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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta metabolic process
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Accession:GO:0050435 term browser browse the term
Definition:The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).
Synonyms:exact_synonym: beta-amyloid metabolism
 never_in_taxon: NCBITaxon:4751 ! Fungi


show annotations for term's descendants           Sort by:
amyloid-beta metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 acts_upstream_of_or_within ISO MGI:97004 (PMID:21881209), (PMID:25991605) RGD PMID:21881209 PMID:25991605 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Ace angiotensin I converting enzyme involved_in ISO
IEA 		(PMID:18495113), (PMID:19773553)
GO_REF:0000107 		RGD
Ensembl		 PMID:18495113 PMID:19773553 GO_REF:0000107 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Apeh acylaminoacyl-peptide hydrolase involved_in ISO
IEA 		(PMID:17241160)
GO_REF:0000107 		RGD
Ensembl		 PMID:17241160 GO_REF:0000107 NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:108,773,794...108,782,933 		JBrowse link
G Bace1 beta-secretase 1 acts_upstream_of_or_within
involved_in 		IMP
IEA
ISO
IBA
ISS 		GO_REF:0000107
(PMID:25592972)
GO_REF:0000033
(PMID:10677483), (PMID:15080893)
GO_REF:0000024 		Ensembl
RGD
GO_Central
UniProt		 PMID:10677483 PMID:15080893 PMID:25592972 PMID:10531052 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:69771 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bace2 beta-secretase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Becn1 beclin 1 acts_upstream_of_or_within ISO
IEA 		MGI:2683696 (PMID:18497889)
GO_REF:0000107 		RGD
Ensembl		 PMID:18497889 GO_REF:0000107 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Ide insulin degrading enzyme involved_in IMP
IEA
IBA
ISO
ISS 		catabolism
GO_REF:0000107
GO_REF:0000033
(PMID:17613531), (PMID:26968463), (PMID:9830016)
GO_REF:0000024 		Ensembl
GO_Central
RGD
UniProt		 PMID:9830016 PMID:17613531 PMID:26968463 PMID:15749695 PMID:18411275 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:1626704, RGD:2325981 NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Mgat3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase acts_upstream_of_or_within ISS
ISO 		GO_REF:0000024
MGI:1857830 (PMID:25592972) 		UniProt
RGD		 PMID:25592972 GO_REF:0000024 NCBI chr 7:113,614,011...113,640,201
Ensembl chr 7:111,675,730...111,762,026 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in
acts_upstream_of_or_within 		ISS
ISO
IEA 		GO_REF:0000024
MGI:102676 (PMID:12074840), (PMID:25991605)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:12074840 PMID:25991605 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Nat8b N-acetyltransferase 8B involved_in ISO (PMID:19011241) RGD PMID:19011241 NCBI chr 4:119,916,909...119,923,544
Ensembl chr 4:118,359,443...118,363,563 		JBrowse link
G Ncstn nicastrin acts_upstream_of_or_within ISO
IEA 		MGI:2667524 (PMID:17913918)
GO_REF:0000107 		RGD
Ensembl		 PMID:17913918 GO_REF:0000107 NCBI chr13:87,062,827...87,078,839
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO
IEA 		MGI:1930934 (PMID:12684521)
GO_REF:0000107 		RGD
Ensembl		 PMID:12684521 GO_REF:0000107 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:1930939 (PMID:10846187), (PMID:12684521) RGD PMID:10846187 PMID:12684521 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Ren renin IEP RGD PMID:22609375 RGD:6892653 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Unc13a unc-13 homolog A acts_upstream_of_or_within ISO MGI:3051217 (PMID:15123597) RGD PMID:15123597 NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO 		GO_REF:0000024
(PMID:27472885) 		UniProt
RGD		 PMID:27472885 GO_REF:0000024 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Cd36 CD36 molecule involved_in ISO
IBA
IMP 		(PMID:18941241)
GO_REF:0000033 		RGD
GO_Central		 PMID:18941241 PMID:18941241 GO_REF:0000033, RGD:13825436 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd36l1 CD36 molecule like 1 involved_in IBA
IMP 		GO_REF:0000033
PMID:18941241 		GO_Central PMID:18941241 GO_REF:0000033, RGD:13825436 NCBI chr 4:18,316,806...18,357,863
