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ONTOLOGY REPORT - ANNOTATIONS

Term:prostaglandin E2 9-reductase activity
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Accession:GO:0050221 term browser browse the term
Definition:Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
Synonyms:related_synonym: (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity;   9-keto-prostaglandin E(2) reductase activity;   9-keto-prostaglandin E2 reductase activity;   9-ketoprostaglandin reductase activity;   PGE(2) 9-ketoreductase activity;   PGE(2) 9-oxoreductase activity;   PGE-9-ketoreductase activity;   PGE2 9-ketoreductase activity;   PGE2 9-oxoreductase activity;   PGE2-9-OR;   prostaglandin E 9-ketoreductase activity;   prostaglandin E2-9-oxoreductase activity;   prostaglandin-E(2) 9-oxoreductase activity;   reductase, 15-hydroxy-9-oxoprostaglandin
 xref: EC:1.1.1.189;   MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN;   RHEA:24508;   reactome:R-HSA-2161651 "PGE2 is converted to PGF2a by CBR1"


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prostaglandin E2 9-reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr1 carbonyl reductase 1 enables ISS
ISO		 GO_REF:0000024
(PMID:7005231)		 UniProt
RGD		 PMID:7005231 GO_REF:0000024 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cbr1l1 carbonyl reductase 1 like 1 enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr11:32,876,563...32,884,234
Ensembl chr11:32,857,991...32,895,275 		JBrowse link
G Cbr1l2 carbonyl reductase 1 like 2 enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr11:32,892,640...32,895,277
Ensembl chr11:32,857,991...32,895,275 		JBrowse link
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  molecular_function 21086
    catalytic activity 6121
      oxidoreductase activity 868
        oxidoreductase activity, acting on CH-OH group of donors 165
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 156
            prostaglandin E2 9-reductase activity 3
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