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ONTOLOGY REPORT - ANNOTATIONS

Term:sperm capacitation
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Accession:GO:0048240 term browser browse the term
Definition:A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
Comment:Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract.
Synonyms:related_synonym: sperm activation


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sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase involved_in ISO
IEA
IBA 		(PMID:26989199)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:26989199 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:133,217,375...133,299,061 		JBrowse link
G Bsph1 binder of sperm protein homolog 1 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:22539676) 		GO_Central
Ensembl
RGD		 PMID:22539676 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:83,549,565...83,585,706
Ensembl chr 1:74,411,200...74,450,120 		JBrowse link
G C2cd6 C2 calcium dependent domain containing 6 involved_in
acts_upstream_of_or_within 		ISO (PMID:34998468)
(PMID:34919125) 		RGD PMID:34919125 PMID:34998468 NCBI chr 9:67,929,069...68,024,993
Ensembl chr 9:60,434,925...60,530,806 		JBrowse link
G Cabyr calcium binding tyrosine phosphorylation regulated involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:4,166,790...4,178,570
Ensembl chr18:3,892,132...3,903,840 		JBrowse link
G Catsper2 cation channel, sperm associated 2 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:2683843 (PMID:14657366) 		GO_Central
RGD		 PMID:14657366 GO_REF:0000033 NCBI chr 3:128,822,387...128,842,501
Ensembl chr 3:108,368,668...108,388,050 		JBrowse link
G Catsper3 cation channel, sperm associated 3 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
MGI:3694352 (PMID:17227845) 		GO_Central
Ensembl
RGD		 PMID:17227845 GO_REF:0000033 GO_REF:0000107 NCBI chr17:8,820,738...8,846,063
Ensembl chr17:8,815,561...8,840,864 		JBrowse link
G Catsper4 cation channel, sperm associated 4 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
MGI:3694354 (PMID:17227845) 		GO_Central
Ensembl
RGD		 PMID:17227845 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:151,711,415...151,731,083
Ensembl chr 5:146,427,683...146,446,942 		JBrowse link
G Catsperd cation channel sperm associated auxiliary subunit delta involved_in ISS
ISO
IBA 		GO_REF:0000024
(PMID:21224844)
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:21224844 GO_REF:0000024 GO_REF:0000033 NCBI chr 9:1,546,903...1,585,470
Ensembl chr 9:1,460,001...1,498,344 		JBrowse link
G Catspere catsper channel auxiliary subunit epsilon involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:92,331,826...92,487,215
Ensembl chr13:89,819,244...89,950,979 		JBrowse link
G Catsperz catsper channel auxiliary subunit zeta involved_in ISO (PMID:28226241), (PMID:31056283) RGD PMID:28226241 PMID:31056283 NCBI chr 1:213,544,032...213,547,326 JBrowse link
G Cftr CF transmembrane conductance regulator involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:21976599) 		Ensembl
UniProt
RGD		 PMID:21976599 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Dld dihydrolipoamide dehydrogenase acts_upstream_of_or_within ISO
IEA 		(PMID:15888450)
GO_REF:0000107 		RGD
Ensembl		 PMID:15888450 GO_REF:0000107 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Efcab9 EF-hand calcium binding domain 9 involved_in IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:31056283) 		GO_Central
Ensembl
RGD		 PMID:31056283 GO_REF:0000033 GO_REF:0000107 NCBI chr10:17,611,408...17,616,566
Ensembl chr10:17,107,123...17,112,289 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in
acts_upstream_of_or_within 		ISS
ISO
IEA 		GO_REF:0000024
(PMID:19342015), (PMID:21302280)
MGI:2665512 (PMID:16371590)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:16371590 PMID:19342015 PMID:21302280 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:10,032,040...10,040,263
Ensembl chr 7:9,381,361...9,389,585 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 acts_upstream_of_or_within ISO (PMID:16183867) RGD PMID:16183867 NCBI chr12:44,946,307...44,967,890
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in IEA
ISO 		GO_REF:0000107
(PMID:19560455) 		Ensembl
RGD		 PMID:19560455 GO_REF:0000107 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ropn1 rhophilin associated tail protein 1 involved_in
acts_upstream_of_or_within 		ISS
IEA
ISO
IBA 		GO_REF:0000024
GO_REF:0000107
MGI:4144733 (PMID:23303679)
GO_REF:0000033 		UniProt
Ensembl
RGD
GO_Central		 PMID:23303679 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr11:79,603,053...79,632,344
Ensembl chr11:66,097,856...66,127,148 		JBrowse link
G Ropn1l rhophilin associated tail protein 1-like acts_upstream_of_or_within ISO
IEA 		MGI:4143866 (PMID:23303679)
GO_REF:0000107 		RGD
Ensembl		 PMID:23303679 GO_REF:0000107 NCBI chr 2:84,153,529...84,164,216
Ensembl chr 2:82,441,891...82,453,485 		JBrowse link
