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ONTOLOGY REPORT - ANNOTATIONS

Term:vascular endothelial growth factor receptor signaling pathway
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Accession:GO:0048010 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Comment:In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
Synonyms:exact_synonym: VEGF receptor signaling pathway;   VEGF receptor signalling pathway;   VEGFR signaling pathway
 xref: Reactome:R-HSA-194138 "Signaling by VEGF"
 never_in_taxon: NCBITaxon:2 ! Bacteria;   NCBITaxon:2157 ! Archaea;   NCBITaxon:4751 ! Fungi
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


show annotations for term's descendants           Sort by:
vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO
IEA		 (PMID:21245381)
GO_REF:0000107		 RGD
Ensembl		 PMID:21245381 GO_REF:0000107 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IMP RGD PMID:14693680 RGD:1580560 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of ISO MGI:3629660 (PMID:17560563) RGD PMID:17560563 NCBI chr 2:52,533,939...52,610,980
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf18 fibroblast growth factor 18 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2178751 (PMID:17014841)		 Ensembl
RGD		 PMID:17014841 GO_REF:0000107 NCBI chr10:18,210,240...18,241,929
Ensembl chr10:17,706,174...17,736,818 		JBrowse link
G Fgf9 fibroblast growth factor 9 acts_upstream_of ISO MGI:2135961 (PMID:17544391) RGD PMID:17544391 NCBI chr15:36,325,552...36,369,995
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:11312102), (PMID:1312256), (PMID:9299537)
MGI:1934260 (PMID:9689083)
GO_REF:0000033		 RGD
GO_Central		 PMID:1312256 PMID:9299537 PMID:9689083 PMID:11312102 GO_REF:0000033 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in
acts_upstream_of_or_within		 IMP
ISO
IBA		 (PMID:11532940), (PMID:19779139)
(PMID:9012504)
GO_REF:0000033		 RGD
GO_Central		 PMID:9012504 PMID:11532940 PMID:19779139 PMID:11683876 GO_REF:0000033, RGD:727326 NCBI chr10:34,414,834...34,455,878
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G Foxc1 forkhead box C1 acts_upstream_of_or_within ISO MGI:1347481 (PMID:16678147) RGD PMID:16678147 NCBI chr17:32,840,119...32,844,100
Ensembl chr17:32,633,142...32,634,803 		JBrowse link
G Foxc2 forkhead box C2 acts_upstream_of_or_within ISO MGI:1347466 (PMID:16678147) RGD PMID:16678147 NCBI chr19:66,094,718...66,097,420
Ensembl chr19:49,185,662...49,188,737 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 involved_in ISO
IEA		 (PMID:18440775)
GO_REF:0000107		 RGD
Ensembl		 PMID:18440775 GO_REF:0000107 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Kdr kinase insert domain receptor involved_in
acts_upstream_of_or_within		 IMP
ISS
ISO
IEA		 GO_REF:0000024
(PMID:8356051)
(PMID:10102632), (PMID:11387210), (PMID:21885851), (PMID:23529610)
GO_REF:0000117		 UniProt
RGD		 PMID:8356051 PMID:10102632 PMID:11387210 PMID:21885851 PMID:23529610 More... GO_REF:0000024 GO_REF:0000117, RGD:729081, RGD:2292019, RGD:2301848 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in ISO
IEA		 (PMID:18440775)
GO_REF:0000107		 RGD
Ensembl		 PMID:18440775 GO_REF:0000107 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 involved_in ISO
IBA		 (PMID:18440775)
GO_REF:0000033		 RGD
GO_Central		 PMID:18440775 GO_REF:0000033 NCBI chr13:45,066,027...45,112,326
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Nrp1 neuropilin 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:21245381)
MGI:2450311|MGI:3512101 (PMID:12852851)
(PMID:23639442)
GO_REF:0000033		 RGD
GO_Central		 PMID:12852851 PMID:21245381 PMID:23639442 GO_REF:0000033 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Pgf placental growth factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Prkd1 protein kinase D1 involved_in ISO UniProtKB:Q9BZL6 (PMID:18059339), (PMID:18440775), (PMID:20497126) RGD PMID:18059339 PMID:18440775 PMID:20497126 NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Prkd2 protein kinase D2 involved_in ISO UniProtKB:Q15139 (PMID:18059339), (PMID:18440775), (PMID:20497126) RGD PMID:18059339 PMID:18440775 PMID:20497126 NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:77,513,986...77,542,376 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISO (PMID:21245381)
(PMID:17698736)		 RGD PMID:17698736 PMID:21245381 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Sulf1 sulfatase 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16778174)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16778174 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:11,145,950...11,308,622
Ensembl chr 5:6,362,911...6,525,584 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in IMP
ISO
IBA		 (PMID:23639442), (PMID:31915155)
GO_REF:0000033
(PMID:1312256), (PMID:18059339), (PMID:18440775), (PMID:20497126), (PMID:21245381), (PMID:7929439)		 RGD
