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ONTOLOGY REPORT - ANNOTATIONS

Term:15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
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Accession:GO:0047020 term browser browse the term
Definition:Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate.
Synonyms:broad_synonym: NADP-dependent 15-hydroxyprostaglandin dehydrogenase;   NADP-linked 15-hydroxyprostaglandin dehydrogenase;   NADP-specific 15-hydroxyprostaglandin dehydrogenase
 related_synonym: (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity;   15-hydroxy PGD2 dehydrogenase activity;   15-hydroxyprostaglandin dehydrogenase (NADP);   NADP-PGD2 dehydrogenase activity;   NADP-linked prostaglandin D2 dehydrogenase activity;   dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate);   dehydrogenase, prostaglandin D2;   prostaglandin D2 dehydrogenase activity;   prostaglandin-D 15-dehydrogenase (NADP);   prostaglandin-D 15-dehydrogenase (NADP+) activity
 xref: EC:1.1.1.196;   MetaCyc:1.1.1.196-RXN;   RHEA:20744


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15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 enables ISO (PMID:22170488) RGD PMID:22170488 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Cbr1 carbonyl reductase 1 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
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  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity 2
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