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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of B cell activation
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Accession:GO:0050864 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of B cell activation.
Synonyms:exact_synonym: regulation of B lymphocyte activation



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regulation of B cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd19 CD19 molecule involved_in ISO (PMID:1373518) RGD PMID:1373518 NCBI chr 1:190,417,853...190,424,494 JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma acts_upstream_of_or_within ISO MGI:3759678 (PMID:16129705) RGD PMID:16129705 NCBI chr 6:72,647,025...72,670,885 JBrowse link
G Themis2 thymocyte selection associated family member 2 involved_in ISO (PMID:24907343) RGD PMID:24907343 NCBI chr 5:150,275,094...150,290,343 JBrowse link
G Tlr9 toll-like receptor 9 acts_upstream_of_or_within ISO MGI:1922072 (PMID:23109291) RGD PMID:23109291 NCBI chr 8:115,743,407...115,747,523 JBrowse link
B cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd320 CD320 molecule involved_in ISO
ISS
(PMID:10727470)
GO_REF:0000024
RGD
UniProt
PMID:10727470 GO_REF:0000024 NCBI chr 7:14,626,171...14,631,976 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18762567) RGD PMID:18762567 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:15240667)
GO_Central
RGD
PMID:15240667 GO_REF:0000033 NCBI chr 7:113,736,046...113,738,523 JBrowse link
G Tnfsf13b TNF superfamily member 13b acts_upstream_of_or_within ISO (PMID:15240667) RGD PMID:15240667 NCBI chr16:79,462,406...79,492,888 JBrowse link
negative regulation of B cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bank1 B-cell scaffold protein with ankyrin repeats 1 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:88336 (PMID:16546095)
GO_Central
RGD
PMID:16546095 GO_REF:0000033 NCBI chr 2:224,530,475...224,800,420 JBrowse link
G Btk Bruton tyrosine kinase IMP RGD PMID:25545336 RGD:151665128 NCBI chr  X:102,016,070...102,055,448 JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856334 (PMID:6610701) RGD PMID:6610701 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Foxj1 forkhead box J1 involved_in IEA
ISO
GO_REF:0000107
(PMID:16002694)
Ensembl
RGD
PMID:16002694 GO_REF:0000107 NCBI chr10:101,566,299...101,570,370 JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO MGI:2386884 (PMID:10704460) RGD PMID:10704460 NCBI chr 9:95,735,533...95,840,584 JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (PMID:20519653) RGD PMID:20519653 NCBI chr 5:143,087,759...143,109,807 JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO (PMID:24803541) RGD PMID:24803541 NCBI chr11:82,664,716...82,664,795 JBrowse link
G Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 involved_in ISO
IBA
(PMID:19923443)
GO_REF:0000033
RGD
GO_Central
PMID:19923443 GO_REF:0000033 NCBI chr11:27,971,565...28,021,944 JBrowse link
G Tbc1d10c TBC1 domain family, member 10C acts_upstream_of_or_within ISO MGI:1932389|MGI:5578034 (PMID:23109291) RGD PMID:23109291 NCBI chr 1:201,476,258...201,484,876 JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:21088135) RGD PMID:21088135 NCBI chr 1:15,528,921...15,543,993 JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt3 Fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (PMID:16618805) RGD PMID:16618805 NCBI chr12:12,660,035...12,735,584 JBrowse link
G Hmgb3 high mobility group box 3 acts_upstream_of_or_within ISO (PMID:12714519) RGD PMID:12714519 NCBI chr  X:149,296,303...149,301,290 JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:2384134 (PMID:18523151) RGD PMID:18523151 NCBI chr 6:47,469,162...47,470,995 JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA
(PMID:18941195)
GO_REF:0000107
RGD
Ensembl
PMID:18941195 GO_REF:0000107 NCBI chr16:75,278,325...75,316,736 JBrowse link
negative regulation of B cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 8:62,724,939...62,829,040 JBrowse link
G Btk Bruton tyrosine kinase acts_upstream_of_or_within ISO MGI:1856317 (PMID:7680896) RGD PMID:7680896 NCBI chr  X:102,016,070...102,055,448 JBrowse link
