydrogenase/reductase activity;   retinol dehydrogenase [NADP+] activity;   retinol:NADP+ oxidoreductase activity
 xref: EC:1.1.1.300;   KEGG_REACTION:R08379;   MetaCyc:RXN-10841;   RHEA:25033;   Reactome:R-HSA-2466861 "Defective RDH12 does not reduce atRAL to atROL";   reactome:R-HSA-2464803 "RDH8 reduces atRAL to atROL";   reactome:R-HSA-2464822 "RDH12 reduces atRAL to atROL";   reactome:R-HSA-2465921 "11cRDH oxidises 11cROL to 11cRAL";   reactome:R-HSA-2465940 "atRAL is reduced to atROL";   reactome:R-HSA-5419165 "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL";   reactome:R-HSA-5615668 "AKR1C3 reduces atRAL to atROL";   reactome:R-HSA-5623643 "RDH13 reduces atRAL to atROL";   reactome:R-HSA-74872 "RDH10,11 oxidise 11cROL to 11cRAL"

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all-trans-retinol dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs3 dehydrogenase/reductase 3 enables ISO (PMID:24005908) MGI PMID:24005908 NCBI chrNW_004624818:557,399...590,872
Ensembl chrNW_004624818:557,409...590,872 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 enables ISO (PMID:26466768) UniProt PMID:26466768 NCBI chrNW_004624734:40,994,786...41,006,001
Ensembl chrNW_004624734:40,993,587...41,006,074 		JBrowse link
G Rdh10 retinol dehydrogenase 10 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624744:17,838,047...17,868,423
Ensembl chrNW_004624744:17,837,609...17,868,431 		JBrowse link
G Rdh11 retinol dehydrogenase 11 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:33,283,336...33,295,797
Ensembl chrNW_004624734:33,283,497...33,295,091 		JBrowse link
G Rdh12 retinol dehydrogenase 12 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:33,256,469...33,266,085
Ensembl chrNW_004624734:33,254,432...33,266,140 		JBrowse link
G Rdh13 retinol dehydrogenase 13 enables ISO (PMID:18039331) UniProt PMID:18039331 NCBI chrNW_004624832:2,141,906...2,159,009
Ensembl chrNW_004624832:2,141,902...2,159,009 		JBrowse link
G Rdh14 retinol dehydrogenase 14 enables ISO (PMID:12435598)
(PMID:12226107)		 UniProt PMID:12226107 PMID:12435598 NCBI chrNW_004624738:1,393,157...1,397,587 JBrowse link
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  molecular_function 18442
    catalytic activity 5600
      oxidoreductase activity 698
        oxidoreductase activity, acting on CH-OH group of donors 116
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 107
            alcohol dehydrogenase [NAD(P)+] activity 35
              aldo-keto reductase (NADPH) activity 23
                alcohol dehydrogenase (NADP+) activity 20
                  all-trans-retinol dehydrogenase (NADP+) activity 7
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