GO_Central		 PMID:1312256 PMID:7929439 PMID:18059339 PMID:18440775 PMID:20497126 More... GO_REF:0000033, RGD:2301848 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfb vascular endothelial growth factor B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:204,172,225...204,177,944 		JBrowse link
G Vegfc vascular endothelial growth factor C involved_in
acts_upstream_of_or_within		 ISO
ISS
IBA		 (PMID:23878260)
GO_REF:0000024
GO_REF:0000033
MGI:95561 (PMID:9012504), (PMID:9247316)
(PMID:24552833)		 RGD
UniProt
GO_Central		 PMID:9012504 PMID:9247316 PMID:23878260 PMID:24552833 GO_REF:0000024 GO_REF:0000033 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vegfd vascular endothelial growth factor D involved_in
acts_upstream_of_or_within		 IMP
IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
UniProtKB:P35916 (PMID:11574540)		 Ensembl
GO_Central
RGD		 PMID:11574540 PMID:11683876 GO_REF:0000033 GO_REF:0000107, RGD:727326 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:30,074,163...30,108,295 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:23529610) RGD PMID:23529610 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
negative regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadm4 cell adhesion molecule 4 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:25893857)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:25893857 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:80,075,163...80,097,423
Ensembl chr 1:80,075,202...80,097,423 		JBrowse link
G Cnmd chondromodulin acts_upstream_of_or_within ISO MGI:2448465 (PMID:16980969) RGD PMID:16980969 NCBI chr15:55,041,548...55,066,297
Ensembl chr15:55,041,561...55,066,297 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19033661)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19033661 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Emilin1 elastin microfibril interfacer 1 involved_in ISO (PMID:25056700) RGD PMID:25056700 NCBI chr 6:31,175,919...31,183,657
Ensembl chr 6:25,445,298...25,463,698 		JBrowse link
G Epn2 epsin 2 involved_in ISO
IEA		 (PMID:28717225)
GO_REF:0000107		 RGD
Ensembl		 PMID:28717225 GO_REF:0000107 NCBI chr10:46,697,238...46,759,128
Ensembl chr10:46,197,785...46,259,642 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate involved_in ISO
IEA		 (PMID:18977327)
GO_REF:0000107		 RGD
Ensembl		 PMID:18977327 GO_REF:0000107 NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835 		JBrowse link
G Hhex hematopoietically expressed homeobox involved_in IDA
ISO		 PMID:15016828
(PMID:12588764)		 RGD PMID:12588764 PMID:15016828 RGD:8554322 NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:235,190,455...235,196,042 		JBrowse link
G Mir200c microRNA 200c acts_upstream_of ISO (PMID:24205206) RGD PMID:24205206 NCBI chr 4:159,209,965...159,210,033 JBrowse link
G Mmrn1 multimerin 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:89,875,408...89,950,814
Ensembl chr 4:89,903,174...89,950,474 		JBrowse link
G Mmrn2 multimerin 2 involved_in ISO
IBA		 (PMID:22020326)
GO_REF:0000033		 RGD
GO_Central		 PMID:22020326 GO_REF:0000033 NCBI chr16:9,712,181...9,733,653
Ensembl chr16:9,705,892...9,727,405 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase involved_in ISS
ISO		 GO_REF:0000024
(PMID:15060076)		 UniProt
RGD		 PMID:15060076 GO_REF:0000024 NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:73,383,695...73,468,951 		JBrowse link
G Pdcd6 programmed cell death 6 involved_in ISO (PMID:21893193) RGD PMID:21893193 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO UniProtKB:P97333 (PMID:23639442) RGD PMID:23639442 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vegfa vascular endothelial growth factor A involved_in IEA
ISO		 GO_REF:0000107
(PMID:31915155)		 Ensembl
RGD		 PMID:31915155 GO_REF:0000107 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
positive regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:3629660 (PMID:17560563) RGD PMID:17560563 NCBI chr 2:52,533,939...52,610,980
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf18 fibroblast growth factor 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2178751 (PMID:17014841)		 Ensembl
RGD		 PMID:17014841 GO_REF:0000107 NCBI chr10:18,210,240...18,241,929
Ensembl chr10:17,706,174...17,736,818 		JBrowse link
G Fgf9 fibroblast growth factor 9 acts_upstream_of_or_within ISO MGI:2135961 (PMID:17544391) RGD PMID:17544391 NCBI chr15:36,325,552...36,369,995
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Grb10 growth factor receptor bound protein 10 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15060076)		 UniProt
Ensembl
RGD		 PMID:15060076 GO_REF:0000024 GO_REF:0000107 NCBI chr14:90,708,653...90,816,399
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2386649|MGI:2386679 (PMID:11691837)		 Ensembl
RGD		 PMID:11691837 GO_REF:0000107 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Mir10a microRNA 10a involved_in ISO RNAcentral:URS000058760A_9606 (PMID:22955733) RGD PMID:22955733 NCBI chr10:81,779,709...81,779,818