G Btla B and T lymphocyte associated acts_upstream_of_or_within ISO MGI:3027713 (PMID:12796776) RGD PMID:12796776 NCBI chr11:69,069,734...69,099,331 JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO MGI:2178778 (PMID:12970760) RGD PMID:12970760 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO (PMID:8920854) RGD PMID:8920854 NCBI chr20:47,074,353...47,079,662 JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:99,929,801...99,942,674 JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:15964995) RGD PMID:15964995 NCBI chr 5:109,100,763...109,114,448 JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 9:69,812,859...69,819,959 JBrowse link
G Fcgr2b Fc gamma receptor 2B acts_upstream_of_or_within ISO MGI:1857166 (PMID:12385742), (PMID:8552190) RGD PMID:8552190 PMID:12385742 NCBI chr13:85,725,897...85,740,517 JBrowse link
G Il10 interleukin 10 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:9184696)
UniProt
RGD
PMID:9184696 GO_REF:0000024 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (PMID:10704460)
Ensembl
RGD
PMID:10704460 GO_REF:0000107 NCBI chr 9:95,735,533...95,840,584 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:9252121) RGD PMID:9252121 NCBI chr 5:21,437,127...21,553,097 JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO (PMID:24803541) RGD PMID:24803541 NCBI chr11:82,664,716...82,664,795 JBrowse link
G Mnda myeloid cell nuclear differentiation antigen involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr13:86,017,888...86,035,556 JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO MGI:2678021 (PMID:12970181) RGD PMID:12970181 NCBI chr 7:45,531,480...45,611,492 JBrowse link
G Pkn1 protein kinase N1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5475202 (PMID:23223530)
Ensembl
RGD
PMID:23223530 GO_REF:0000107 NCBI chr19:41,346,855...41,374,832 JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO MGI:1857936 (PMID:16027169) RGD PMID:16027169 NCBI chr 1:240,043,707...240,110,330 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (PMID:18172933) RGD PMID:18172933 NCBI chr13:73,174,075...73,245,762 JBrowse link
G Tnfrsf13b TNF receptor superfamily member 13B involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:3052983 (PMID:15240667)
GO_Central
RGD
PMID:15240667 GO_REF:0000033 NCBI chr10:46,301,336...46,322,460 JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:12515813)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:12515813 GO_REF:0000024 GO_REF:0000033 NCBI chr 9:17,879,156...17,954,085 JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO MGI:109583 (PMID:16027169) RGD PMID:16027169 NCBI chr10:14,125,679...14,160,317 JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO
IBA
(PMID:21727189)
GO_REF:0000033
RGD
GO_Central
PMID:21727189 GO_REF:0000033 NCBI chr 1:85,672,931...85,676,856 JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (PMID:26000965) RGD PMID:26000965 NCBI chr 8:107,111,010...107,117,073 JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (PMID:10490661) RGD PMID:10490661 NCBI chr11:76,854,090...76,877,389 JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (PMID:16275384) RGD PMID:16275384 NCBI chr  X:17,580,380...17,601,181 JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3695433 (PMID:17137798)
Ensembl
RGD
PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068 JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158439 (PMID:15240705) RGD PMID:15240705 NCBI chr11:76,854,090...76,877,389 JBrowse link
positive regulation of B cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akirin2 akirin 2 involved_in ISO (PMID:26041538) RGD PMID:26041538 NCBI chr 5:49,108,231...49,122,566 JBrowse link
G Cd81 Cd81 molecule involved_in ISS
ISO
GO_REF:0000024
(PMID:23499492)
UniProt
RGD
PMID:23499492 GO_REF:0000024 NCBI chr 1:207,665,274...207,681,094 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:16129705), (PMID:8566034), (PMID:9798653) RGD PMID:8566034 PMID:9798653 PMID:16129705 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:3491322) RGD PMID:3491322 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in ISO (PMID:20844241) RGD PMID:20844241 NCBI chr19:34,555,832...34,596,281 JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:4361448 (PMID:19734906) RGD PMID:19734906 NCBI chr14:99,455,970...99,510,474 JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:29636373)
Ensembl
RGD