G Semg1 semenogelin 1 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:17123940) 		GO_Central
RGD		 PMID:17123940 GO_REF:0000033 NCBI chr 3:173,329,413...173,332,261
Ensembl chr 3:152,910,034...152,912,882 		JBrowse link
G Septin4 septin 4 acts_upstream_of_or_within ISO MGI:3574368 (PMID:15737931) RGD PMID:15737931 NCBI chr10:72,863,969...72,888,018
Ensembl chr10:72,366,873...72,390,768 		JBrowse link
G Slc22a14 solute carrier family 22, member 14 acts_upstream_of_or_within ISO
IEA 		MGI:2137691 (PMID:27811987)
GO_REF:0000107 		RGD
Ensembl		 PMID:27811987 GO_REF:0000107 NCBI chr 8:127,772,275...127,794,222
Ensembl chr 8:118,895,259...118,908,255 		JBrowse link
G Slc26a3 solute carrier family 26 member 3 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:21976599) 		UniProt
Ensembl
RGD		 PMID:21976599 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:53,751,415...53,792,300
Ensembl chr 6:48,023,892...48,064,772 		JBrowse link
G Slc26a6 solute carrier family 26 member 6 involved_in ISO
IEA 		(PMID:21976599)
GO_REF:0000107 		RGD
Ensembl		 PMID:21976599 GO_REF:0000107 NCBI chr 8:118,438,110...118,448,271
Ensembl chr 8:109,559,642...109,569,778 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 acts_upstream_of_or_within ISO (PMID:22228629) RGD PMID:22228629 NCBI chr18:36,121,626...36,133,596
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Svs3a seminal vesicle secretory protein 3A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:173,377,977...173,383,302
Ensembl chr 3:152,961,706...152,963,922 		JBrowse link
G Svs3b seminal vesicle secretory protein 3B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:173,349,024...173,351,883
Ensembl chr 3:152,929,645...152,931,919 		JBrowse link
negative regulation of sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paep progestagen associated endometrial protein involved_in ISO (PMID:15883155) RGD PMID:15883155 NCBI chr 3:28,929,252...28,932,592
Ensembl chr 3:8,531,138...8,534,430 		JBrowse link
positive regulation of flagellated sperm motility involved in capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in ISO
IEA 		(PMID:23765988)
GO_REF:0000107 		RGD
Ensembl		 PMID:23765988 GO_REF:0000107 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Defb1 defensin beta 1 involved_in ISO
ISS 		(PMID:25122636)
GO_REF:0000024 		RGD
UniProt		 PMID:25122636 GO_REF:0000024 NCBI chr16:77,001,326...77,016,068
Ensembl chr16:70,298,863...70,313,604 		JBrowse link
G Iqcf1 IQ motif containing F1 involved_in ISO
IEA 		(PMID:25380116)
GO_REF:0000107 		RGD
Ensembl		 PMID:25380116 GO_REF:0000107 NCBI chr 8:116,008,081...116,011,950
Ensembl chr 8:107,130,704...107,133,249 		JBrowse link
G Rnase9 ribonuclease A family member 9 acts_upstream_of_or_within ISO MGI:5637811 (PMID:24719258) RGD PMID:24719258 NCBI chr15:26,733,051...26,736,605
Ensembl chr15:24,259,525...24,263,079 		JBrowse link
positive regulation of sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam7 ADAM metallopeptidase domain 7 involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:26246218) 		Ensembl
UniProt
RGD		 PMID:26246218 GO_REF:0000024 GO_REF:0000107 NCBI chr15:47,009,176...47,057,581
Ensembl chr15:42,833,796...42,882,201 		JBrowse link
G Tmprss12 transmembrane serine protease 12 involved_in ISO (PMID:35547804) RGD PMID:35547804 NCBI chr 7:133,311,839...133,324,620
Ensembl chr 7:131,433,484...131,445,791 		JBrowse link
regulation of sperm capacitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tcp11 t-complex 11 involved_in ISS
ISO
IBA 		GO_REF:0000024
(PMID:9322250), (PMID:9820206)
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:9322250 PMID:9820206 GO_REF:0000024 GO_REF:0000033 NCBI chr20:6,128,001...6,140,152
Ensembl chr20:6,126,269...6,136,055 		JBrowse link
G Tcp11x2 t-complex 11 family, X-linked 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:102,884,405...103,432,445
Ensembl chr  X:98,591,189...98,640,763 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cellular process involved in reproduction in multicellular organism 515
        sperm capacitation 35
          negative regulation of sperm capacitation 1
          positive regulation of flagellated sperm motility involved in capacitation 4
          positive regulation of sperm capacitation 2
          regulation of sperm capacitation + 5
Path 2
Term Annotations click to browse term
  biological_process 20543
    reproductive process 1978
      sexual reproduction 1256
        gamete generation 1012
          male gamete generation 759
            spermatogenesis 737
              spermatid differentiation 296
                spermatid development 286
                  sperm capacitation 35
                    negative regulation of sperm capacitation 1
                    positive regulation of flagellated sperm motility involved in capacitation 4
                    positive regulation of sperm capacitation 2
                    regulation of sperm capacitation + 5
paths to the root