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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of antigen receptor-mediated signaling pathway
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Accession:GO:0050858 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell.
Synonyms:exact_synonym: down regulation of antigen receptor-mediated signaling pathway;   downregulation of antigen receptor-mediated signaling pathway;   negative regulation of antigen receptor mediated signalling pathway
 narrow_synonym: inhibition of antigen receptor-mediated signaling pathway


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negative regulation of B cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd22 CD22 molecule involved_in ISO
IEA
IBA		 (PMID:24169826), (PMID:26017478)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:24169826 PMID:26017478 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:95,243,785...95,270,430
Ensembl chr 1:86,117,459...86,132,322 		JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:21482706) RGD PMID:21482706 NCBI chr10:100,428,826...100,441,693
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Cd72 Cd72 molecule involved_in ISO
IEA		 (PMID:1711157)
GO_REF:0000107		 RGD
Ensembl		 PMID:1711157 GO_REF:0000107 NCBI chr 5:62,493,155...62,500,779
Ensembl chr 5:57,697,367...57,704,725 		JBrowse link
G Fcgr2b Fc gamma receptor 2B involved_in ISO (PMID:24169826) RGD PMID:24169826 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fcrl5 Fc receptor-like 5 acts_upstream_of_or_within ISO MGI:96055|MGI:96892 (PMID:23509253) RGD PMID:23509253 NCBI chr 2:175,179,630...175,211,180
Ensembl chr 2:172,881,448...172,913,148 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (PMID:28039360) RGD PMID:28039360 NCBI chr10:55,136,043...55,139,106
Ensembl chr10:54,637,455...54,640,650 		JBrowse link
G Lpxn leupaxin involved_in ISO
IEA
IBA		 (PMID:17640867)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:17640867 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:219,353,319...219,387,743
Ensembl chr 1:209,929,202...209,963,084 		JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:30111844) RGD PMID:30111844 NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Plcl2 phospholipase C-like 2 acts_upstream_of_or_within ISO
IEA		 MGI:2679632 (PMID:14517301)
GO_REF:0000107		 RGD
Ensembl		 PMID:14517301 GO_REF:0000107 NCBI chr 9:3,529,117...3,713,712
Ensembl chr 9:3,292,695...3,477,009 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in ISO
IEA		 (PMID:35941532)
GO_REF:0000107		 RGD
Ensembl		 PMID:35941532 GO_REF:0000107 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO
IEA		 (PMID:23589618)
GO_REF:0000107		 RGD
Ensembl		 PMID:23589618 GO_REF:0000107 NCBI chr17:42,048,842...42,060,650
Ensembl chr17:41,620,839...41,632,618 		JBrowse link
G Btnl2 butyrophilin-like 2 acts_upstream_of_or_within ISO (PMID:16751379) RGD PMID:16751379 NCBI chr20:4,492,100...4,505,932
Ensembl chr20:4,489,517...4,503,341 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase involved_in ISO
IEA		 (PMID:38225265)
GO_REF:0000107		 RGD
Ensembl		 PMID:38225265 GO_REF:0000107 NCBI chr 1:254,159,085...254,324,819
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Cblb Cbl proto-oncogene B acts_upstream_of_or_within ISO
IEA		 MGI:2180572 (PMID:14738763)
GO_REF:0000107		 RGD
Ensembl		 PMID:14738763 GO_REF:0000107 NCBI chr11:62,058,829...62,225,904
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Cd160 CD160 molecule involved_in ISO
IEA		 (PMID:18193050)
GO_REF:0000107		 RGD
Ensembl		 PMID:18193050 GO_REF:0000107 NCBI chr 2:187,029,654...187,042,447
Ensembl chr 2:184,340,599...184,375,834 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS		 (PMID:18424730)
GO_REF:0000024		 RGD
UniProt		 PMID:18424730 GO_REF:0000024 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Csk C-terminal Src kinase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISS
ISO		 GO_REF:0000024
(PMID:12883552)		 UniProt
RGD		 PMID:12883552 GO_REF:0000024 NCBI chr 3:98,359,804...98,401,847
Ensembl chr 3:77,904,150...77,946,099 		JBrowse link
G Dusp22 dual specificity phosphatase 22 acts_upstream_of_or_within
involved_in		 ISO (PMID:24714587)
(PMID:38225265)		 RGD PMID:24714587 PMID:38225265 NCBI chr17:33,989,637...34,040,021
Ensembl chr17:33,780,981...33,831,321 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO
IBA		 (PMID:12447358)
GO_REF:0000033		 RGD