PMID:29636373 GO_REF:0000107 NCBI chr  X:38,686,530...39,031,658 JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 acts_upstream_of_or_within ISO MGI:3029019 (PMID:12855817) RGD PMID:12855817 NCBI chr 9:1,102,559...1,111,023 JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (PMID:23857366) RGD PMID:23857366 NCBI chr 8:115,743,407...115,747,523 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:9670042) RGD PMID:9670042 NCBI chr13:76,256,654...76,280,133 JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in ISO (PMID:16633345) RGD PMID:16633345 NCBI chr14:80,452,936...80,470,141 JBrowse link
positive regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp11c ATPase phospholipid transporting 11C involved_in ISO (PMID:21423173) RGD PMID:21423173 NCBI chr  X:138,564,459...138,752,116 JBrowse link
G Bad BCL2-associated agonist of cell death involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3029528 (PMID:12431371)
Ensembl
RGD
PMID:12431371 GO_REF:0000107 NCBI chr 1:213,562,719...213,572,034 JBrowse link
G Cd27 CD27 molecule involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:158,030,700...158,035,862 JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:2429736|MGI:5544783 (PMID:23918385), (PMID:9252128) RGD PMID:9252128 PMID:23918385 NCBI chr  X:66,395,330...66,399,026 JBrowse link
G Il7 interleukin 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:16797412)
Ensembl
RGD
PMID:16797412 GO_REF:0000107 NCBI chr 2:96,142,523...96,186,282 JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:2386884 (PMID:10704460), (PMID:9620849)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:9620849 PMID:10704460 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:95,735,533...95,840,584 JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in ISS
ISO
GO_REF:0000024
(PMID:21572390)
UniProt
RGD
PMID:21572390 GO_REF:0000024 NCBI chr15:27,887,795...27,897,020 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO
GO_REF:0000024
(PMID:19015308)
UniProt
RGD
PMID:19015308 GO_REF:0000024 NCBI chr 7:136,455,900...136,501,384 JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947) RGD PMID:20870947 NCBI chr16:83,125,386...83,150,851 JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:3759678 (PMID:16129705)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:16129705 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:72,647,025...72,670,885 JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO
IEA
ISS
(PMID:33951726)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:33951726 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:77,059,744...77,093,730 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (PMID:10979977) RGD PMID:10979977 NCBI chr10:86,285,859...86,310,187 JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:103036 (PMID:10979977)
Ensembl
RGD
PMID:10979977 GO_REF:0000107 NCBI chr10:85,704,841...85,775,856 JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857421|MGI:2384078 (PMID:7477352), (PMID:7477353)
(PMID:18369315)
Ensembl
RGD
PMID:7477352 PMID:7477353 PMID:18369315 GO_REF:0000107 NCBI chr17:12,756,493...12,830,927 JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
ISS
(PMID:11460154)
GO_REF:0000024
RGD
UniProt
PMID:11460154 GO_REF:0000024 NCBI chr14:84,604,623...84,609,707 JBrowse link
positive regulation of B cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857117|MGI:2683027 (PMID:14607964)
Ensembl
RGD
PMID:14607964 GO_REF:0000107 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:4127920 (PMID:25404367) RGD PMID:25404367 NCBI chr10:65,568,569...65,616,379 JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in ISO
IEA
(PMID:17875758)
GO_REF:0000107
RGD
Ensembl
PMID:17875758 GO_REF:0000107 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158437 (PMID:9171827) RGD PMID:9171827 NCBI chr11:76,854,090...76,877,389 JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger involved_in ISO (PMID:15964995) RGD PMID:15964995 NCBI chr17:81,332,175...81,341,625 JBrowse link
G Bst1 bone marrow stromal cell antigen 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:71,466,179...71,482,671 JBrowse link
G Btk Bruton tyrosine kinase IMP RGD PMID:28352114 RGD:151665126 NCBI chr  X:102,016,070...102,055,448 JBrowse link
