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ONTOLOGY REPORT - ANNOTATIONS

Term:G-quadruplex DNA binding
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Accession:GO:0051880 term browser browse the term
Definition:Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.
Synonyms:exact_synonym: G quartet DNA binding;   G-DNA binding;   quadruplex DNA binding;   tetraplex DNA binding
 broad_synonym: G quartet binding


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G-quadruplex DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase enables ISO (PMID:11433031), (PMID:11735402) RGD PMID:11433031 PMID:11735402 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein enables ISO
IEA		 (PMID:23774591)
GO_REF:0000107		 RGD
Ensembl		 PMID:23774591 GO_REF:0000107 NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637 		JBrowse link
G Ddx11 DEAD/H-box helicase 11 enables ISO (PMID:26503245) RGD PMID:26503245 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550 		JBrowse link
G Dhx36 DEAH-box helicase 36 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:16150737), (PMID:18842585), (PMID:21586581), (PMID:21993297), (PMID:24151078)
GO_REF:0000033
(PMID:25611385)		 UniProt
RGD
GO_Central		 PMID:16150737 PMID:18842585 PMID:21586581 PMID:21993297 PMID:24151078 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial enables ISO (PMID:18174225) RGD PMID:18174225 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771 		JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 enables ISS
ISO		 GO_REF:0000024
(PMID:25679041)		 UniProt
RGD		 PMID:25679041 GO_REF:0000024 NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538 		JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 8:66,110,641...66,120,202
Ensembl chr 8:66,111,072...66,120,200 		JBrowse link
G Rad50 RAD50 double strand break repair protein enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Wrn WRN RecQ like helicase enables ISO (PMID:11433031), (PMID:11735402) RGD PMID:11433031 PMID:11735402 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
G Xrn1 5'-3' exoribonuclease 1 enables ISO (PMID:9049243) RGD PMID:9049243 NCBI chr 8:96,527,871...96,637,385
Ensembl chr 8:96,528,195...96,632,739 		JBrowse link
telomeric G-quadruplex DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase enables ISO (PMID:19734539) RGD PMID:19734539 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Pot1 protection of telomeres 1 NOT|enables ISO (PMID:19734539) RGD PMID:19734539 NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042 		JBrowse link
G Wrn WRN RecQ like helicase enables ISO (PMID:19734539) RGD PMID:19734539 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20626
    binding 17717
      organic cyclic compound binding 6134
        nucleic acid binding 3844
          DNA binding 2276
            G-quadruplex DNA binding 11
              telomeric G-quadruplex DNA binding 3
paths to the root