ONTOLOGY REPORT - ANNOTATIONS
Term: symbiont entry into host cell
Accession: GO:0046718
browse the term
Definition: The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell.
Comment: Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location.
Synonyms: narrow_synonym: entry of virus into host cell; phage translocation; viral entry into host cell; viral penetration; virion penetration; virion penetration into host cell; virus entry into host cell
alt_id: GO:0019063
xref: VZ:936 "Virus entry"
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Ace2
angiotensin converting enzyme 2
involved_in acts_upstream_of_positive_effect
IEA ISO
GO_REF:0000107 (PMID:33163980) (PMID:16051304), (PMID:33163980)
Ensembl RGD
PMID:16051304 PMID:33163980
GO_REF:0000107
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Avp
arginine vasopressin
involved_in
ISO
(PMID:33713620)
RGD
PMID:33713620
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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Avpr1b
arginine vasopressin receptor 1B
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792
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Axl
Axl receptor tyrosine kinase
involved_in
ISO
(PMID:21047970)
RGD
PMID:21047970
NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
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Cd209d
CD209d molecule
involved_in
ISO
(PMID:24623090)
RGD
PMID:24623090
NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171
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Cd300ld
Cd300 molecule-like family member D
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:100,082,957...100,115,853
Ensembl chr10:100,083,490...100,115,821
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Cd300lf
Cd300 molecule-like family member F
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041
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Cd55
CD55 molecule (Cromer blood group)
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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Cd81
Cd81 molecule
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
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Cldn1
claudin 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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Cldn6
claudin 6
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:12,710,302...12,713,987
Ensembl chr10:12,709,960...12,715,973
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Clec4g
C-type lectin domain family 4, member G
involved_in
ISO
(PMID:16051304), (PMID:24623090)
RGD
PMID:16051304 PMID:24623090
NCBI chr12:1,780,370...1,785,027
Ensembl chr12:1,780,371...1,784,985
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Clec4m
C-type lectin domain family 4 member M
involved_in
ISO
(PMID:15479853), (PMID:24623090), (PMID:32766577)
RGD
PMID:15479853 PMID:24623090 PMID:32766577
NCBI chr12:1,915,902...1,924,529
Ensembl chr12:1,915,919...1,924,539
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Clec5a
C-type lectin domain containing 5A
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859
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Cr2
complement C3d receptor 2
involved_in
ISO
(PMID:3036369)
RGD
PMID:3036369
NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
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Ctsb
cathepsin B
involved_in
IEA ISO
GO_REF:0000107 (PMID:15831716)
Ensembl RGD
PMID:15831716
GO_REF:0000107
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Ctsl
cathepsin L
involved_in
ISO
(PMID:16339146), (PMID:18562523), (PMID:26953343)
RGD
PMID:16339146 PMID:18562523 PMID:26953343
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Dag1
dystroglycan 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325
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Dpp4
dipeptidylpeptidase 4
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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Dppa1
developmental pluripotency associated 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:30,998,049...31,017,756
Ensembl chr10:30,998,049...31,017,756 Ensembl chr12:30,998,049...31,017,756
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Eps15
epidermal growth factor receptor pathway substrate 15
involved_in
ISO
(PMID:20202662)
RGD
PMID:20202662
NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
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Gas6
growth arrest specific 6
involved_in
ISS ISO
GO_REF:0000024 (PMID:21501828)
UniProt RGD
PMID:21501828
GO_REF:0000024
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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Gpr15
G protein-coupled receptor 15
involved_in
ISO
(PMID:15650194)
RGD
PMID:15650194
NCBI chr11:41,898,300...41,899,646
Ensembl chr11:41,898,356...41,900,441
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Grk2
G protein-coupled receptor kinase 2
involved_in
ISO IEA
(PMID:23029581) GO_REF:0000107
RGD Ensembl
PMID:23029581
GO_REF:0000107
NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
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Havcr1
hepatitis A virus cellular receptor 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Havcr1l1
hepatitis A virus cellular receptor 1 like 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:30,919,860...30,941,388
Ensembl chr10:30,923,809...30,941,108
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Havcr1l2
hepatitis A virus cellular receptor 1 like 2
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:30,963,058...30,983,169
Ensembl chr10:30,968,739...30,981,979
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Hyal2
hyaluronidase 2
involved_in
IDA IEA
facilitates GO_REF:0000108
GOC RGD
PMID:12584308
GO_REF:0000108, RGD:633153
NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850
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Ilf3
interleukin enhancer binding factor 3
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350
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Insr
insulin receptor
involved_in
ISO
(PMID:17001305)
RGD
PMID:17001305
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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Itgav
integrin subunit alpha V