G Card11 caspase recruitment domain family, member 11 acts_upstream_of_or_within ISO MGI:3039682 (PMID:12867038) RGD PMID:12867038 NCBI chr12:18,735,088...18,872,045 JBrowse link
G Cd320 CD320 molecule involved_in ISO
ISS
(PMID:10727470)
GO_REF:0000024
RGD
UniProt
PMID:10727470 GO_REF:0000024 NCBI chr 7:14,626,171...14,631,976 JBrowse link
G Cd38 CD38 molecule involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:17875758)
(PMID:8666928)
GO_REF:0000033
RGD
GO_Central
PMID:8666928 PMID:17875758 GO_REF:0000033 NCBI chr14:71,384,532...71,424,794 JBrowse link
G Cd40 CD40 molecule acts_upstream_of_or_within ISO MGI:87891 (PMID:10979977), (PMID:11894097), (PMID:14607964), (PMID:15963492), (PMID:8666928), (PMID:8920854) RGD PMID:8666928 PMID:8920854 PMID:10979977 PMID:11894097 PMID:14607964 More... NCBI chr 3:174,209,113...174,224,592 JBrowse link
G Cd40lg CD40 ligand IDA RGD PMID:18384807 RGD:2313415 NCBI chr  X:140,164,341...140,176,057 JBrowse link
G Cd74 CD74 molecule involved_in ISO
IEA
(PMID:12782713)
GO_REF:0000107
RGD
Ensembl
PMID:12782713 GO_REF:0000107 NCBI chr18:54,256,757...54,266,003 JBrowse link
G Cd81 Cd81 molecule involved_in ISO
IEA
(PMID:10400713)
GO_REF:0000107
RGD
Ensembl
PMID:10400713 GO_REF:0000107 NCBI chr 1:207,665,274...207,681,094 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A acts_upstream_of_or_within ISO MGI:107739 (PMID:12970760) RGD PMID:12970760 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:88336 (PMID:15963492) RGD PMID:15963492 NCBI chr 2:175,181,402...175,189,619 JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 involved_in IBA
ISO
GO_REF:0000033
(PMID:12023368)
GO_Central
RGD
PMID:12023368 GO_REF:0000033 NCBI chr 1:201,507,763...201,517,607 JBrowse link
G Ephb2 Eph receptor B2 involved_in ISO (PMID:24803541) RGD PMID:24803541 NCBI chr 5:154,179,065...154,360,459 JBrowse link
G Gpr183 G protein-coupled receptor 183 involved_in ISS
ISO
GO_REF:0000024
(PMID:21673108)
UniProt
RGD
PMID:21673108 GO_REF:0000024 NCBI chr15:105,445,129...105,457,192 JBrowse link
G Il13 interleukin 13 IDA requires CD40 antigen RGD PMID:11573960 PMID:10331006 RGD:633067, RGD:61509 NCBI chr10:38,290,926...38,293,483 JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 IDA requires CD40 antigen RGD PMID:11573960 RGD:633067 NCBI chr  X:120,213,670...120,294,777 JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO (PMID:9184696) RGD PMID:9184696 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17673207)
GO_REF:0000107
RGD
Ensembl
PMID:17673207 GO_REF:0000107 NCBI chr 2:120,117,105...120,127,012 JBrowse link
G Il3 interleukin 3 acts_upstream_of_or_within ISO (PMID:7736574) RGD PMID:7736574 NCBI chr10:38,906,460...38,908,810 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:10979977), (PMID:14607964) RGD PMID:10979977 PMID:14607964 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il5 interleukin 5 IDA RGD PMID:10529595 RGD:2303750 NCBI chr10:38,375,132...38,378,003 JBrowse link
G Il7 interleukin 7 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
MGI:87859 (PMID:12970760), (PMID:7671324)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:7671324 PMID:12970760 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:96,142,523...96,186,282 JBrowse link
G Irs2 insulin receptor substrate 2 involved_in ISO (PMID:15572028) RGD PMID:15572028 NCBI chr16:85,190,310...85,214,543 JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO
GO_REF:0000024
(PMID:18955699)
UniProt
RGD
PMID:18955699 GO_REF:0000024 NCBI chr 2:15,708,732...15,871,639 JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:12782713) RGD PMID:12782713 NCBI chr20:12,790,919...12,791,784 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO
ISS
(PMID:17875758)
GO_REF:0000024
RGD
UniProt
PMID:17875758 GO_REF:0000024 NCBI chr 7:136,455,900...136,501,384 JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 3:177,615,189...177,747,493 JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:4361448 (PMID:19734906) RGD PMID:19734906 NCBI chr14:99,455,970...99,510,474 JBrowse link
G Prlr prolactin receptor IMP RGD PMID:8650199 PMID:9447986 RGD:151665811, RGD:151667430 NCBI chr 2:60,861,391...61,051,883 JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in
acts_upstream_of_or_within
ISO (PMID:1793833)