GO_Central		 PMID:12447358 GO_REF:0000033 NCBI chr10:87,420,213...87,434,202
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Elf1 E74 like ETS transcription factor 1 acts_upstream_of_or_within ISO
IEA		 MGI:1926074 (PMID:14738763)
GO_REF:0000107		 RGD
Ensembl		 PMID:14738763 GO_REF:0000107 NCBI chr15:61,354,026...61,395,762
Ensembl chr15:54,865,616...54,986,699 		JBrowse link
G Ezr ezrin involved_in ISO
IEA		 (PMID:20551903)
GO_REF:0000107		 RGD
Ensembl		 PMID:20551903 GO_REF:0000107 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Itpripl1 ITPRIP like 1 involved_in ISO (PMID:38614099) RGD PMID:38614099 NCBI chr 3:134,858,316...134,861,241
Ensembl chr 3:114,402,270...114,414,497 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (PMID:18619870) RGD PMID:18619870 NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) RGD PMID:19706535 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035), (PMID:22387553) RGD PMID:16493035 PMID:22387553 NCBI chr 1:78,847,685...78,853,294
Ensembl chr 1:69,805,250...69,810,660 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IEA		 (PMID:38614099)
GO_REF:0000107		 RGD
Ensembl		 PMID:38614099 GO_REF:0000107 NCBI chr 8:109,897,723...109,958,247
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO MGI:2678021 (PMID:12970181) RGD PMID:12970181 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Phpt1 phosphohistidine phosphatase 1 involved_in ISO (PMID:18796614) RGD PMID:18796614 NCBI chr 3:28,791,062...28,792,905 JBrowse link
G Prnp prion protein involved_in ISO
IEA		 (PMID:20145049)
GO_REF:0000107		 RGD
Ensembl		 PMID:20145049 GO_REF:0000107 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22080863)		 UniProt
Ensembl
RGD		 PMID:22080863 GO_REF:0000024 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:18056643) RGD PMID:18056643 NCBI chr 2:194,055,165...194,103,209
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 acts_upstream_of_or_within ISO
IEA		 MGI:1856074 (PMID:9064344)
GO_REF:0000107		 RGD
Ensembl		 PMID:9064344 GO_REF:0000107 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO
IEA		 (PMID:11259588), (PMID:12913111), (PMID:9780142)
(PMID:12913111)
GO_REF:0000107		 RGD
Ensembl		 PMID:9780142 PMID:11259588 PMID:12913111 GO_REF:0000107 NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Pvrig PVR related immunoglobulin domain containing involved_in ISO
IBA
IEA		 (PMID:26755705)
GO_REF:0000033
GO_REF:0000002		 RGD
GO_Central
InterPro		 PMID:26755705 GO_REF:0000002 GO_REF:0000033 NCBI chr12:22,474,441...22,479,191
Ensembl chr12:17,364,080...17,365,280 		JBrowse link
G Sh2d1a SH2 domain containing 1A involved_in ISO
IEA		 (PMID:9774102)
GO_REF:0000107		 RGD
Ensembl		 PMID:9774102 GO_REF:0000107 NCBI chr  X:126,239,191...126,267,425 JBrowse link
G Sla2 Src-like-adaptor 2 involved_in ISO
IEA		 (PMID:11891219)
GO_REF:0000107		 RGD
Ensembl		 PMID:11891219 GO_REF:0000107 NCBI chr 3:165,821,164...165,848,087
Ensembl chr 3:145,368,598...145,382,480 		JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in ISS
ISO		 GO_REF:0000024
(PMID:9285719)		 UniProt
RGD		 PMID:9285719 GO_REF:0000024 NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:107180 (PMID:14738763)		 GO_Central
RGD		 PMID:14738763 GO_REF:0000033 NCBI chr20:9,292,819...9,336,036
Ensembl chr20:9,292,139...9,329,224 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      negative regulation of immune system process 591
        negative regulation of antigen receptor-mediated signaling pathway 39
          negative regulation of B cell receptor signaling pathway 10
          negative regulation of T cell receptor signaling pathway + 30
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        regulation of immune system process 1745
          positive regulation of immune system process 1207
            positive regulation of immune response 833
              activation of immune response 598
                immune response-activating signaling pathway 515
                  immune response-activating cell surface receptor signaling pathway 309
                    antigen receptor-mediated signaling pathway 195
                      regulation of antigen receptor-mediated signaling pathway 73
                        negative regulation of antigen receptor-mediated signaling pathway 39
                          negative regulation of B cell receptor signaling pathway 10
                          negative regulation of T cell receptor signaling pathway + 30
paths to the root