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ONTOLOGY REPORT - ANNOTATIONS

Term:NK T cell activation
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Accession:GO:0051132 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
Comment:Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
Synonyms:exact_synonym: NK T lymphocyte activation;   NKT cell activation;   NT cell activation;   natural T cell activation;   natural killer T cell activation


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NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 acts_upstream_of_or_within ISO (PMID:30323255) RGD PMID:30323255 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in IEA
ISO 		GO_REF:0000107
(PMID:18852879) 		Ensembl
RGD		 PMID:18852879 GO_REF:0000107 NCBI chr20:3,680,607...3,693,329
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Clec4f C-type lectin domain family 4, member F acts_upstream_of_or_within ISO MGI:5529277 (PMID:23762286) RGD PMID:23762286 NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775 		JBrowse link
G Klrb1 killer cell lectin like receptor B1 involved_in ISO (PMID:17057721) RGD PMID:17057721 NCBI chr 4:162,456,294...162,474,989
Ensembl chr 4:162,456,294...162,474,989 		JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:15294952), (PMID:18852879), (PMID:19528259) 		Ensembl
RGD		 PMID:15294952 PMID:18852879 PMID:19528259 GO_REF:0000107 NCBI chr20:3,637,242...3,643,748
Ensembl chr20:3,638,240...3,643,799 		JBrowse link
G Ncr3lg1 natural killer cell cytotoxicity receptor 3 ligand 1 involved_in ISO (PMID:19528259) RGD PMID:19528259 NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466 		JBrowse link
negative regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in ISO (PMID:10540326) RGD PMID:10540326 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Lgals3 galectin 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:26582946) 		Ensembl
RGD		 PMID:26582946 GO_REF:0000107 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO
IEA 		(PMID:23105140)
GO_REF:0000107 		RGD
Ensembl		 PMID:23105140 GO_REF:0000107 NCBI chr 2:177,093,569...177,111,894
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elf4 E74 like ETS transcription factor 4 involved_in ISO
IEA 		(PMID:12387738)
GO_REF:0000107 		RGD
Ensembl		 PMID:12387738 GO_REF:0000107 NCBI chr  X:127,587,401...127,639,063
Ensembl chr  X:127,590,650...127,630,200 		JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within ISO
IEA 		MGI:2136897 (PMID:10704459)
GO_REF:0000107 		RGD
Ensembl		 PMID:10704459 GO_REF:0000107 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO MGI:2178233 (PMID:19423665) RGD PMID:19423665 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
positive regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO (PMID:10201995), (PMID:11754812), (PMID:7538697) RGD PMID:7538697 PMID:10201995 PMID:11754812 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Il12a interleukin 12A involved_in ISO
IEA 		(PMID:19088061)
GO_REF:0000107 		RGD
Ensembl		 PMID:19088061 GO_REF:0000107 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B involved_in ISO
IEA 		(PMID:19088061)
GO_REF:0000107 		RGD
Ensembl		 PMID:19088061 GO_REF:0000107 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IEA 		(PMID:19088061)
GO_REF:0000107 		RGD
Ensembl		 PMID:19088061 GO_REF:0000107 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923 		JBrowse link
positive regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12b interleukin 12B involved_in ISO
IEA 		(PMID:19088061)
GO_REF:0000107 		RGD
Ensembl		 PMID:19088061 GO_REF:0000107 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19088061) 		Ensembl
RGD		 PMID:19088061 GO_REF:0000107 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IEA 		(PMID:19088061)
GO_REF:0000107 		RGD
Ensembl		 PMID:19088061 GO_REF:0000107 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO
IEA 		(PMID:19088061)
GO_REF:0000107 		RGD
Ensembl		 PMID:19088061 GO_REF:0000107 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Rasal3 RAS protein activator like 3 involved_in ISO
IEA 		(PMID:25652366)
GO_REF:0000107 		RGD
Ensembl		 PMID:25652366 GO_REF:0000107 NCBI chr 7:11,396,554...11,411,347
Ensembl chr 7:11,396,090...11,411,465 		JBrowse link
G Tyk2 tyrosine kinase 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    immune system process 3132
      leukocyte activation 1084
        lymphocyte activation 878
          T cell activation 623
            alpha-beta T cell activation 215
              NK T cell activation 20
                NK T cell activation involved in immune response + 0
                NK T cell proliferation + 10
                negative regulation of NK T cell activation + 3
                positive regulation of NK T cell activation + 8
                regulation of NK T cell activation + 11
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cell activation 1242
        leukocyte activation 1084
          lymphocyte activation 878
            T cell activation 623
              alpha-beta T cell activation 215
                NK T cell activation 20
                  NK T cell activation involved in immune response + 0
                  NK T cell proliferation + 10
                  negative regulation of NK T cell activation + 3
                  positive regulation of NK T cell activation + 8
                  regulation of NK T cell activation + 11
paths to the root