MGI:1857277|MGI:2181288 (PMID:8566034), (PMID:8666928), (PMID:9015183), (PMID:9254656)
RGD PMID:1793833 PMID:8566034 PMID:8666928 PMID:9015183 PMID:9254656 NCBI chr13:52,147,717...52,259,810 JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:3716944 (PMID:16227612)
GO_REF:0000033
RGD
GO_Central
PMID:16227612 GO_REF:0000033 NCBI chr  X:132,204,717...132,219,421 JBrowse link
G Slc39a10 solute carrier family 39 member 10 acts_upstream_of_or_within ISO MGI:5642299 (PMID:25074919) RGD PMID:25074919 NCBI chr 9:62,331,281...62,454,754 JBrowse link
G Tcf3 transcription factor 3 involved_in ISO
ISS
(PMID:11509675)
GO_REF:0000024
RGD
UniProt
PMID:11509675 GO_REF:0000024 NCBI chr 7:9,931,251...9,952,994 JBrowse link
G Tfrc transferrin receptor involved_in ISS
ISO
GO_REF:0000024
(PMID:26642240)
UniProt
RGD
PMID:26642240 GO_REF:0000024 NCBI chr11:81,668,478...81,690,318 JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 acts_upstream_of_or_within ISO MGI:3029019 (PMID:12855817) RGD PMID:12855817 NCBI chr 9:1,102,559...1,111,023 JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:12447442) RGD PMID:12447442 NCBI chr 8:41,789,557...41,805,903 JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1860885 (PMID:10549626)
Ensembl
RGD
PMID:10549626 GO_REF:0000107 NCBI chr 5:85,161,247...85,174,882 JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (PMID:23857366) RGD PMID:23857366 NCBI chr 8:115,743,407...115,747,523 JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:15240667)
GO_Central
RGD
PMID:15240667 GO_REF:0000033 NCBI chr 7:113,736,046...113,738,523 JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 involved_in ISO (PMID:7749983) RGD PMID:7749983 NCBI chr 5:171,889,134...171,891,824 JBrowse link
G Tnfsf13 TNF superfamily member 13 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:54,400,054...54,403,723 JBrowse link
G Tnfsf13b TNF superfamily member 13b involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:17499850)
(PMID:15240667)
GO_REF:0000033
RGD
GO_Central
PMID:15240667 PMID:17499850 GO_REF:0000033 NCBI chr16:79,462,406...79,492,888 JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 involved_in ISO (PMID:17875758) RGD PMID:17875758 NCBI chr 2:199,699,861...200,042,344 JBrowse link
G Wnt3a Wnt family member 3A acts_upstream_of_or_within ISO (PMID:10933391) RGD PMID:10933391 NCBI chr10:44,533,734...44,577,919 JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:12496423) RGD PMID:12496423 NCBI chr13:76,256,654...76,280,133 JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 acts_upstream_of_or_within ISO (PMID:21255825) RGD PMID:21255825 NCBI chr 5:64,369,495...64,374,711 JBrowse link
G Exosc6 exosome component 6 acts_upstream_of_or_within ISO (PMID:21255825) RGD PMID:21255825 NCBI chr19:39,022,171...39,023,585 JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
ISO
GO_REF:0000024
(PMID:31806351)
UniProt
RGD
PMID:31806351 GO_REF:0000024 NCBI chr 4:120,392,812...120,415,616 JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISS
ISO
GO_REF:0000024
(PMID:28114273)
UniProt
RGD
PMID:28114273 GO_REF:0000024 NCBI chr 1:210,429,672...210,479,042 JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISS
ISO
GO_REF:0000024
(PMID:28114273)
UniProt
RGD
PMID:28114273 GO_REF:0000024 NCBI chr 1:69,099,531...69,107,145 JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:163,846,678...163,859,851 JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (PMID:20671152) RGD PMID:20671152 NCBI chr 4:7,525,132...7,576,659 JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (PMID:23306439), (PMID:23333305), (PMID:23333306) RGD PMID:23306439 PMID:23333305 PMID:23333306 NCBI chr 3:56,963,840...57,017,106 JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA
(PMID:29656893)
GO_REF:0000033
RGD
GO_Central
PMID:29656893 GO_REF:0000033 NCBI chr 3:119,938,695...120,011,068 JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323 JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO
IBA
(PMID:29656893)
GO_REF:0000033
RGD
GO_Central
PMID:29656893 GO_REF:0000033 NCBI chr 2:35,297,255...35,302,071 JBrowse link
G Tfrc transferrin receptor involved_in ISS
ISO
GO_REF:0000024
(PMID:26642240)
UniProt
RGD
PMID:26642240 GO_REF:0000024 NCBI chr11:81,668,478...81,690,318 JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23345425), (PMID:23760478)
