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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of isotype switching
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Accession:GO:0045829 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: down regulation of isotype switching;   downregulation of isotype switching;   negative regulation of class switch recombination;   negative regulation of class switching;   negative regulation of isotype switch recombination
 narrow_synonym: inhibition of isotype switching


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negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:26000965) 		Ensembl
RGD		 PMID:26000965 GO_REF:0000107 NCBI chr 8:115,989,721...115,995,822
Ensembl chr 8:115,987,176...115,995,472 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:103034|MGI:2158438 (PMID:10490661) 		Ensembl
RGD		 PMID:10490661 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3696705 (PMID:16275384) 		Ensembl
RGD		 PMID:16275384 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3695433 (PMID:17137798) 		Ensembl
RGD		 PMID:17137798 GO_REF:0000107 NCBI chr18:30,516,931...30,567,199
Ensembl chr18:30,516,981...30,568,471 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    developmental process 7255
      negative regulation of developmental process 1116
        negative regulation of isotype switching 4
          negative regulation of isotype switching to IgA isotypes 0
          negative regulation of isotype switching to IgD isotypes 0
          negative regulation of isotype switching to IgE isotypes 3
          negative regulation of isotype switching to IgG isotypes 0
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        primary metabolic process 10162
          nucleobase-containing compound metabolic process 5642
            nucleic acid metabolic process 5071
              DNA metabolic process 986
                DNA recombination 352
                  somatic cell DNA recombination 82
                    somatic diversification of immune receptors via germline recombination within a single locus 82
                      somatic recombination of immunoglobulin gene segments 70
                        somatic recombination of immunoglobulin genes involved in immune response 59
                          isotype switching 59
                            regulation of isotype switching 41
                              negative regulation of isotype switching 4
                                negative regulation of isotype switching to IgA isotypes 0
                                negative regulation of isotype switching to IgD isotypes 0
                                negative regulation of isotype switching to IgE isotypes 3
                                negative regulation of isotype switching to IgG isotypes 0
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