Ensembl chr10:81,283,171...81,283,280 		JBrowse link
G Mir10b microRNA 10b involved_in ISO RNAcentral:URS000016D2D4_9606 (PMID:22955733) RGD PMID:22955733 NCBI chr 3:59,628,438...59,628,546
Ensembl chr 3:59,628,438...59,628,546 		JBrowse link
G Mir1224 microRNA 1224 involved_in ISO (PMID:28717225) RGD PMID:28717225 NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986 		JBrowse link
G Mir296 microRNA 296 involved_in ISO (PMID:18977327) RGD PMID:18977327 NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915 		JBrowse link
G Mt3 metallothionein 3 involved_in ISO
ISS		 (PMID:18295594)
GO_REF:0000024		 RGD
UniProt		 PMID:18295594 GO_REF:0000024 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Prkcb protein kinase C, beta involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:11805327)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:11805327 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkd2 protein kinase D2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19001381)		 UniProt
RGD		 PMID:19001381 GO_REF:0000024 NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:77,513,986...77,542,376 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (PMID:21385766) RGD PMID:21385766 NCBI chr11:24,067,869...25,108,694
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G Vegfb vascular endothelial growth factor B involved_in ISO (PMID:18259607) RGD PMID:18259607 NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:204,172,225...204,177,944 		JBrowse link
regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19144989)		 Ensembl
RGD		 PMID:19144989 GO_REF:0000107 NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Fzd4 frizzled class receptor 4 acts_upstream_of_or_within ISO MGI:2387667 (PMID:16093361) RGD PMID:16093361 NCBI chr 1:152,692,507...152,701,372
Ensembl chr 1:143,280,065...143,285,724 		JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327 		JBrowse link
G Myof myoferlin involved_in ISO (PMID:17702744) RGD PMID:17702744 NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:235,673,666...235,822,334 		JBrowse link
G Nrp1 neuropilin 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Tmem204 transmembrane protein 204 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:95561|MGI:96683 (PMID:20439428)		 GO_Central
RGD		 PMID:20439428 GO_REF:0000033 NCBI chr10:14,076,518...14,104,849
Ensembl chr10:14,076,519...14,101,920 		JBrowse link
G Vegfc vascular endothelial growth factor C IMP RGD PMID:11683876 RGD:727326 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vegfd vascular endothelial growth factor D IMP RGD PMID:11683876 RGD:727326 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:30,074,163...30,108,295 		JBrowse link
vascular endothelial growth factor receptor-1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alk ALK receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 6:28,631,431...29,351,321
Ensembl chr 6:22,880,625...23,598,034 		JBrowse link
G Axl Axl receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr13:84,726,412...84,851,032
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Egfr epidermal growth factor receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Epha1 Eph receptor A1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:71,246,409...71,260,846 		JBrowse link
G Epha2 Eph receptor A2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Epha3 Eph receptor A3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:1,140,985...1,473,900 		JBrowse link
G Epha4 Eph receptor A4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Epha5 EPH receptor A5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317 		JBrowse link
G Epha6 Eph receptor A6 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:53,226,784...54,178,120
Ensembl chr11:39,757,181...40,698,311 		JBrowse link
G Epha7 Eph receptor A7 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112 		JBrowse link
G Epha8 Eph receptor A8 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399 		JBrowse link
G Ephb1 Eph receptor B1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:111,386,432...111,823,759
Ensembl chr 8:102,507,549...102,944,839 		JBrowse link
G Ephb2 Eph receptor B2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Ephb3 Eph receptor B3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:79,840,668...79,859,370 		JBrowse link
G Ephb4 EPH receptor B4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15952180)		 Ensembl
RGD		 PMID:15952180 GO_REF:0000107 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:34,414,834...34,455,878
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Insr insulin receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Insrr insulin receptor-related receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:175,553,244...175,572,676
Ensembl chr 2:173,255,414...173,274,800 		JBrowse link