(PMID:15077110), (PMID:15159415)
RGD PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 NCBI chr 3:108,166,574...108,270,229 JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109 JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534 JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within ISO (PMID:23241889) RGD PMID:23241889 NCBI chr14:76,833,179...76,911,304 JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO UniProtKB:Q9JK91 (PMID:10430621) RGD PMID:10430621 NCBI chr12:10,676,818...10,701,161 JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:14988498)
AgBase
RGD
PMID:14988498 GO_REF:0000024 NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tnfsf13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in
ISO
IBA
(PMID:14988498)
MGI:3038886 (PMID:14988498)
GO_REF:0000033
RGD
GO_Central
PMID:14988498 GO_REF:0000033 NCBI chr10:54,400,054...54,403,723 JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 involved_in ISO (PMID:12023368) RGD PMID:12023368 NCBI chr 1:201,507,763...201,517,607 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:107187 (PMID:10490661) RGD PMID:10490661 NCBI chr 7:65,365,505...65,382,825 JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:4127920 (PMID:25404367) RGD PMID:25404367 NCBI chr10:65,568,569...65,616,379 JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (PMID:7688139) RGD PMID:7688139 NCBI chr 9:69,660,316...69,689,192 JBrowse link
G Cd40 CD40 molecule acts_upstream_of_or_within ISO (PMID:12882831) RGD PMID:12882831 NCBI chr 3:174,209,113...174,224,592 JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) RGD PMID:12882831 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO MGI:1857191 (PMID:1830926) RGD PMID:1830926 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12882831), (PMID:14988498) RGD PMID:12882831 PMID:14988498 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109 JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534 JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 involved_in ISO (PMID:26744420) RGD PMID:26744420 NCBI chr 1:181,622,698...181,625,024 JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (PMID:26744420) RGD PMID:26744420 NCBI chr 4:7,525,132...7,576,659 JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO UniProtKB:Q9JK91 (PMID:10430621) RGD PMID:10430621 NCBI chr12:10,676,818...10,701,161 JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (PMID:9015183) RGD PMID:9015183 NCBI chr13:52,147,717...52,259,810 JBrowse link
G Tbx21 T-box transcription factor 21 acts_upstream_of_or_within ISO MGI:2180194 (PMID:12882831) RGD PMID:12882831 NCBI chr10:82,578,751...82,595,253 JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:30842412) RGD PMID:30842412 NCBI chr 3:117,861,916...117,882,680 JBrowse link
G Il10 interleukin 10 acts_upstream_of ISO UniProtKB:P60568 (PMID:22962438) RGD PMID:22962438 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il2 interleukin 2 acts_upstream_of ISO UniProtKB:P22301 (PMID:22962438) RGD PMID:22962438 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
IEA
ISS
(PMID:11460154)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:11460154 GO_REF:0000024 GO_REF:0000107 NCBI chr14:84,604,623...84,609,707 JBrowse link
regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 NOT|involved_in ISO (PMID:27010503) RGD PMID:27010503 NCBI chr16:18,076,413...18,082,356 JBrowse link
G Card11 caspase recruitment domain family, member 11 acts_upstream_of_or_within ISO MGI:3039682 (PMID:12867038) RGD PMID:12867038 NCBI chr12:18,735,088...18,872,045 JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (PMID:7795661), (PMID:9028339) RGD PMID:7795661 PMID:9028339 NCBI chr20:47,074,353...47,079,662 JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO MGI:3664438 (PMID:16501569) RGD PMID:16501569 NCBI chr19:34,487,491...34,547,311 JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856334 (PMID:6610701) RGD PMID:6610701 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Ikzf3 IKAROS family zinc finger 3 involved_in ISO (PMID:9806640) RGD PMID:9806640 NCBI chr10:83,460,564...83,553,591 JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:29288206) RGD PMID:29288206 NCBI chr 1:95,299,457...95,324,564 JBrowse link