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Ide insulin degrading enzyme involved_in IMP
IEA
ISO 		PMID:18941241
GO_REF:0000107
(PMID:23525105) 		Ensembl
RGD		 PMID:23525105 PMID:18941241 GO_REF:0000107, RGD:13825436 NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO 		GO_REF:0000107
(PMID:22383525) 		Ensembl
RGD		 PMID:22383525 GO_REF:0000107 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G LOC134486712 platelet glycoprotein 4-like involved_in IBA
IMP 		GO_REF:0000033
PMID:18941241 		GO_Central PMID:18941241 GO_REF:0000033, RGD:13825436 NCBI chr 4:18,372,301...18,408,431 JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO
IBA
IEA 		(PMID:23152628), (PMID:24305823)
UniProtKB:P05067|UniProtKB:P49768 (PMID:21289173), (PMID:23152628), (PMID:24305823)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:21289173 PMID:23152628 PMID:24305823 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in ISO
IEA 		(PMID:18289866)
GO_REF:0000107 		RGD
Ensembl		 PMID:18289866 GO_REF:0000107 NCBI chr 3:97,885,373...97,939,366
Ensembl chr 3:77,429,798...77,483,593 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in ISO
IEA
IMP 		UniProtKB:P05067 (PMID:15100223), (PMID:24825898)
GO_REF:0000107
PMID:18941241 		RGD
Ensembl		 PMID:15100223 PMID:24825898 PMID:18941241 GO_REF:0000107, RGD:13825436 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IEA 		(PMID:33097708)
GO_REF:0000107
(PMID:30617257), (PMID:31134514), (PMID:31980586) 		RGD
Ensembl		 PMID:30617257 PMID:31134514 PMID:31980586 PMID:33097708 GO_REF:0000107 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS 		(PMID:26260791)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in IMP PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597) RGD PMID:12297508 PMID:12763021 PMID:25043039 PMID:26280335 PMID:27608597 NCBI chr 2:186,123,023...186,130,886
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit involved_in
acts_upstream_of_or_within 		ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597)
MGI:1202717|MGI:1891700 (PMID:16371134) 		RGD PMID:12763021 PMID:16371134 PMID:27608597 NCBI chr 8:76,310,380...76,334,146
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO
IEA 		(PMID:27992182)
GO_REF:0000107 		RGD
Ensembl		 PMID:27992182 GO_REF:0000107 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Bace1 beta-secretase 1 involved_in ISO
IEA 		(PMID:24352696)
GO_REF:0000107 		RGD
Ensembl		 PMID:24352696 GO_REF:0000107 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Ncstn nicastrin involved_in
acts_upstream_of_or_within 		ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
MGI:1202717|MGI:3522097 (PMID:16371134)
UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597) 		UniProt
Ensembl
RGD		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:25043039 PMID:26280335 More... GO_REF:0000024 GO_REF:0000107 NCBI chr13:87,062,827...87,078,839
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA
ISS 		UniProtKB:P05067 (PMID:12297508), (PMID:12763021), (PMID:26280335), (PMID:27608597)
GO_REF:0000107
MGI:1891700|MGI:2149116|MGI:3522097 (PMID:16371134), (PMID:20130175)
GO_REF:0000033
GO_REF:0000024 		RGD
Ensembl
GO_Central
UniProt		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:20130175 PMID:26280335 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO
IEA
IBA 		(PMID:27608597)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:27608597 GO_REF:0000033 GO_REF:0000107 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (PMID:12660785), (PMID:12763021), (PMID:25043039), (PMID:26280335) 		UniProt
Ensembl
RGD		 PMID:12660785 PMID:12763021 PMID:25043039 PMID:26280335 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:94,942,348...94,943,545
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO 		GO_REF:0000024
(PMID:18429932), (PMID:23467355), (PMID:27030769) 		Alzheimers_University_of_Toronto
RGD		 PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA 		(PMID:24154541)
GO_REF:0000107
(PMID:24259049) 		RGD
Ensembl		 PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA 		(PMID:27179792)
GO_REF:0000107 		RGD
