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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of B cell activation
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Accession:GO:0050869 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
Synonyms:exact_synonym: down regulation of B cell activation;   downregulation of B cell activation;   negative regulation of B lymphocyte activation
 narrow_synonym: inhibition of B cell activation



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negative regulation of B cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bank1 B-cell scaffold protein with ankyrin repeats 1 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:88336 (PMID:16546095)
GO_Central
RGD
PMID:16546095 GO_REF:0000033 NCBI chr 2:227,203,998...227,474,008
Ensembl chr 2:224,530,475...224,800,405
JBrowse link
G Btk Bruton tyrosine kinase IMP RGD PMID:25545336 RGD:151665128 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856334 (PMID:6610701) RGD PMID:6610701 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Foxj1 forkhead box J1 involved_in IEA
ISO
GO_REF:0000107
(PMID:16002694)
Ensembl
RGD
PMID:16002694 GO_REF:0000107 NCBI chr10:102,065,163...102,069,945
Ensembl chr10:101,566,304...101,570,237
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO MGI:2386884 (PMID:10704460) RGD PMID:10704460 NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (PMID:20519653) RGD PMID:20519653 NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO (PMID:24803541) RGD PMID:24803541 NCBI chr11:96,169,028...96,169,107
Ensembl chr11:82,664,716...82,664,795
JBrowse link
G Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 involved_in ISO
IBA
(PMID:19923443)
GO_REF:0000033
RGD
GO_Central
PMID:19923443 GO_REF:0000033 NCBI chr11:14,484,523...14,534,900
Ensembl chr11:14,483,893...14,534,900
JBrowse link
G Tbc1d10c TBC1 domain family, member 10C acts_upstream_of_or_within ISO MGI:1932389|MGI:5578034 (PMID:23109291) RGD PMID:23109291 NCBI chr 1:210,906,621...210,913,649
Ensembl chr 1:201,477,157...201,564,920
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:21088135) RGD PMID:21088135 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt3 Fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (PMID:16618805) RGD PMID:16618805 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Hmgb3 high mobility group box 3 acts_upstream_of_or_within ISO (PMID:12714519) RGD PMID:12714519 NCBI chr  X:154,341,106...154,346,087
Ensembl chr  X:149,296,375...149,301,292
JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:2384134 (PMID:18523151) RGD PMID:18523151 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA
(PMID:18941195)
GO_REF:0000107
RGD
Ensembl
PMID:18941195 GO_REF:0000107 NCBI chr16:75,278,325...75,316,736
Ensembl chr16:68,575,763...68,614,286
JBrowse link
negative regulation of B cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Btk Bruton tyrosine kinase acts_upstream_of_or_within ISO MGI:1856317 (PMID:7680896) RGD PMID:7680896 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G Btla B and T lymphocyte associated acts_upstream_of_or_within ISO MGI:3027713 (PMID:12796776) RGD PMID:12796776 NCBI chr11:69,069,734...69,099,331
Ensembl chr11:55,564,899...55,587,181
JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO MGI:2178778 (PMID:12970760) RGD PMID:12970760 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO (PMID:8920854) RGD PMID:8920854 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662
JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:100,428,826...100,441,693
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:15964995) RGD PMID:15964995 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Fcgr2b Fc gamma receptor 2B acts_upstream_of_or_within ISO MGI:1857166 (PMID:12385742), (PMID:8552190) RGD PMID:8552190 PMID:12385742 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Il10 interleukin 10 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:9184696)
UniProt
RGD
PMID:9184696 GO_REF:0000024 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (PMID:10704460)
Ensembl
RGD
PMID:10704460 GO_REF:0000107 NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:9252121) RGD PMID:9252121 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO (PMID:24803541) RGD PMID:24803541 NCBI chr11:96,169,028...96,169,107
Ensembl chr11:82,664,716...82,664,795
JBrowse link
G Mnda myeloid cell nuclear differentiation antigen involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr13:88,550,224...88,567,892
Ensembl chr13:86,017,892...86,034,201
JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO MGI:2678021 (PMID:12970181) RGD PMID:12970181 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pkn1 protein kinase N1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5475202 (PMID:23223530)
Ensembl
RGD
PMID:23223530 GO_REF:0000107 NCBI chr19:41,346,855...41,374,832
Ensembl chr19:24,442,122...24,470,107
JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO MGI:1857936 (PMID:16027169) RGD PMID:16027169 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (PMID:18172933) RGD PMID:18172933 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link
G Tnfrsf13b TNF receptor superfamily member 13B involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:3052983 (PMID:15240667)
GO_Central
RGD
PMID:15240667 GO_REF:0000033 NCBI chr10:46,301,336...46,322,460
Ensembl chr10:45,801,860...45,822,987
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:12515813)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:12515813 GO_REF:0000024 GO_REF:0000033 NCBI chr 9:25,376,400...25,451,323
Ensembl chr 9:17,879,156...17,954,085
JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO MGI:109583 (PMID:16027169) RGD PMID:16027169 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO
IBA
(PMID:21727189)
GO_REF:0000033
RGD
GO_Central
PMID:21727189 GO_REF:0000033 NCBI chr 1:94,800,372...94,804,307
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (PMID:26000965) RGD PMID:26000965 NCBI chr 8:115,989,721...115,995,822
Ensembl chr 8:107,111,012...107,116,782
JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein involved_in ISO MGI:6723808|MGI:7719862 (PMID:24399151) RGD PMID:24399151 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (PMID:10490661) RGD PMID:10490661 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (PMID:16275384) RGD PMID:16275384 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3695433 (PMID:17137798)
Ensembl
RGD
PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311
JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158439 (PMID:15240705) RGD PMID:15240705 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    immune system process 3120
      leukocyte activation 1075
        lymphocyte activation 869
          B cell activation 306
            negative regulation of B cell activation 38
              negative regulation of B cell differentiation + 5
              negative regulation of B cell proliferation 22
              negative regulation of isotype switching + 5
Path 2
Term Annotations click to browse term
  biological_process 20553
    biological regulation 13833
      regulation of biological process 13387
        regulation of multicellular organismal process 3345
          negative regulation of multicellular organismal process 1357
            negative regulation of cell activation 242
              negative regulation of leukocyte activation 222
                negative regulation of lymphocyte activation 191
                  negative regulation of B cell activation 38
                    negative regulation of B cell differentiation + 5
                    negative regulation of B cell proliferation 22
                    negative regulation of isotype switching + 5
paths to the root