G Mir150 microRNA 150 acts_upstream_of_or_within ISO MGI:3763431 (PMID:17927961) RGD PMID:17927961 NCBI chr 1:95,605,024...95,605,108 JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 acts_upstream_of_or_within ISO (PMID:15143214) RGD PMID:15143214 NCBI chr 7:116,019,383...116,055,628 JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856074 (PMID:9254656)
Ensembl
RGD
PMID:9254656 GO_REF:0000107 NCBI chr 4:159,212,320...159,237,069 JBrowse link
G Slamf8 SLAM family member 8 involved_in ISO (PMID:11313408) RGD PMID:11313408 NCBI chr13:85,047,729...85,057,571 JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (PMID:23857366) RGD PMID:23857366 NCBI chr 8:115,743,407...115,747,523 JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:27102483)
UniProt
RGD
PMID:27102483 GO_REF:0000024 NCBI chr 6:98,930,705...98,935,748 JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 involved_in ISO (PMID:27102483) RGD PMID:27102483 NCBI chr 6:16,242,622...16,246,662 JBrowse link
regulation of B cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor involved_in ISO
IEA
(PMID:15681594)
GO_REF:0000107
RGD
Ensembl
PMID:15681594 GO_REF:0000107 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Cd22 CD22 molecule involved_in IBA
ISO
GO_REF:0000033
UniProtKB:Q80ZE3 (PMID:20200274)
GO_Central
RGD
PMID:20200274 GO_REF:0000033 NCBI chr 1:95,243,785...95,270,430 JBrowse link
G Ikzf3 IKAROS family zinc finger 3 involved_in ISO (PMID:9806640) RGD PMID:9806640 NCBI chr10:83,460,564...83,553,591 JBrowse link
G Mzb1 marginal zone B and B1 cell-specific protein involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:21093319)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:21093319 GO_REF:0000024 GO_REF:0000033 NCBI chr18:27,513,087...27,515,148 JBrowse link
G Siglec10 sialic acid binding Ig-like lectin 10 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:93,817,301...93,826,376 JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor acts_upstream_of_or_within ISO MGI:4128102 (PMID:21211721) RGD PMID:21211721 NCBI chr 4:120,070,471...120,122,656 JBrowse link
G Mir181b1 microRNA 181b-1 acts_upstream_of_or_within ISO (PMID:18762567) RGD PMID:18762567 NCBI chr13:52,037,228...52,037,337 JBrowse link
G Mir181b2 microRNA 181b-2 acts_upstream_of_or_within ISO (PMID:18762567) RGD PMID:18762567 NCBI chr 3:22,616,948...22,617,035 JBrowse link
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor involved_in ISO (PMID:21518874) RGD PMID:21518874 NCBI chr10:63,103,920...63,140,780 JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (PMID:16275384) RGD PMID:16275384 NCBI chr  X:17,580,380...17,601,181 JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO MGI:3525439 (PMID:11057672) RGD PMID:11057672 NCBI chr19:24,109,963...24,121,977 JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3695433 (PMID:17137798)
Ensembl
RGD
PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068 JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:25310967)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:25310967 GO_REF:0000024 GO_REF:0000107 NCBI chr12:34,684,583...34,718,429 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    immune system process 3112
      regulation of immune system process 1732
        regulation of leukocyte activation 606
          regulation of lymphocyte activation 523
            regulation of B cell activation 147
              negative regulation of B cell activation + 37
              positive regulation of B cell activation + 92
              regulation of B cell differentiation + 37
              regulation of B cell proliferation + 75
              regulation of isotype switching + 41
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        regulation of cellular process 13013
          regulation of cell activation 663
            regulation of leukocyte activation 606
              regulation of lymphocyte activation 523
                regulation of B cell activation 147
                  negative regulation of B cell activation + 37
                  positive regulation of B cell activation + 92
                  regulation of B cell differentiation + 37
                  regulation of B cell proliferation + 75
                  regulation of isotype switching + 41
paths to the root