G Kdr kinase insert domain receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Ltk leukocyte receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:106,734,675...106,741,552
Ensembl chr 3:106,734,676...106,743,369 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:136,391,936...136,498,366
Ensembl chr 3:115,939,351...116,046,554 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mst1r macrophage stimulating 1 receptor involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:117,471,928...117,491,059
Ensembl chr 8:108,597,299...108,612,455 		JBrowse link
G Musk muscle associated receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:77,853,560...77,967,653
Ensembl chr 5:73,058,121...73,171,932 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Ret ret proto-oncogene involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:31,975,328...32,126,675
Ensembl chr20:31,432,637...31,583,865 		JBrowse link
G Tek TEK receptor tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:132,000,013...132,019,658
Ensembl chr 5:132,000,015...132,019,592 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:127,231,468...127,254,806
Ensembl chr 3:106,777,635...106,797,142 		JBrowse link
vascular endothelial growth factor receptor-2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec14a C-type lectin domain containing 14A involved_in
acts_upstream_of_or_within_negative_effect		 ISO (PMID:27991863)
MGI:6404416 (PMID:27991863)		 RGD PMID:27991863 NCBI chr 6:81,616,414...81,619,556
Ensembl chr 6:75,881,473...75,884,612 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19033661)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19033661 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Kdr kinase insert domain receptor involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:15215251), (PMID:24205206)		 Ensembl
UniProt
RGD		 PMID:15215251 PMID:24205206 GO_REF:0000024 GO_REF:0000107 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Pdcd6 programmed cell death 6 involved_in ISO (PMID:21893193) RGD PMID:21893193 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:35027734)		 UniProt
Ensembl
RGD		 PMID:35027734 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO
IEA		 (PMID:23688497)
GO_REF:0000107		 RGD
Ensembl		 PMID:23688497 GO_REF:0000107 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
vascular endothelial growth factor receptor-3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec14a C-type lectin domain containing 14A involved_in
acts_upstream_of_or_within_positive_effect		 ISO (PMID:27991863)
MGI:6404416 (PMID:27991863)		 RGD PMID:27991863 NCBI chr 6:81,616,414...81,619,556
Ensembl chr 6:75,881,473...75,884,612 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      signal transduction 7251
        cell surface receptor signaling pathway 2882
          enzyme-linked receptor protein signaling pathway 1062
            cell surface receptor protein tyrosine kinase signaling pathway 671
              vascular endothelial growth factor receptor signaling pathway 98
                negative regulation of vascular endothelial growth factor receptor signaling pathway 13
                positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 1
                positive regulation of vascular endothelial growth factor receptor signaling pathway 14
                regulation of vascular endothelial growth factor receptor signaling pathway + 35
                vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment 0
                vascular endothelial growth factor receptor-1 signaling pathway 48
                vascular endothelial growth factor receptor-2 signaling pathway 6
                vascular endothelial growth factor receptor-3 signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 20536
    biological regulation 13822
      regulation of biological process 13376
        signaling 7809
          signal transduction 7251
            cell surface receptor signaling pathway 2882
              enzyme-linked receptor protein signaling pathway 1062
                cell surface receptor protein tyrosine kinase signaling pathway 671
                  vascular endothelial growth factor receptor signaling pathway 98
                    negative regulation of vascular endothelial growth factor receptor signaling pathway 13
                    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 1
                    positive regulation of vascular endothelial growth factor receptor signaling pathway 14
                    regulation of vascular endothelial growth factor receptor signaling pathway + 35
                    vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment 0
                    vascular endothelial growth factor receptor-1 signaling pathway 48
                    vascular endothelial growth factor receptor-2 signaling pathway 6
                    vascular endothelial growth factor receptor-3 signaling pathway 1
paths to the root