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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Itgb3
integrin subunit beta 3
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Myh10
myosin heavy chain 10
involved_in
ISO IEA
(PMID:25428876) GO_REF:0000108
RGD GOC
PMID:25428876
GO_REF:0000108
NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165
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Myh9
myosin, heavy chain 9
involved_in
ISO
(PMID:20944748)
RGD
PMID:20944748
NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
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Nectin1
nectin cell adhesion molecule 1
involved_in
IMP ISO
(PMID:22146396), (PMID:25231300), (PMID:28542478)
RGD
PMID:22146396 PMID:25231300 PMID:28542478 PMID:12584355
RGD:1599797
NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787
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Nectin3
nectin cell adhesion molecule 3
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519
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Nectin4
nectin cell adhesion molecule 4
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709
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Npc1
NPC intracellular cholesterol transporter 1
involved_in
ISO
(PMID:21866101), (PMID:21866103)
RGD
PMID:21866101 PMID:21866103
NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
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Phb1
prohibitin 1
involved_in
ISO
(PMID:29324904)
RGD
PMID:29324904
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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Plscr1
phospholipid scramblase 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
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Pvr
PVR cell adhesion molecule
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
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Serpinb3
serpin family B member 3
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682
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Siglec1
sialic acid binding Ig like lectin 1
involved_in
ISO
(PMID:12857889)
RGD
PMID:12857889
NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850
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Siva1
SIVA1, apoptosis-inducing factor
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690
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Slamf1
signaling lymphocytic activation molecule family member 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497
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Slc20a2
solute carrier family 20 member 2
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr16:69,460,850...69,551,418
Ensembl chr16:69,460,462...69,521,711
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Slc3a2
solute carrier family 3 member 2
involved_in
IEA ISO
GO_REF:0000107 (PMID:30341327)
Ensembl RGD
PMID:30341327
GO_REF:0000107
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc7a1
solute carrier family 7 member 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849
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Smpd1
sphingomyelin phosphodiesterase 1
involved_in acts_upstream_of acts_upstream_of_positive_effect
ISO
(PMID:22573858) (PMID:33163980)
RGD
PMID:22573858 PMID:33163980
NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
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Timd2
T-cell immunoglobulin and mucin domain containing 2
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623
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Tyro3
TYRO3 protein tyrosine kinase
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142
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Uvrag
UV radiation resistance associated
acts_upstream_of_or_within
ISO
(PMID:24550300)
RGD
PMID:24550300
NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
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Vamp8
vesicle-associated membrane protein 8
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:24550300) GO_REF:0000107
RGD Ensembl
PMID:24550300
GO_REF:0000107
NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
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Vps16
VPS16 core subunit of CORVET and HOPS complexes
acts_upstream_of_or_within
ISO
(PMID:24550300)
RGD
PMID:24550300
NCBI chr 3:117,622,534...117,644,041
Ensembl chr 3:117,622,542...117,646,441
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Vps18
VPS18 core subunit of CORVET and HOPS complexes
acts_upstream_of_or_within
ISO
(PMID:24550300)
RGD
PMID:24550300
NCBI chr 3:106,279,444...106,290,298
Ensembl chr 3:106,279,425...106,291,964
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Xpr1
xenotropic and polytropic retrovirus receptor 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr13:67,441,205...67,585,950
Ensembl chr13:67,446,380...67,585,946
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Zfp639
zinc finger protein 639
involved_in
ISS IEA
GO_REF:0000024 GO_REF:0000107
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr 2:115,292,431...115,305,798
Ensembl chr 2:115,292,516...115,303,628
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Siglec1
sialic acid binding Ig like lectin 1
involved_in
ISO IBA
(PMID:12857889) GO_REF:0000033
RGD GO_Central
PMID:12857889
GO_REF:0000033
NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850
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Jpt2
Jupiter microtubule associated homolog 2
involved_in
ISO
(PMID:15094197)
RGD
PMID:15094197
NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170
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Tpcn1
two pore segment channel 1
involved_in
ISO IEA
(PMID:25722412) GO_REF:0000107
RGD Ensembl
PMID:25722412
GO_REF:0000107
NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626
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Tpcn2
two pore segment channel 2
involved_in
ISO IBA
(PMID:25722412) GO_REF:0000033
RGD GO_Central
PMID:25722412
GO_REF:0000033
NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236
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Ch25h
cholesterol 25-hydroxylase
involved_in
ISO ISS
(PMID:32944968), (PMID:33239446) GO_REF:0000024
RGD UniProt
PMID:32944968 PMID:33239446
GO_REF:0000024
NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
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Bsg
basigin
involved_in
ISO
(PMID:11353871), (PMID:15688292), (PMID:29739904)
RGD
PMID:11353871 PMID:15688292 PMID:29739904
NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
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Cd4
Cd4 molecule
involved_in
ISO IEA
(PMID:24942581) GO_REF:0000107
RGD Ensembl
PMID:24942581
GO_REF:0000107
NCBI chr 4:157,668,878...157,695,366
Ensembl chr 4:157,668,878...157,695,191
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Cd74
CD74 molecule
involved_in
ISO IEA
(PMID:24942581) GO_REF:0000107
RGD Ensembl
PMID:24942581
GO_REF:0000107
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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Furin
furin (paired basic amino acid cleaving enzyme)
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
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Lgals1
galectin 1
involved_in
ISO IEA
(PMID:21670307) GO_REF:0000107
RGD Ensembl
PMID:21670307
GO_REF:0000107
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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Lgals9
galectin 9
involved_in
ISO
(PMID:21670307)
RGD
PMID:21670307
NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
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Nectin1
nectin cell adhesion molecule 1
involved_in
ISO
(PMID:11277703)
RGD
PMID:11277703
NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787
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P4hb
prolyl 4-hydroxylase subunit beta
involved_in
ISO
(PMID:21670307)
RGD
PMID:21670307
NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
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RT1-Db1
RT1 class II, locus Db1
involved_in
ISO
(PMID:24942581)
RGD
PMID:24942581
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
G
Smpd1
sphingomyelin phosphodiesterase 1
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
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Tmprss2
transmembrane serine protease 2
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
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Tmprss4
transmembrane serine protease 4
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
G
Trim11
tripartite motif-containing 11
involved_in
ISO
(PMID:18248090)
RGD
PMID:18248090
NCBI chr10:43,758,299...43,771,138
Ensembl chr10:43,758,354...43,771,138
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Trim38
tripartite motif containing 38
involved_in
ISO
(PMID:18248090)
RGD
PMID:18248090
NCBI chr17:41,351,857...41,365,021
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Cav1
caveolin 1
involved_in
ISO IEA
UniProtKB:P51636 (PMID:21047970) GO_REF:0000107
RGD Ensembl
PMID:21047970
GO_REF:0000107
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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Cav2
caveolin 2
involved_in
IEA ISO
GO_REF:0000107 UniProtKB:O60840 (PMID:21047970)
Ensembl RGD
PMID:21047970
GO_REF:0000107
NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
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Ctsl
cathepsin L
involved_in
ISO
(PMID:16081529), (PMID:32855215)
RGD
PMID:16081529 PMID:32855215
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Eps15
epidermal growth factor receptor pathway substrate 15
involved_in
ISO
(PMID:21047970)
RGD
PMID:21047970
NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
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KIAA0319l
KIAA0319 like
acts_upstream_of_or_within
ISO
MGI:5907241|MGI:5907242 (PMID:26814968)
RGD
PMID:26814968
NCBI chr 5:139,047,847...139,140,709
Ensembl chr 5:139,046,143...139,140,715
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Rnasek
ribonuclease K
involved_in
ISO
(PMID:26212330)
RGD
PMID:26212330
NCBI chr10:54,954,904...54,956,622
Ensembl chr10:54,951,991...54,956,601
G
Tpcn2
two pore segment channel 2
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236
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Hs3st5
heparan sulfate-glucosamine 3-sulfotransferase 5
involved_in
ISO
(PMID:12138164)
RGD
PMID:12138164
NCBI chr20:40,106,876...40,417,661
Ensembl chr20:40,106,876...40,417,653
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Nectin2
nectin cell adhesion molecule 2
involved_in
ISO
(PMID:11602758)
RGD
PMID:11602758
NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
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Rfpl4a
ret finger protein-like 4A
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:68,728,964...68,735,423
Ensembl chr 1:68,728,964...68,735,423
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Trim21
tripartite motif-containing 21
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
G
Trim25
tripartite motif-containing 25
involved_in
ISO
(PMID:18248090)
RGD
PMID:18248090
NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257
G
Trim30c
tripartite motif-containing 30C
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:158,766,401...158,787,915
Ensembl chr 1:158,765,969...158,787,183
G
Trim30d
tripartite motif-containing 30D
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:158,795,288...158,813,913
Ensembl chr 1:158,720,410...158,814,012
G
Trim34
tripartite motif-containing 34
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:158,707,172...158,720,214
Ensembl chr 1:158,707,172...158,718,674
G
Trim5
tripartite motif-containing 5
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:158,720,407...158,737,393
Ensembl chr 1:158,720,410...158,814,012
G
Trim58
tripartite motif-containing 58
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:43,022,933...43,038,984
Ensembl chr10:43,022,996...43,034,476
G
Trim6
tripartite motif containing 6
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:158,683,746...158,696,936
Ensembl chr 1:158,683,746...158,696,914
G
Trim62
tripartite motif-containing 62
involved_in
ISO
(PMID:18248090)
RGD
PMID:18248090
NCBI chr 5:141,230,830...141,260,629
Ensembl chr 5:141,231,523...141,259,915
G
Trim68
tripartite motif containing 68
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:157,114,044...157,127,494
Ensembl chr 1:157,114,044...157,127,477
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all