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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of steroid metabolic process
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Accession:GO:0045939 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
Synonyms:exact_synonym: down regulation of steroid metabolic process;   downregulation of steroid metabolic process;   negative regulation of steroid metabolism
 narrow_synonym: inhibition of steroid metabolic process


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negative regulation of steroid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of IMP PMID:24201375 ARUK-UCL PMID:24201375 RGD:14697729 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19584291)		 Ensembl
RGD		 PMID:19584291 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IEA
IMP		 (PMID:19342457)
GO_REF:0000107		 RGD
Ensembl		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in ISO
IEA		 (PMID:16959810)
GO_REF:0000107		 RGD
Ensembl		 PMID:16959810 GO_REF:0000107 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within		 ISO (PMID:12815072)
MGI:1928271 (PMID:23747249)		 RGD PMID:12815072 PMID:23747249 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Malrd1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within ISO MGI:1096383|MGI:2154956 (PMID:23747249) RGD PMID:23747249 NCBI chr17:78,418,819...79,131,015
Ensembl chr17:78,418,819...79,131,016 		JBrowse link
G Mir33 microRNA 33 involved_in ISO (PMID:23536474) RGD PMID:23536474 NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923 		JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:16488887) RGD PMID:16488887 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in ISO (PMID:16549446) RGD PMID:16549446 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor involved_in ISO (PMID:15947108) RGD PMID:15947108 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO (PMID:15243130) RGD PMID:15243130 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IDA
IEA
ISO		 GO_REF:0000107
(PMID:1917954)		 Ensembl
RGD		 PMID:1917954 PMID:9225228 GO_REF:0000107, RGD:10059686 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G C12h7orf50 similar to human chromosome 7 open reading frame 50 involved_in ISO (PMID:38503280) RGD PMID:38503280 NCBI chr12:15,185,728...15,289,042
Ensembl chr12:15,185,707...15,289,069 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) RGD PMID:24217618 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (PMID:17202134) RGD PMID:17202134 NCBI chr17:61,331,385...61,334,987
Ensembl chr17:61,331,669...61,334,285 		JBrowse link
G Insig1 insulin induced gene 1 involved_in ISO (PMID:26311497) RGD PMID:26311497 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Mir185 microRNA 185 acts_upstream_of ISO RNAcentral:URS00002367FA_9606|RNAcentral:URS00004176D4_9606 (PMID:23951060), (PMID:24296663) RGD PMID:23951060 PMID:24296663 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795 		JBrowse link
G Mir342 microRNA 342 acts_upstream_of ISO (PMID:23951060) RGD PMID:23951060 NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367 		JBrowse link
G Mir98 microRNA 98 involved_in ISO (PMID:30195495) RGD PMID:30195495 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
negative regulation of cholesterol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ch25h cholesterol 25-hydroxylase involved_in ISO (PMID:29033131) RGD PMID:29033131 NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195 		JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO
IEA		 (PMID:19584291)
GO_REF:0000107		 RGD
Ensembl		 PMID:19584291 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IEA
IMP		 (PMID:19342457)
GO_REF:0000107		 RGD
Ensembl		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2451290 (PMID:17234593)		 Ensembl
RGD		 PMID:17234593 GO_REF:0000107 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
negative regulation of steroid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Hrh1 histamine receptor H 1 IMP RGD PMID:15917347 RGD:2316921 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Insig1 insulin induced gene 1 acts_upstream_of_or_within ISO MGI:1920249 (PMID:16100574) RGD PMID:16100574 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1916289 (PMID:16100574)		 Ensembl
RGD		 PMID:16100574 GO_REF:0000107 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 acts_upstream_of
involved_in		 ISO
ISS
IEA		 (PMID:9384387)
GO_REF:0000024
GO_REF:0000107		 RGD
HGNC-UCL
Ensembl		 PMID:9384387 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011 		JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO (PMID:15317892), (PMID:18182450) RGD PMID:15317892 PMID:18182450 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde8b phosphodiesterase 8B acts_upstream_of_or_within ISO MGI:5526098 (PMID:21187369) RGD PMID:21187369 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkkl1 dickkopf like acrosomal protein 1 involved_in ISO (PMID:18818293) RGD PMID:18818293 NCBI chr 1:95,694,010...95,699,259
Ensembl chr 1:95,694,010...95,699,259 		JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO
IEA		 (PMID:12949260)
GO_REF:0000107		 RGD
Ensembl		 PMID:12949260 GO_REF:0000107 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:19502595) RGD PMID:19502595 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:18485278), (PMID:19502595) RGD PMID:18485278 PMID:19502595 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20075
    cellular process 19154
      metabolic process 11953
        negative regulation of metabolic process 3176
          negative regulation of lipid metabolic process 125
            negative regulation of steroid metabolic process 32
              negative regulation of aldosterone metabolic process + 4
              negative regulation of bile acid metabolic process + 4
              negative regulation of cholesterol metabolic process + 10
              negative regulation of ecdysteroid metabolic process + 0
              negative regulation of glucocorticoid metabolic process + 5
              negative regulation of steroid biosynthetic process + 30
Path 2
Term Annotations click to browse term
  biological_process 20075
    biological regulation 13559
      regulation of biological process 13136
        regulation of cellular process 12773
          regulation of metabolic process 6747
            regulation of primary metabolic process 5650
              regulation of lipid metabolic process 388
                negative regulation of lipid metabolic process 125
                  negative regulation of steroid metabolic process 32
                    negative regulation of aldosterone metabolic process + 4
                    negative regulation of bile acid metabolic process + 4
                    negative regulation of cholesterol metabolic process + 10
                    negative regulation of ecdysteroid metabolic process + 0
                    negative regulation of glucocorticoid metabolic process + 5
                    negative regulation of steroid biosynthetic process + 30
paths to the root