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ONTOLOGY REPORT - ANNOTATIONS

Term:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
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Accession:GO:0051903 term browser browse the term
Definition:Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
Synonyms:narrow_synonym: ADH3 activity;   chi-ADH activity
 related_synonym: FDH activity;   GD-FALDH activity;   GS-FDH activity;   NAD- and glutathione-dependent formaldehyde dehydrogenase activity;   NAD-dependent formaldehyde dehydrogenase activity;   NAD-linked formaldehyde dehydrogenase activity;   S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity;   class III alcohol dehydrogenase activity;   formic dehydrogenase activity;   glutathione-dependent formaldehyde dehydrogenase activity
 xref: EC:1.1.1.284;   KEGG_REACTION:R06983;   KEGG_REACTION:R07140;   MetaCyc:RXN-2962;   UM-BBD_reactionID:r1146;   reactome:R-HSA-5692237 "ADH5 oxidises S-HMGSH to S-FGSH"


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S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IBA
IEA		 GO_REF:0000033
GO_REF:0000003		 GO_Central
UniProt		 GO_REF:0000003 GO_REF:0000033 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide enables IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000003
MGI:3033711 (PMID:15919956)		 GO_Central
UniProt
RGD		 PMID:15919956 GO_REF:0000003 GO_REF:0000033 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity 2
              S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity 1
              S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity 1
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