Ensembl		 PMID:27179792 GO_REF:0000107 NCBI chr18:24,282,840...24,341,461
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Clu clusterin involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:12047389), (PMID:17412999)
GO_REF:0000107 		Alzheimers_University_of_Toronto
RGD
Ensembl		 PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO
IEA 		(PMID:17553422)
GO_REF:0000107 		RGD
Ensembl		 PMID:17553422 GO_REF:0000107 NCBI chr10:101,324,378...101,342,373
Ensembl chr10:100,825,426...100,844,462 		JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:85,778,267...85,786,553
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA 		RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107 		RGD
Ensembl		 PMID:27277332 GO_REF:0000107 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mir103a1 microRNA 103a-1 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr10:20,748,474...20,748,559
Ensembl chr10:20,244,412...20,244,497 		JBrowse link
G Mir103a2 microRNA 103a-2 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr 3:138,963,227...138,963,312
Ensembl chr 3:118,510,194...118,510,279 		JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:22733824) RGD PMID:22733824 NCBI chr 6:144,306,594...144,306,680
Ensembl chr 6:138,163,595...138,163,681 		JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir16-2 microRNA 16-2 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:153,245,349...153,245,443 		JBrowse link
G Mir186 microRNA 186 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr 2:249,241,650...249,241,735
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Mir24-2 microRNA 24-2 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr19:40,859,455...40,859,562
Ensembl chr19:23,954,683...23,954,790 		JBrowse link
G Mir298 microRNA 298 acts_upstream_of ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:183,470,522...183,470,603
Ensembl chr 3:163,052,291...163,052,372 		JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,618,334...60,618,414
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:109,098,831...109,098,911
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir339 microRNA 339 acts_upstream_of ISO (PMID:24352696) RGD PMID:24352696 NCBI chr12:20,391,395...20,391,490
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir361 microRNA 361 involved_in ISO (PMID:31601077) RGD PMID:31601077 NCBI chr  X:82,438,463...82,438,532
Ensembl chr  X:78,246,206...78,246,275 		JBrowse link
G Mir455 microRNA 455 acts_upstream_of ISO (PMID:25100943), (PMID:31181293) RGD PMID:25100943 PMID:31181293 NCBI chr 5:81,704,834...81,704,911
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within ISO
IEA 		UniProtKB:P05067-4 (PMID:26094765)
GO_REF:0000107 		RGD
Ensembl		 PMID:26094765 GO_REF:0000107 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(PMID:16554819) 		RGD PMID:16554819 PMID:25576397 NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Prnp prion protein involved_in ISO
IEA 		UniProtKB:P12023 (PMID:17573534)
GO_REF:0000107 		RGD
Ensembl		 PMID:17573534 GO_REF:0000107 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA 		(PMID:24305806), (PMID:27853422)
GO_REF:0000107 		RGD
Ensembl		 PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rtn1 reticulon 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:15286784)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:96,499,137...96,719,340
Ensembl chr 6:90,763,216...90,983,436 		JBrowse link
G Rtn2 reticulon 2 involved_in ISO
ISS
IEA 		(PMID:15286784)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:88,063,124...88,076,082
Ensembl chr 1:78,935,104...78,948,069 		JBrowse link
G Rtn3 reticulon 3 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:15286784)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:214,041,838...214,098,644
Ensembl chr 1:204,612,675...204,669,275 		JBrowse link
G Rtn4 reticulon 4 involved_in ISO
ISS
IEA 		(PMID:15286784)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:107,651,001...107,698,610
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO
IEA 		(PMID:18362153), (PMID:19036982)
(PMID:16174740), (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
