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ONTOLOGY REPORT - ANNOTATIONS


Term:Delta4-3-oxosteroid 5beta-reductase activity
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Accession:GO:0047787 term browser browse the term
Definition:Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Synonyms:exact_synonym: delta4-3-oxosteroid 5-beta-reductase activity
 narrow_synonym: cholestenone 5-beta-reductase activity;   cholestenone 5b-reductase activity;   cortisone b-reductase activity;   cortisone beta-reductase activity
 broad_synonym: 5-beta-reductase activity
 related_synonym: 3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity;   3-oxo-Delta(4)-steroid 5-beta-reductase activity;   3-oxo-delta4-steroid 5beta-reductase activity;   4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity;   5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity;   5beta-reductase activity;   androstenedione 5-beta-reductase activity;   androstenedione 5beta-reductase activity;   cholestenone 5beta-reductase activity;   cortisone 5-beta-reductase activity;   cortisone 5beta-reductase activity;   cortisone delta(4)-5-beta-reductase activity;   cortisone delta4-5beta-reductase activity;   delta(4)-3-ketosteroid 5-beta-reductase activity;   delta(4)-5-beta-reductase activity;   delta(4)-hydrogenase activity;   delta4-3-ketosteroid 5beta-reductase activity;   delta4-5beta-reductase activity;   delta4-hydrogenase activity;   steroid 5-beta-reductase activity;   steroid 5beta-reductase activity;   testosterone 5-beta-reductase activity;   testosterone 5beta-reductase activity
 alt_id: GO:0047752
 xref: EC:1.3.1.3;   MetaCyc:RXN-23672;   RHEA:54412



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Delta4-3-oxosteroid 5beta-reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 enables ISO (PMID:16983398) RGD PMID:16983398 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 enables IEA GO_REF:0000002
GO_REF:0000003
InterPro
UniProt
GO_REF:0000002 GO_REF:0000003 NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:66,154,248...66,186,372
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  molecular_function 21088
    catalytic activity 6122
      oxidoreductase activity 868
        oxidoreductase activity, acting on the CH-CH group of donors 64
          oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 35
            enone reductase activity 5
              Delta4-3-oxosteroid 5beta-reductase activity 2
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