Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular pH reduction
go back to main search page
Accession:GO:0051452 term browser browse the term
Definition:Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
Synonyms:exact_synonym: cell pH reduction;   cellular acidification;   reduction of cellular pH;   reduction of pH in cell
 related_synonym: intracellular acidification


show annotations for term's descendants           Sort by:
intracellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr89b G protein-coupled receptor 89B involved_in ISO
IBA		 (PMID:18794847)
GO_REF:0000033		 RGD
GO_Central		 PMID:18794847 GO_REF:0000033 NCBI chr 2:184,408,136...184,445,560 JBrowse link
G Slc12a5 solute carrier family 12 member 5 IDA RGD PMID:16420452 RGD:2303953 NCBI chr 3:174,115,833...174,155,112 JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO (PMID:23908015) RGD PMID:23908015 NCBI chr 1:201,127,034...201,138,787 JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO (PMID:27140606)
(PMID:27231233)		 RGD PMID:27140606 PMID:27231233 NCBI chr 1:200,416,538...200,446,252 JBrowse link
G Ttpa alpha tocopherol transfer protein IDA RGD PMID:22147702 RGD:7247589 NCBI chr 5:38,294,415...38,315,471 JBrowse link
endosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 acts_upstream_of_or_within ISO MGI:3528447 (PMID:16107722) RGD PMID:16107722 NCBI chr 1:152,046,515...152,056,675 JBrowse link
G Faslg Fas ligand IDA RGD PMID:18045865 RGD:2315735 NCBI chr13:76,680,885...76,706,042 JBrowse link
G Rnasek ribonuclease K involved_in ISO UniProtKB:Q15904 (PMID:26212330) RGD PMID:26212330 NCBI chr10:54,954,904...54,956,622 JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832 JBrowse link
lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO
IEA
ISS		 (PMID:32276428)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:32276428 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:10,183,983...10,210,948 JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr 9:36,650,384...36,654,348 JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO
IBA		 (PMID:11722572)
GO_REF:0000033		 RGD
GO_Central		 PMID:11722572 GO_REF:0000033 NCBI chr 1:190,586,649...190,600,034 JBrowse link
G Cln5 CLN5, intracellular trafficking protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr15:79,893,573...79,903,438 JBrowse link
G Cln6 CLN6, transmembrane ER protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr 8:63,303,356...63,318,360 JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) RGD PMID:33966596 NCBI chr13:80,552,779...80,565,272 JBrowse link
G Grn granulin precursor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28073925)		 UniProt
Ensembl
RGD		 PMID:28073925 GO_REF:0000024 GO_REF:0000107 NCBI chr10:87,387,672...87,393,777 JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:37390818)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:37390818 GO_REF:0000024 GO_REF:0000107 NCBI chr16:83,058,131...83,082,843 JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:37390818)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:37390818 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:122,038,734...122,087,745 JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO
ISS		 (PMID:11722572)
PMID:8895569		 RGD PMID:11722572 PMID:8895569 RGD:8553248 NCBI chr 5:135,121,164...135,142,048 JBrowse link
G Snapin SNAP-associated protein acts_upstream_of_or_within ISO MGI:3608768 (PMID:20920792) RGD PMID:20920792 NCBI chr 2:178,269,157...178,271,746 JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO MGI:5319917 (PMID:28728022) RGD PMID:28728022 NCBI chr 4:41,328,125...41,347,315 JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO
IEA
ISS		 (PMID:28296633)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28296633 GO_REF:0000024 GO_REF:0000107 NCBI chr10:63,402,493...63,407,065 JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832 JBrowse link
negative regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator involved_in ISO
IEA		 (PMID:10506221)
GO_REF:0000107		 RGD
Ensembl		 PMID:10506221 GO_REF:0000107 NCBI chr13:23,204,464...23,366,900 JBrowse link
phagosome acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab20 RAB20, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr16:84,721,427...84,745,610 JBrowse link
G Rab38 RAB38, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr 1:142,182,566...142,262,923 JBrowse link
G Rab39a RAB39A, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr 8:54,088,246...54,105,867 JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO
ISS		 (PMID:21255211)
GO_REF:0000024		 RGD
UniProt		 PMID:21255211 GO_REF:0000024 NCBI chr 4:120,461,966...120,510,756 JBrowse link
G Slamf8 SLAM family member 8 acts_upstream_of_or_within ISO MGI:5442794 (PMID:22593622) RGD PMID:22593622 NCBI chr13:85,047,729...85,057,571 JBrowse link
G Slc4a7 solute carrier family 4 member 7 involved_in ISO (PMID:29779931) RGD PMID:29779931 NCBI chr15:10,585,307...10,664,780 JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO MGI:3852642 (PMID:19549681) RGD PMID:19549681 NCBI chr 1:201,127,034...201,138,787 JBrowse link
positive regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin IMP RGD PMID:17762181 RGD:2300343 NCBI chr 3:117,793,447...117,805,091 JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:17762181 RGD:2300343 NCBI chr 7:58,114,306...58,118,230 JBrowse link
G Avpr1b arginine vasopressin receptor 1B IMP RGD PMID:17762181 RGD:2300343 NCBI chr13:43,046,531...43,059,046 JBrowse link
G Car2 carbonic anhydrase 2 acts_upstream_of_or_within IMP
ISO		 MGI:2135646 (PMID:23881097) RGD PMID:23881097 PMID:9665810 RGD:1342423 NCBI chr 2:88,462,883...88,478,012 JBrowse link
G Car7 carbonic anhydrase 7 acts_upstream_of_or_within ISO MGI:5543604 (PMID:23881097) RGD PMID:23881097 NCBI chr19:435,520...444,927 JBrowse link
positive regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube3a ubiquitin protein ligase E3A involved_in IMP
ISO		 PMID:23447592
(PMID:23447592)		 RGD PMID:23447592 PMID:23447592 RGD:15023469 NCBI chr 1:110,070,260...110,161,675 JBrowse link
regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc9a7 solute carrier family 9 member A7 involved_in ISO (PMID:30335141) RGD PMID:30335141 NCBI chr  X:2,214,064...2,395,052 JBrowse link
G Slc9a8 solute carrier family 9 member A8 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15522866)		 Ensembl
RGD		 PMID:15522866 GO_REF:0000107 NCBI chr 3:156,147,855...156,198,497 JBrowse link
vacuolar acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:85,935,802...85,989,901 JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:66,760,163...66,842,126 JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:50,313,268...50,357,248 JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:38,133,151...38,182,245 JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:116,223,799...116,242,475 JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 involved_in TAS
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:15013950 GO_REF:0000033, RGD:1304309 NCBI chr16:20,617,515...20,641,651 JBrowse link
G Clic4 chloride intracellular channel 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3838012 (PMID:19197003)		 Ensembl
RGD		 PMID:19197003 GO_REF:0000107 NCBI chr 5:147,453,702...147,513,455 JBrowse link
G Dmxl1 Dmx-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:45,179,505...45,349,999 JBrowse link
G Dmxl2 Dmx-like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:63,637,314...63,803,911 JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2446573 (PMID:11067873), (PMID:18984740), (PMID:9670047)		 Ensembl
RGD		 PMID:9670047 PMID:11067873 PMID:18984740 GO_REF:0000107 NCBI chr 9:75,957,193...75,968,115 JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:201,127,034...201,138,787 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological quality 3448
        regulation of intracellular pH 83
          intracellular pH reduction 47
            Golgi lumen acidification + 3
            endosomal lumen acidification 4
            negative regulation of cellular pH reduction + 1
            phagosome acidification + 7
            positive regulation of cellular pH reduction + 6
            regulation of cellular pH reduction + 9
            vacuolar acidification + 25
Path 2
Term Annotations click to browse term
  biological_process 20534
    homeostatic process 2014
      chemical homeostasis 1225
        monoatomic ion homeostasis 680
          monoatomic cation homeostasis 666
            regulation of pH 107
              regulation of cellular pH 92
                regulation of intracellular pH 83
                  intracellular pH reduction 47
                    Golgi lumen acidification + 3
                    endosomal lumen acidification 4
                    negative regulation of cellular pH reduction + 1
                    phagosome acidification + 7
                    positive regulation of cellular pH reduction + 6
                    regulation of cellular pH reduction + 9
                    vacuolar acidification + 25
paths to the root