GO_REF:0000107 		RGD
Ensembl		 PMID:16174740 PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 More... GO_REF:0000107 NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within ISO
IEA 		(PMID:16227578)
GO_REF:0000107 		RGD
Ensembl		 PMID:16227578 GO_REF:0000107 NCBI chr 1:177,363,526...177,662,689
Ensembl chr 1:167,928,972...168,228,226 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in 		ISO
IEA
IMP 		(PMID:22086926)
GO_REF:0000107 		RGD
Ensembl		 PMID:22086926 PMID:22086926 GO_REF:0000107, RGD:14697726 NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541 PMID:24259049 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Casp3 caspase 3 involved_in IDA
IEA
ISO 		PMID:17553422
GO_REF:0000107
(PMID:17553422) 		Ensembl
RGD		 PMID:17553422 PMID:17553422 GO_REF:0000107, RGD:13825190 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P05067 (PMID:20164328) 		Ensembl
RGD		 PMID:20164328 GO_REF:0000107 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:12145324)
GO_REF:0000024 		Ensembl
RGD
Alzheimers_University_of_Toronto		 PMID:12145324 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:112,863,726...112,887,338
Ensembl chr 7:110,983,318...111,006,794 		JBrowse link
G Efna1 ephrin A1 involved_in ISO
IEA 		(PMID:24217950)
GO_REF:0000107 		RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Epha4 Eph receptor A4 involved_in ISO
IEA 		UniProtKB:P20827 (PMID:24217950)
GO_REF:0000107 		RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Gsap gamma-secretase activating protein involved_in ISO
IEA
IBA 		(PMID:20811458)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:20811458 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:14,705,237...14,800,057
Ensembl chr 4:13,813,046...13,907,814 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO UniProtKB:P49841 (PMID:12761548) RGD PMID:12761548 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (PMID:17255335) 		RGD PMID:17255335 PMID:19808651 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01579|UniProtKB:P05067 (PMID:17255335) RGD PMID:17255335 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within ISO
IEA 		(PMID:17098871)
GO_REF:0000107 		RGD
Ensembl		 PMID:17098871 GO_REF:0000107 NCBI chr20:24,514,304...24,688,322
Ensembl chr20:24,515,627...24,689,669 		JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:27277332) RGD PMID:27277332 NCBI chr 9:30,590,697...30,590,780
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
IEA 		(PMID:24577224)
(PMID:22539346), (PMID:24577224)
GO_REF:0000024
GO_REF:0000107 		RGD
Alzheimers_University_of_Toronto
Ensembl		 PMID:22539346 PMID:24577224 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of ISO
IEA 		(PMID:21329555)
GO_REF:0000107 		RGD
Ensembl		 PMID:21329555 GO_REF:0000107 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO
IEA 		(PMID:24305806)
GO_REF:0000107 		RGD
Ensembl		 PMID:24305806 GO_REF:0000107 NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO
IEA 		UniProtKB:P05067-4 (PMID:26094765)
GO_REF:0000107 		RGD
Ensembl		 PMID:26094765 GO_REF:0000107 NCBI chr 7:124,278,881...124,606,146
Ensembl chr 7:122,399,330...122,726,605 		JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO
IEA 		(PMID:14701757)
GO_REF:0000107 		RGD
Ensembl		 PMID:14701757 GO_REF:0000107 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) RGD PMID:17255335 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA
ISO 		GO_REF:0000107
(PMID:25556849) 		Ensembl
RGD		 PMID:25556849 GO_REF:0000107 NCBI chr11:47,360,824...47,479,033
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO UniProtKB:P05067-PRO_0000000092 (PMID:26005850) RGD PMID:26005850 NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO
IEA
ISS 		(PMID:16641999)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:16641999 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:104,991,838...105,026,753 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        amide metabolic process 495
          amyloid-beta metabolic process 79
            amyloid-beta clearance by cellular catabolic process 10
            amyloid-beta formation + 61
paths to the root